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9 274 (0,125s) •

Project

Neural differentiation in microRNA induced pluripotent stem cells (NS10231)

This project concerns reprogramming somatic cells into pluripotent cells by micro RNA induction. Three cell lines will be transfected with miRNA. The success in reprogramming will be validated by reporter gene driv...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2011
    • •
  • 3 094 tis. Kč
    • •
  • 3 094 tis. Kč
    • •
  • MZ
Project

A new options in cardiomyogenic differentiation of pluripotent stem cells (GA18-18235S)

demand and effort for an alternate cardiomyocyte source. Pluripotent stem cells, especially induced pluripotent stem cell (iPSC) are relatively available source human heart to r...

Cell biology

  • 2018 - 2022
    • •
  • 4 547 tis. Kč
    • •
  • 4 424 tis. Kč
    • •
  • GA ČR
Project

Centrosomal abnormalities in human pluripotent stem cells. (GA15-11707S)

modalities based on stem cells (SCs). Enormous preclinical research effort is fueled by unprecedented properties of pluripotent embryonic SCs (ESCs) and their “man-made” counterpart – induced pluripotent ...

EA - Morfologické obory a cytologie

  • 2015 - 2019
    • •
  • 8 605 tis. Kč
    • •
  • 8 605 tis. Kč
    • •
  • GA ČR
Project

Evaluation of ion channels and receptors in human neural progenitors derived from induced pluripotent stem cells during motoneuronal differentiation (GA17-21146S)

indicated that differentiation of human induced pluripotent SCs (hiPSCs) toward mature neural cells, affects expression of ion channel and receptors which could playStem cells (SCs) of different ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2018
    • •
  • 2 755 tis. Kč
    • •
  • 2 608 tis. Kč
    • •
  • GA ČR
Project

The role of transcription factors Tcf in the induced cell pluripotency (iPS) and during neurogenesis (GAP305/12/2042)

Induced pluripotent stem (iPS) cells share characteristics with embryonic stem cells such as self-renewal and capability to differentiate into all cell types into pluripotent

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 8 747 tis. Kč
    • •
  • 8 747 tis. Kč
    • •
  • GA ČR
Project

Modeling DMD-related dilated cardiomyopathy using induced pluripotent stem cells-derived cardiomyocytes (GA13-19910S)

not always recapitulate the phenotype seen in patients. We hypothesize that DMD human induced-pluripotent stem cells (hiPS)-derived CMs represent an excellent ex vivo for fundamental stem cel...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 6 415 tis. Kč
    • •
  • 6 415 tis. Kč
    • •
  • GA ČR
Project

The role of FGF2 secretion in the physiology of human pluripotent stem cells (GA15-23033S)

Human pluripotent stem cells (hPSC), both embryonic and induced, represent a great tool for developmental studies, disease modeling and regenerative medicine. For their self-renewal, hPSC require active si...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 5 752 tis. Kč
    • •
  • 5 752 tis. Kč
    • •
  • GA ČR
Project

Experimental transplantation of the retinal pigmented epithelial cells in a large animal model (GA18-04393S)

The transplantation of retinal pigment epithelial (RPE) cells derived from human induced pluripotent stem cells (iPSC), is intensively studied as a promising macular degeneration. We aim this pro...

Ophthalmology

  • 2018 - 2021
    • •
  • 9 598 tis. Kč
    • •
  • 9 409 tis. Kč
    • •
  • GA ČR
Project

Interaction of biomaterials with stem cells under in vivo simulated conditions (GA19-16861S)

of their interactions with pluripotent stem cells (including induced human pluripotent stem cells, and electrical conductivity influence cell fate. Present knowledge on...

Materials engineering

  • 2019 - 2021
    • •
  • 7 540 tis. Kč
    • •
  • 7 540 tis. Kč
    • •
  • GA ČR
Project

Constructing the Developmental Atlas of Alzheimer’s Disease using Cerebral Organoids and Single-Cell Transcriptomics (GA24-12028S)

The proposed project aims to investigate the primary cause of Alzheimer's disease (AD) by utilizing cerebral organoids derived from human induced pluripotent stem cells (iPSCs) and single-cell tra...

Developmental biology

  • 2024 - 2026
    • •
  • 11 998 tis. Kč
    • •
  • 11 998 tis. Kč
    • •
  • GA ČR
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