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9 (0,103s) •

Project

Relation between the proficiency of hippocampal circuits recovery after transplantation and functional activity of adult rats (IZ3754)

FJ - Chirurgie včetně transplantologie

  • 1996 - 1998
    • •
  • 1 003 tis. Kč
    • •
  • 961 tis. Kč
    • •
  • MZ
Project

Radiosurgical lesion of the rat hippocampus using the Leksell gamma knife relation between radiation dose and functional and structural damage. (NF5161)

Radiosurgical lesion of the rat hippocampus using the Leksell gamma knife. Test of memory impairment after radiosurgery in water maze. MR imaging and MR spectroscopy of the rat brain before and after radiosurgery. Test of changes in non-synaptic tran...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 2 971 tis. Kč
    • •
  • 2 777 tis. Kč
    • •
  • MZ
Project

Narcolepsy – clinical picture, pathophysiology, ageing, comorbidities and physical activity regimen (NT13238)

Narcolepsy is a neurological disease characterized especially by excessive daytime sleepiness. It presents with two forms – narcolepsy with cataplexy (N+C) and without cataplexy (N-C). Pathophysiology of N+C is known to some degree but the same is no...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
    • •
  • 7 079 tis. Kč
    • •
  • 6 704 tis. Kč
    • •
  • MZ
Project

Role of frontotemporal crosstalk in cognitive coordination and flexibility deficits in schizophrenia A translational study (NV17-30833A)

Disturbances of cognitive functions have been recognized as hallmarks of schizophrenia and predictors of therapeutic outcome. They significantly limit patient´s functioning, yet there are no specific treatments for cognitive deficits in this disease....

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2020
    • •
  • 12 693 tis. Kč
    • •
  • 12 693 tis. Kč
    • •
  • MZ
Project

The mechanisms of respiratory and cardiac dysfunction responsible for the increased risk of sudden unexpected death in epilepsy. (NU21-04-00601)

Sudden unexpected death in epilepsy (SUDEP) is a major challenge in epilepsy research and practice. These deaths follow generalized tonic clonic seizures. They are caused by respiratory failure, preceded by transient cardiac and respiratory dysfuncti...

Clinical neurology

  • 2021 - 2024
    • •
  • 10 808 tis. Kč
    • •
  • 10 808 tis. Kč
    • •
  • MZ
Project

Obesity as a risk factor for adverse brain, cognitive and clinical outcomes in schizophrenia – prospective study. (NU20-04-00393)

Obesity frequently co-occurs with Schizophrenia (Sch) and typically presents with similar neurostructural and cognitive impairments as Sch. We propose to test whether obesity is a risk factor for brain/cognitive/clinical deterioration over time in Sc...

Psychiatry

  • 2020 - 2023
    • •
  • 11 774 tis. Kč
    • •
  • 11 774 tis. Kč
    • •
  • MZ
Project

Diabetes and pre-diabetes as biological risk factors for brain atrophy and memory impairment in schizophrenia (NV16-32791A)

The study of metabolic comorbidities in psychiatric disorders may lead to new insights into common mechanisms of disease. It could help identify modifiable risk factors for brain alterations. Diabetes (DM) or prediabetes (pre-DM) frequently co-occur ...

FL - Psychiatrie, sexuologie

  • 2016 - 2019
    • •
  • 8 984 tis. Kč
    • •
  • 8 984 tis. Kč
    • •
  • MZ
Project

Hippocampal involvement in neocortical epilepsy networks Implications for surgical planning (NU21J-08-00081)

Epilepsy is a neurological disorder characterized by recurrent seizures. A subpopulation of patients with pharmacoresistant epilepsy can benefit from epilepsy surgery. The success of the surgery is determined by the precise localization and complete ...

Clinical neurology

  • 2021 - 2024
    • •
  • 6 706 tis. Kč
    • •
  • 6 706 tis. Kč
    • •
  • MZ
Project

Multimodal non-invasive biomarkers for early diagnosis of limbic-predominant neurodegenerative diseases (NW25-04-00337)

The essence of the proposed project is to improve the diagnosis of neurodegenerative diseases that cause cognitive impairment, which are expected to increase significantly due to the ageing population, have a major impact on society as a whole, are a...

Clinical neurology

  • 2025 - 2028
    • •
  • 17 228 tis. Kč
    • •
  • 17 228 tis. Kč
    • •
  • MZ
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