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3 941 (0,099s) •

Project

Establishment and exploitation of human hepatocyte culture systems for the in vitro evaluation of drug metabolism (OC B15.40)

Establishment and exploitation of human hepatocyte culture systems for the in vitro evaluation of drug metabolism...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2002 - 2003
    • •
  • 1 848 tis. Kč
    • •
  • 1 271 tis. Kč
    • •
  • MŠMT
Project

Establishment and exploitation of human hepatocyte culture systems for the in vitro evaluation of drug metabolism (1P04OCB15.40)

Establishment and exploitation of human hepatocyte culture systems for the in vitro evaluation of drug metabolism...

FR - Farmakologie a lékárnická chemie

  • 2004 - 2004
    • •
  • 1 000 tis. Kč
    • •
  • 700 tis. Kč
    • •
  • MŠMT
Project

Role of glucocorticoid hormones in the Aryl hydrocarbon receptor cellular signalling in human hepatocytes (MEB040908)

The aim of the project is to examine molecular mechanisms of interactions between signaling pathways of glucocorticoid receptor and aryl hydrocarbon receptor (AhR) in primary cultures of human hepatocytes and cancer cell lines.......

FR - Farmakologie a lékárnická chemie

  • 2009 - 2010
    • •
  • 124 tis. Kč
    • •
  • 124 tis. Kč
    • •
  • MŠMT
Project

Effects of dehydroepiandrosterone (DHEA) on signallin pathways of energy metabolism in human hepatocytes (1P05OC063)

analysis of impacts of hormones DHEA and DHEA-S on signallin pathways regulating metabolism of main energetic substrates in human body...

FE - Ostatní obory vnitřního lékařství

  • 2005 - 2005
    • •
  • 638 tis. Kč
    • •
  • 426 tis. Kč
    • •
  • MŠMT
Project

Colchicinoids and 6-benzylaminpurine-type cytokines - their effect on expression of selected isoforms of cytochromes P450 in human liver cell cultures (GA303/99/P002)

isoforms (CYP 1A2, 3A4, 2C9, 2D6, 2E1) in human hepatocytes cultured in the form fractions of human hepatocytes.-benzylaminopurines on expression and activity of five cytochrome P450 isoforms in human

CE - Biochemie

  • 1999 - 2001
    • •
  • 558 tis. Kč
    • •
  • 558 tis. Kč
    • •
  • GA ČR
Project

Primary cultures of human hepatocytes as a model for toxicological, pharmacological and biochemical studies in transplantation medicine. (NT13591)

Primary cultures of human hepatocytes will be prepared and characterized using liver tissue obtained from multiorgan donors, for whom suitable recipient is not available. Primary cultures will be used for the study of liver-specific...

FJ - Chirurgie včetně transplantologie

  • 2012 - 2015
    • •
  • 6 162 tis. Kč
    • •
  • 6 162 tis. Kč
    • •
  • MZ
Project

Generation of hepatocyte-derived cellular models for preclinical testing of drugs (GAP304/10/0149)

Primary human hepatocytes are recommended in guidelines of many national drug availability of high-quality human hepatocytes, the interindividual variability of the project is to generate a cellular model(s) based ...

FR - Farmakologie a lékárnická chemie

  • 2010 - 2012
    • •
  • 4 499 tis. Kč
    • •
  • 4 499 tis. Kč
    • •
  • GA ČR
Project

Primary cultures of hepatocytes as a model for studies of cytoprotectivity of selected natural substances (NL5267)

Primary cultures of human hepatocytes will be used to study cytoprotectivity of natural substances against intoxication by tetrachloromethane,tert.butylhydroperoxide,galactosemine,doxorubicin,tacrite,and iron and its complexws with ...

FR - Farmakologie a lékárnická chemie

  • 1999 - 2001
    • •
  • 872 tis. Kč
    • •
  • 872 tis. Kč
    • •
  • MZ
Project

Selected natural compounds as protective agents against chemically induced human hepatocyte injury (GA303/98/0414)

The main aim of this project is to introduce human hepatocytes as a model for the study of xenobiotic metabolism and toxicity. Selected natural substances of current and potential use in the prevention and supportive therapy for liv...

FP - Ostatní lékařské obory

  • 1998 - 2000
    • •
  • 2 879 tis. Kč
    • •
  • 2 675 tis. Kč
    • •
  • GA ČR
Project

Dehydro-derivatives of the silymarin flavonolignans metabolism and biological activity (GA15-03037S)

biotransformations will be studied using several fecal/probiotic bacterial strains, human metabolically competent cells (hepatocytes, differentiated Caco-2 cells) and recombinant human drug-metabolizing enzymes. The effect...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2017
    • •
  • 8 052 tis. Kč
    • •
  • 8 052 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 3 941