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234 (0,126s) •

Project

Germline mutations of PML gene in patients with cancer (NR9092)

Mutational analysis of PML gene will be performed in patients with breast and colon cancer with suspect hereditary predisposition to cancer. Cyclin D1 and ZNF217 gene amplification analysis will be performed in breast cancer samples...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 2 645 tis. Kč
    • •
  • 2 244 tis. Kč
    • •
  • MZ
Project

Psychosocial aspects of hereditary forms of breast and ovarian cancer. The study of women with proved hereditary etiology. (NR8022)

Psychosocial effect of genetic counseling and testing of hereditary etiology of breast/ovarian cancer. The influence of testing on quality of life of high-risk women. Mapping of the level of preventive care of women with hereditary ...

FQ - Veřejné zdravotnictví, sociální lékařství

  • 2004 - 2006
    • •
  • 2 244 tis. Kč
    • •
  • 2 214 tis. Kč
    • •
  • MZ
Project

Hereditary cancer predisposition in breast or colorectal cancer patients not indicated for routine genetic testing (NU20-03-00283)

Patients with hereditary cancer syndromes represent a clinically important subgroup of oncology patients. Early identification of pathogenic germline mutations in tens of clinically relevant cancer predisposition genes influences tr...

Oncology

  • 2020 - 2023
    • •
  • 11 720 tis. Kč
    • •
  • 11 720 tis. Kč
    • •
  • MZ
Project

BIOINFORMATICS AND FUNCTIONAL ANALYSES OF SUSCEPTIBILITY VARIANTS SUPPORTING THE NGS-BASED TESTING OF HEREDITARY CANCERS IN THE CZECH REPUBLIC (II) (NU20-03-00285)

predisposition genes in high-risk individuals. Identification of causal mutation has critical laboratories unifying cancer predisposition analysis by CZECANCA (Czech cancer panel in these activities to comprehensively characterize ...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2020 - 2023
    • •
  • 11 831 tis. Kč
    • •
  • 11 831 tis. Kč
    • •
  • MZ
Project

Analysis of p53, CHK2, SNF5, and other candidate genes in BRCA1/2 negative cancer families with breast tumours and other malignancies (NC6513)

of fraction of families with a striking hereditary predisposition but with no geneticAnalysis of germline p53, CHK2 and SNF5 gene mutations, rearrangements and polymorphisms in families with hereditary breast cancer and ot...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 2 381 tis. Kč
    • •
  • 2 380 tis. Kč
    • •
  • MZ
Project

Characterization of genetic predisposition to ovarian cancer using genomic approaches in patients diagnosed with ovarian cancer before the age of 30 (NU20-03-00016)

Ovarian cancer is a disease with a high proportion of hereditary form. In the preceding project analyzing a gene panel in ovarian cancer patients and population with known/anticipated predisposition to ovarian cancer in patients dia...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2023
    • •
  • 10 063 tis. Kč
    • •
  • 10 063 tis. Kč
    • •
  • MZ
Project

Hereditary skin malignant melanoma in miniature pigs-characterization and experimental therapy (GA523/98/0229)

We found in preliminary studies a hereditary predisposition to malignant melanoma (MM) in miniature pigs. Using this model we will analyse genetic and some other factors responsible for this malignant process. It will be characteris...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 1998 - 2000
    • •
  • 4 323 tis. Kč
    • •
  • 3 912 tis. Kč
    • •
  • GA ČR
Project

Alcohol and regulation of lipoprotein metabolism (NR7847)

The effect of alcohol consumption on expression of genes involved in regulation of lipoprotein metabolism (apolipoprotein A-I, ABC A1 transporter, lipoprotein lipase) will be studied in C57BL/6 mice. The role of genetic predisposition to hyp...

ED - Fyziologie

  • 2004 - 2006
    • •
  • 1 623 tis. Kč
    • •
  • 1 455 tis. Kč
    • •
  • MZ
Project

Targeted NEXT-GEN sequencing as a tool for identification of the new breast cancer susceptibility genes in high-risk patients (NT14054)

Candidate genetic BC predisposition factors will be identified using the next-gen sequencing on SOLiD4 analyzer. Entire coding sequence of >250 selected genes isolated by exon trapping will be analyzed in 300 samples of high-risk (BRCA1/2-ne...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 202 tis. Kč
    • •
  • 7 202 tis. Kč
    • •
  • MZ
Project

Clinical classification of sequence variants in non-coding regulatory regions in breast cancer susceptibility genes (NV16-33444A)

Breast cancer is the most frequent malignancy in the female population and presents a serious health problem. Approximately 5–10% of all breast cancer cases are of hereditary origin characterized by early and repetitive onset. The identifica...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 4 843 tis. Kč
    • •
  • 4 843 tis. Kč
    • •
  • MZ
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