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114 (0,129s) •

Project

Plant H3-H4 histone chaperone networks (8J20FR022)

Our aim is to gain insight into the mechanisms controlling histone dynamics through a dedicated histone chaperone network. Histone chaperones have been shown to specifically handle certain histone variants with dis...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2022
    • •
  • 156 tis. Kč
    • •
  • 156 tis. Kč
    • •
  • MŠMT
Project

Comprehensive characterization of histone epigenetic marks (GA22-28190S)

Histone post-translational modifications (PTMs) are essential epigenetic to the disease formation, the development of methods for deeper histone characterization applied as the first choice for PTMs analysis. The determination of

Analytical chemistry

  • 2022 - 2024
    • •
  • 6 324 tis. Kč
    • •
  • 6 082 tis. Kč
    • •
  • GA ČR
Project

Modification of histones in chromatin regions with increased and reduced expression (1K04112)

The variety of histone modifications (histone code) is believed to mark expression or silencing of genes. Clustering of active or silent genes in regions the histone-code hypothesis. The most important in this context are H...

EB - Genetika a molekulární biologie

  • 2004 - 2005
    • •
  • 448 tis. Kč
    • •
  • 238 tis. Kč
    • •
  • MŠMT
Project

Postranslational modifications of histones after cell treatment by inhibitors of histone deacetylases and during induction of cell differentiation (GA204/06/0978)

Postranslational modifications of histone tails represent an important. Selected epigenetic histone modifications together with variants of heterochromatin of histone deacetylases (HDACi) that have also an ability to induce...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 878 tis. Kč
    • •
  • 1 878 tis. Kč
    • •
  • GA ČR
Project

Mechanisms involved in epigenetic control of expression and function of androgen receptor (AR) in prostate cancer Potential therapeutic implications of AR coactivators blockade. (NS10262)

1/ Regulation of mechanism by which corepressors compete with coactivators for binding to androgen receptor. 2/ Elucidate an effect of the inhibitor histone deacetylation on changes of covalent histone modifications. 3/ Determine wh...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 340 tis. Kč
    • •
  • 2 222 tis. Kč
    • •
  • MZ
Project

The efect of methylation and acetylation on chromatin structure (GP202/03/D033)

Biochemical modifications of DNA and histones (especially methylation of histones and DNA exist on parallel pathway, however the mutual relationship between the acetylation status of histones on metaphase chromosomes of hum...

EB - Genetika a molekulární biologie

  • 2003 - 2006
    • •
  • 736 tis. Kč
    • •
  • 736 tis. Kč
    • •
  • GA ČR
Project

Targets and consequences of activation-induced cytidine deaminase-mediated mutagenesis in tumours (GN24-11338I)

to the development of tumours. Histone genes are frequent targets of AID activity, both in human lymphomas and in murine cell models. The role of histone genes in tumour development has, and consequences of mutagenesis of histo...

Cell biology

  • 2024 - 2027
    • •
  • 6 323 tis. Kč
    • •
  • 6 323 tis. Kč
    • •
  • GA ČR
Project

The effect of histone deacetylase inhibitors on TEL/AML1 - positive leukaemic cells (NR8316)

Using histone deacetylase inhibitors, we will study chromatin remodelling leading to apoptosis and differentiation of TEL/AML1-positive leukaemic cells. We will analyse in vitro effect of this therapy on the changes of cell cycle and the gen...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 3 877 tis. Kč
    • •
  • 3 834 tis. Kč
    • •
  • MZ
Project

Molecular basis for site-specific read-out of histone H3K4me2 by the Set3 PHD finger (GA15-17670S)

The Set3 histone deacetylase complex can combine with non-coding RNA contain H3 histone dimethylated at lysine 4 (H3K4me2) instead of trimethylated to be responsible for recognition of methylated histones. To reveal this ne...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 8 040 tis. Kč
    • •
  • 8 040 tis. Kč
    • •
  • GA ČR
Project

Nuclear Structure and Histone Acetylation in Plant Cells (IAA5004901)

Recent data indicate that H4 and H3 histones are underacetylated in both constitutive and faculative heterochromatin, while their hyperacetylation marks potentially andindirect immunocytochemistry we will analyse histone acetylation...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 4 366 tis. Kč
    • •
  • 2 079 tis. Kč
    • •
  • AV ČR
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