All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

8 (0,09s) •

Project

Mechanism of somatic hypermutation targeting in the B cell genome (GA22-30384S)

Somatic hypermutation (SHM) is a key process in diversification of antibodies, and modulation of their affinity in particular. This process is initiated by cytosine deamination by the activationinduced deaminase (AID) and completed by error-...

Cell biology

  • 2022 - 2024
    • •
  • 7 254 tis. Kč
    • •
  • 7 254 tis. Kč
    • •
  • GA ČR
Project

Mistargeting of somatic hypermutation and its role in B cell genome instability (GA15-24776S)

Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes in germinal center B cells during an immune response. The reaction is initiated by cytosine deamination by activation-induced deaminase (AID) and completed...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 4 771 tis. Kč
    • •
  • 4 771 tis. Kč
    • •
  • GA ČR
Project

Molecular characterization of adaptive antibiotic resistance and tolerance mechanisms of Staphylococcus aureus strains causing chronic infections (NV17-30460A)

resistance to antibiotics (persistence, target site mutation, hypermutability...

EE - Mikrobiologie, virologie

  • 2017 - 2020
    • •
  • 8 659 tis. Kč
    • •
  • 8 659 tis. Kč
    • •
  • MZ
Project

Characterization of B lymphocyte subpopulations in patients with common variable immunodeficiency. (NR9198)

1. Examination, quantification and more precise immunophenotypization of transitional and immature (CD21-) B cells in patients with CVID and comparison of the found proportions with the control group. 2. Evaluation of SHM frequency in rearranged Ig g...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2007 - 2009
    • •
  • 6 789 tis. Kč
    • •
  • 6 768 tis. Kč
    • •
  • MZ
Project

Targets and consequences of activation-induced cytidine deaminase-mediated mutagenesis in tumours (GN24-11338I)

Activation-induced cytidine deaminase (AID) causes mutations in immunoglobulin genes of activated B cells and is required for the production of high-affinity antibodies. However, AID also causes mutations in non-immunoglobulin genes, contributing to ...

Cell biology

  • 2024 - 2027
    • •
  • 6 323 tis. Kč
    • •
  • 6 323 tis. Kč
    • •
  • GA ČR
Project

Molecular detection and analysis of invasive small colony variants of S. aureus and resistant S. aureus strains from patients with cystic fibrosis (NT12395)

of resistance (resistance determinants, hypermutator phenotype) and virulence (superantigens...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2011 - 2015
    • •
  • 6 876 tis. Kč
    • •
  • 6 876 tis. Kč
    • •
  • MZ
Project

Disturbances of differentiation of B-lymphocytes in patients with defects of humoral immunity (NT11414)

The Ig-specific single-cell RT-PCR in B cells of patients with CVID, IgAD/IgMD will be used to analyze somatic hypermutation, affinity maturation/isotype switch, proliferation and activation, BCR signalling and differentiation stadium of B c...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2010 - 2014
    • •
  • 9 894 tis. Kč
    • •
  • 9 894 tis. Kč
    • •
  • MZ
Project

Clonal expansions in chronic lymphocytic leukemia – (epi)genomic characterization towards better disease understanding (NW24-03-00052)

concordant somatic hypermutation status of immunoglobulin variable gene IGHV that could...

Oncology

  • 2024 - 2027
    • •
  • 15 347 tis. Kč
    • •
  • 15 347 tis. Kč
    • •
  • MZ
  • 1 - 8 out of 8