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4 467 (0,097s) •

Project

Evaluation of ion channels and receptors in human neural progenitors derived from induced pluripotent stem cells during motoneuronal differentiation (GA17-21146S)

of ion channels and receptors in SCs is not fully understood. Our preliminary data indicated that differentiation of human induced pluripotent SCs (hiPSCs) toward mature neural cells, affects expression of ion channel and ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2018
    • •
  • 2 755 tis. Kč
    • •
  • 2 608 tis. Kč
    • •
  • GA ČR
Project

Understanding different aspects of structure and function of cation translocation systems. (LTC17069)

3D structural models of all human Orai family members; most probable multimeric state of the humanOrai channel; amino-acids regulating gating; quantification of Ca2+ binding to the unique, extracellular accumulating region CAR; dive...

BO - Biofyzika

  • 2017 - 2019
    • •
  • 2 083 tis. Kč
    • •
  • 2 083 tis. Kč
    • •
  • MŠMT
Project

Analysis and Enhancement of Speech and Image Signals form Noise for Cross-Modal Analysis of Verbal and Non-verbal Communication (OC08057)

Human speech, gestures, face-playing, head rotations and so on are not the subjects of emotion expression, which can be studied separately. If we understand how humans obtain information in communication from several channels

JA - Elektronika a optoelektronika, elektrotechnika

  • 2008 - 2010
    • •
  • 1 430 tis. Kč
    • •
  • 1 430 tis. Kč
    • •
  • MŠMT
Project

Signaling pathways affecting human TRPC5 receptor function Prediction of their association with rheumatoid arthritis pain (GA22-13750S)

) has been shown to amplify joint inflammation and hyperalgesia in human and murine aims to (i) screen for fundamental cellular mechanisms regulating human TRPC5 channel, (ii) genotype single nucleotide polymorphisms along ...

Neurosciences (including psychophysiology)

  • 2022 - 2024
    • •
  • 11 644 tis. Kč
    • •
  • 11 644 tis. Kč
    • •
  • GA ČR
Project

Modeling activation of human calcium release-activated channels. (GJ19-20728Y)

of the calcium stores upon depletion. CRAC is the combination of one channel located. In myocytes, non functional CRAC channels are known to be responsible for muscular of CRAC channels. We propose here to investigate the ...

Physical chemistry

  • 2019 - 2021
    • •
  • 3 479 tis. Kč
    • •
  • 3 479 tis. Kč
    • •
  • GA ČR
Project

Novel pharmacological strategies to target the sensor domain of temperature-activated TRPV channels (GA24-10147S)

Temperature sensitive TRPV channels play key roles in a wide range of physiological processes and are associated with many serious human diseases. The great promise of developing new drugs targeting these channels is severe...

Biophysics

  • 2024 - 2026
    • •
  • 7 889 tis. Kč
    • •
  • 7 750 tis. Kč
    • •
  • GA ČR
Project

Research of the effect of the non-stationary flow on the transport of fibers in successively bifurcating mini-channels (GA18-25618S)

Knowing the mechanics of fiber transport in mini-channels is essential in many of fiber transport under conditions existing in human lungs. While most of the previous studies focused on spherical particles, the human exposu...

Applied mechanics

  • 2018 - 2022
    • •
  • 4 563 tis. Kč
    • •
  • 4 563 tis. Kč
    • •
  • GA ČR
Project

Effect of ethanol and its principle metabolite acetaldehyde on cardiac inward rectifier potassium currents a link to atrial fibrillation related to alcohol consumption? (NT14301)

technique in isolated rat/guinea pig cardiomyocytes and in human channels transiently, and human cardiomyocytes, observed effects will be confronted with changes of action......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 3 369 tis. Kč
    • •
  • 3 229 tis. Kč
    • •
  • MZ
Project

Reprogramming of DMD-patient cells into cardiomyocytes - insights into molecular pathology of dilated cardiomyopathy (7AMB13FR011)

patients at different ages. Aim 2: Isolate cardiac RyR2 channels from properties of RyR2 macromolecular complex, Aim 3: Test drugs such as rycals (Ca channel conformation of RyR2 channels at a single cell and a single ...

EB - Genetika a molekulární biologie

  • 2013 - 2014
    • •
  • 108 tis. Kč
    • •
  • 108 tis. Kč
    • •
  • MŠMT
Project

Polymorphisms in promoters of ion channel genes and relationship to risk of malignant arrhythmias (NS10429)

The aim of this project is study of regulatory processes of human genome - to assess occurrence of polymorphisms in promoters of myocardial ion channel genes (KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2 and ANK2) in 30 patients with clinical ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2009 - 2011
    • •
  • 10 581 tis. Kč
    • •
  • 10 581 tis. Kč
    • •
  • MZ
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