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1 649 (0,146s) •

Project

Comprehensive characterization of histone epigenetic marks (GA22-28190S)

Histone post-translational modifications (PTMs) are essential epigenetic regulators of gene expression. As the imbalance in the modification status often leads to the disease formation, the development of methods for deeper...

Analytical chemistry

  • 2022 - 2024
    • •
  • 6 324 tis. Kč
    • •
  • 6 082 tis. Kč
    • •
  • GA ČR
Project

Modification of histones in chromatin regions with increased and reduced expression (1K04112)

The variety of histone modifications (histone code) is believed to mark expression or silencing of genes. Clustering of active or silent genes in regions the histone-code hypothesis. The most important in this cont...

EB - Genetika a molekulární biologie

  • 2004 - 2005
    • •
  • 448 tis. Kč
    • •
  • 238 tis. Kč
    • •
  • MŠMT
Project

The efect of methylation and acetylation on chromatin structure (GP202/03/D033)

Biochemical modifications of DNA and histones (especially methylation structure with regards to its transcriptional activity/inactivity. Modifications of histones and DNA exist on parallel pathway, however the mutu...

EB - Genetika a molekulární biologie

  • 2003 - 2006
    • •
  • 736 tis. Kč
    • •
  • 736 tis. Kč
    • •
  • GA ČR
Project

Postranslational modifications of histones after cell treatment by inhibitors of histone deacetylases and during induction of cell differentiation (GA204/06/0978)

Postranslational modifications of histone tails represent an important. Selected epigenetic histone modifications together with variants of heterochromatin of histone deacetylases (HDACi) that have also an...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 878 tis. Kč
    • •
  • 1 878 tis. Kč
    • •
  • GA ČR
Project

Mechanisms involved in epigenetic control of expression and function of androgen receptor (AR) in prostate cancer Potential therapeutic implications of AR coactivators blockade. (NS10262)

for binding to androgen receptor. 2/ Elucidate an effect of the inhibitor histone deacetylation on changes of covalent histone modifications. 3/ Determine whether histone modifications changes (acetylatio...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 340 tis. Kč
    • •
  • 2 222 tis. Kč
    • •
  • MZ
Project

Redox signalling to chromatin during stress responses in plants (GA22-17092S)

histone modifications are altered by histone-modifying enzymes in response to external transcriptional co-activator, is involved in histone acetylation and regulates numerous stress the genome-wide distribution of...

Plant sciences, botany

  • 2022 - 2024
    • •
  • 4 911 tis. Kč
    • •
  • 4 911 tis. Kč
    • •
  • GA ČR
Project

Influence of conformation motifs and epigenetic modifications to DNA binding properties of p53 family proteins (GA15-21855S)

An altered pattern of epigenetic modifications is central to many common human diseases, including cancer. DNA methylation, histone deacetylation, and methylation of histones are often associated with a repressed chromatin ...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 6 795 tis. Kč
    • •
  • 6 795 tis. Kč
    • •
  • GA ČR
Project

Nuclear Structure and Histone Acetylation in Plant Cells (IAA5004901)

Recent data indicate that H4 and H3 histones are underacetylated in both andindirect immunocytochemistry we will analyse histone acetylation patterns development. Histone acetylation status will be studied and corrrelated w...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 4 366 tis. Kč
    • •
  • 2 079 tis. Kč
    • •
  • AV ČR
Project

*Development of kit for testing molecular effects of anti-tumor drugs on chromatin structure (FR-TI2/509)

using HDACi (histone deacetylase inhibitors) in human leukemia....

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 20 016 tis. Kč
    • •
  • 14 812 tis. Kč
    • •
  • MPO
Project

Chromatin environment induced by genotoxic agents (GJ19-11880Y)

DNA damage induces chromatin reorganisation which is necessary to bring to the close proximity DNA damage sites and DNA repair machineries for efficient DNA repair. What is the molecular flux of nucleosomes, individual histone variants or ex...

Plant sciences, botany

  • 2019 - 2022
    • •
  • 6 878 tis. Kč
    • •
  • 6 878 tis. Kč
    • •
  • GA ČR
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