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The role of Hsp90 (Heat shock protein 90) in selected rheumatic diseases (NV16-33542A)
-fibrotic properties of Hsp90 in systemic sclerosis (SSc) and an efficient prevention of experimental dermal fibrosis by Hsp90 inhibition. In idiopathic inflammatory myopathies (IIM), Hsp90 expression was shown to be increa...
FE - Ostatní obory vnitřního lékařství
- 2016 - 2020 •
- 6 726 tis. Kč •
- 6 726 tis. Kč •
- MZ
Řešení projektu: 1. 4. 2016 - 31. 12. 2020
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Modulation of structural and functional properties of the HSP90 chaperone machinery by reversible acetylation (GA21-31806S)
Heat shock protein 90 (HSP90) is a molecular chaperone regulating cellular) is a principal deacetylase and a client protein of HSP90, but structural basis of HSP90 (de, and cell-based assays to elucidate structural and func...
Biochemistry and molecular biology
- 2021 - 2023 •
- 9 135 tis. Kč •
- 9 135 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2021 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Comparison of a Recombinant hsp90 Protein Vaccine and DNA Vaccine Protectivity in Mouse Vaginal and Systemic Candidiasis Model (NI7538)
Candida albicans hsp90 protein is considered as an immunodominant potentially protective antigen suitable to induce specific T cells and specific antibodies protective immunisation with hsp90 was not yet described unambiguously. Con...
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2003 - 2005 •
- 2 141 tis. Kč •
- 2 101 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2003 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Ministerstvo zdravotnictví
Microtubule-binding function of plant HSP90/82 protein (ME10111)
The goal of the project is to define the role of HSP90/82 associated with its microtubule- and membrane-binding functions in plant cells. Further, using unique biochemical methods, new proteins binding both microtubules and membrane will be ...
EB - Genetika a molekulární biologie
- 2010 - 2012 •
- 1 650 tis. Kč •
- 1 650 tis. Kč •
- MŠMT
Řešení projektu: 1. 5. 2010 - 31. 12. 2012
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Elucidating the role of ubiquitin-chaperone degradation machinery in cancer and modulating its biochemical functions using targeted chaperone inhibitors (NS9812)
The study will be accompanied by the analysis of Hsp90 and its isoforms alpha, colon and ovarian cancers and determination of the role of Hsp90 in stabilization of targetproteins. This analysis could predict the potential therapy re...
FD - Onkologie a hematologie
- 2008 - 2011 •
- 12 433 tis. Kč •
- 12 433 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Structural and functional analysis of Hsp70/Hsp90 chaperone complexes. (GA16-20860S)
Project is focused on the analysis of interactions between chaperones Hsp90 and Hsp70 and their co-chaperones. Combination of structural mass spectrometry with functional assays will be used to describe the interactions sites as well as part...
CE - Biochemie
- 2016 - 2020 •
- 7 015 tis. Kč •
- 6 571 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2016 - 22. 7. 2020
Uznané náklady
Podpora ze státního rozpočtu (94%)
Poskytovatel: Grantová agentura České republiky
Genetic and cell biology approaches to study regulation of YODA (MAP3K4) signaling by HSP90 proteins in Arabidopsis (GA17-24500S)
MAPK signaling pathway. Heat Shock Protein 90 (HSP90) is a highly abundant transduction pathways. Based on our preliminary results two HSP90 members were found is that HSP90 proteins through their interaction with YODA reg...
EB - Genetika a molekulární biologie
- 2017 - 2021 •
- 5 961 tis. Kč •
- 5 892 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Grantová agentura České republiky
Regulation of IFN-γ signaling pathway with HSP90 inhibitors (GA22-02940S)
on preliminary data, we propose that the HSP90 chaperone system modulates PD-L1 activity. We similarly to PD-L1. We will focus on identifying how HSP90 inhibitors (HSP90i) modify PD......
Biochemistry and molecular biology
- 2022 - 2024 •
- 9 081 tis. Kč •
- 8 862 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Grantová agentura České republiky
The analysis of chaperone system and identification of new biomarkers associated with gynecological malignancies (NT13794)
Chaperones play key roles in malignant transformation due to their ability to fold and stabilize mutant and oncogenic proteins. Hyper-activation of Hsp90 in gynecological malignancies is responsible mainly for stabilizing steroid hormone rec...
FD - Onkologie a hematologie
- 2012 - 2015 •
- 9 463 tis. Kč •
- 9 463 tis. Kč •
- MZ
Řešení projektu: 1. 4. 2012 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
The role of the chaperone system in malignant transformation and response to anti-cancer therapy (GAP301/11/1678)
. These abnormalities underpin the ability of Hsp90 inhibitors to effectively target cancer cells suppressor protein is regulated by the Hsp70/Hsp90 system in combination with co......
FD - Onkologie a hematologie
- 2011 - 2015 •
- 9 187 tis. Kč •
- 9 187 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2011 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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