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31 (0,083s) •

Project

The role of dietary cholesterol in regulation of gene expression in the model of dietary induced hypercholesterolemia (NR9401)

The expression of genes that respond to dietary cholesterol and those responsible for development of hypercholesterolemia will be studied in experimental model of diet induced hypercholesterolemia - Prague hereditary hypercholestero...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 4 928 tis. Kč
    • •
  • 4 857 tis. Kč
    • •
  • MZ
Project

Liver transplantation for hypercholesterolemia in experiment (ND4869)

Individuals with familial hypercholesterolemia will not live to be 20 years because of complications of atherosclerosis. The only successful therapeutic option is liver transplantation. The project analyzes the effect of orthotopic liver tra...

FJ - Chirurgie včetně transplantologie

  • 1998 - 1999
    • •
  • 1 623 tis. Kč
    • •
  • 1 295 tis. Kč
    • •
  • MZ
Project

Clinical and molecular genetic characteristics of patients with familial hypercholesterolemia in Czech Republic (NT14186)

Detailed characterization of patients with monogenic familial hypercholesterolemia including genetic, laboratory and clinical measures focusing on identification of predictors of cardiovascular risk.A......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2013 - 2015
    • •
  • 3 323 tis. Kč
    • •
  • 3 323 tis. Kč
    • •
  • MZ
Project

The role of nitric oxide in the pathogenesis of vaxcular disorders associated with hypercholesterolemia, hypertriglyceridemia and diabetes. (IZ4241)

The role of nitric oxide (NO) in atherogenesis will be investigated using models of metabolic diseases associated with increased risk of vascular disorders - hypercholesterolemia, insulin resistance and diabetes.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1997 - 1999
    • •
  • 2 037 tis. Kč
    • •
  • 1 513 tis. Kč
    • •
  • MZ
Project

The relationship of soluble endoglin and hypercholesterolemia in patients with type 2 diabetes mellitus and the impact of therapeutical intervention. (NV17-31754A)

pathological conditions related to hypercholesterolemia, diabetes mellitus (DM (90 with type 2 DM and 14 with Familial hypercholesterolemia). We aim to elucidate hypercholesterolemia. Supporting experimental study should g...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2020
    • •
  • 8 915 tis. Kč
    • •
  • 8 915 tis. Kč
    • •
  • MZ
Project

Prospective Study of Genetic Determination of Hypercholesterolemia (IZ3636)

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1996 - 1998
    • •
  • 863 tis. Kč
    • •
  • 862 tis. Kč
    • •
  • MZ
Project

Genetic and external determination of hypercholesterolemia and possibilities of treatment. (IZ120)

9G - 9

  • 1991 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MZ
Project

Long-term follow - up of the development of hypercholesterolemia in genetically characterized probands from childhood to adulthood. (NA6386)

Long-term monitoring of trends in cholesterolemia in genetically characterized probands from childhood to adulthood. Monitoring of the incidence of cardiovascular disease in the parents and grand-parents of probands. It will be continued in analysis ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2000 - 2002
    • •
  • 1 726 tis. Kč
    • •
  • 1 726 tis. Kč
    • •
  • MZ
Project

Influencing of an oxidative stress, risk of impaired glucose tolerance, type 2 diabetes mellitus and preclinical atherosclerosis by treatment of hyperlipidemias. (NB7377)

Possibilities of favourable influencing of mechanisms leading to impaired glucose tolerance and DM 2 development will be observed in yet untreated patients with primary hypercholesterolemia and/or hypertriglyceridemia by using the statins or...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2003 - 2005
    • •
  • 2 633 tis. Kč
    • •
  • 2 545 tis. Kč
    • •
  • MZ
Project

LDL gene score in the diagnosis of primary hypercholesterolemias and cardiovascular risk assessment (NV15-28277A)

Familial hypercholesterolemia (FH) is autosomal dominant disorder caused mostly by mutations in the LDL-receptor gene or the the gene encoding for apolipoprotein B. Prognosis of the affected patients differs even among carriers of the same m...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2018
    • •
  • 9 760 tis. Kč
    • •
  • 9 760 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 31