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8 490 (0,125s) •

Project

Immunogenetics in the Next Generation Sequencing era Deciphering the pathogenetic mechanisms in lymphoproliferative disorders (GJ19-23424Y)

Immunogenetic sequence analysis is a powerful tool in basic research aimed at identifying the mechanisms underlying lymphomagenesis and the emergence of high-throughput pathogenesis remains unknown. On these grounds, we wil...

Human genetics

  • 2019 - 2022
    • •
  • 5 860 tis. Kč
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  • 5 860 tis. Kč
    • •
  • GA ČR
Project

Technological innovation of high troughput molecular diagnostic of clinically and molecularly heterogeneous genetic disorder (7E09052)

. The recently introduced high-throughput whole genome sequencing (WGS) technologynow offersSince the sequencing of the human genome has been completed the demand for genetic analysis in the human health care syste...

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 171 tis. Kč
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  • 171 tis. Kč
    • •
  • MŠMT
Project

New genes for degradation of aromatic hydrocarbons in highly contaminated environment (GA17-23794S)

- and polyaromatic hydrocarbons environments. Complex approach will be applied involving high-throughput sequencing and analysis of metagenomic clones and microbial communities......

DK - Kontaminace a dekontaminace půdy včetně pesticidů

  • 2017 - 2021
    • •
  • 5 871 tis. Kč
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  • 5 826 tis. Kč
    • •
  • GA ČR
Project

Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study. (NV15-30015A)

advanced methodology for the high-throughput IG sequence analysis to produce, manage and delve into extensive immunogenetic sequence datasets in CLL. Furthermore stimulation operation in CLL, which is also support...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 15 351 tis. Kč
    • •
  • 15 028 tis. Kč
    • •
  • MZ
Project

Use of parallel sequencing methods for monitoring of oral microbiome dynamics in the course of periodontal disease development and therapy. (NV17-30753A)

The aim of the project is to evaluate the applicability of high throughput sequencing (HTS) as a tool for complex characterization of oral microbiome dynamics and thus for early diagnosis of risk and onset of periodontitis ...

EE - Mikrobiologie, virologie

  • 2017 - 2021
    • •
  • 9 319 tis. Kč
    • •
  • 9 319 tis. Kč
    • •
  • MZ
Project

High-throughput genomic profiling for personalised diagnostics and treatment of haematopoietic disorders in children (NV15-30626A)

Contemporary high-throughput genomic techniques including Next Generation Sequencing and Single Nucleotide Polymorphism analysis allow individual characterization of childhood patients suffering from selected haematopoietic...

FG - Pediatrie

  • 2015 - 2019
    • •
  • 19 097 tis. Kč
    • •
  • 19 097 tis. Kč
    • •
  • MZ
Project

Targeted NEXT-GEN sequencing as a tool for identification of the new breast cancer susceptibility genes in high-risk patients (NT14054)

-gen sequencing on SOLiD4 analyzer. Entire coding sequence of >250 selected genes isolated by exon trapping will be analyzed in 300 samples of high-risk (BRCA1/2-negative) BC patients and 300 controls. Following the mapping...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 202 tis. Kč
    • •
  • 7 202 tis. Kč
    • •
  • MZ
Project

Viromics of the European house mouse hybrid zone a model to understand how viruses cross host species barriers (GA22-32394S)

Many emerging diseases are caused by viruses crossing species barriers from their host of origin and high throughput sequencing (HTS) has led to unprecedented discoveries of virus diversity, even in well-studied models such...

Infectious Diseases

  • 2022 - 2024
    • •
  • 10 779 tis. Kč
    • •
  • 10 779 tis. Kč
    • •
  • GA ČR
Project

Integration preference of retroviruses (GA204/07/1030)

of microchromosomesand a high density of genes. Despite the significant methodological progress, there is still a need for reliable, unbiased and high throughput technique of integration integrate preferentially into GC-ri...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 4 218 tis. Kč
    • •
  • 4 218 tis. Kč
    • •
  • GA ČR
Project

Comparative genome analysis in banana (Musa spp.) using 454 sequencing (KJB500380901)

largely unknown. In this project, we will use ultra-high-throughput DNA sequencing technology (454 Sequencing, Roche). The current system, the genome sequencer FLX, generates about 100 million high

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 688 tis. Kč
    • •
  • 1 688 tis. Kč
    • •
  • AV ČR
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