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Projects

6 projects (0,125s) •

Project

Effects of non-invasive brain stimulation on hypokinetic dysarthria, micrographia, and brain plasticity in patients with Parkinson's disease (NV16-30805A)

Hypokinetic dysarthria (HD) is common in Parkinson’s disease (PD) patients and it responds only partially to pharmacotherapy and surgery of PD. We will explore short-term effects of repetitive transcranial magnetic stimulation (rTMS) applied over pre...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2019
    • •
  • 10 796 tis. Kč
    • •
  • 10 796 tis. Kč
    • •
  • MZ
Project

Home-based non-invasive brain stimulation in combination with Lee Silverman Voice Treatment on hypokinetic dysarthria in Parkinson’s disease (NU22J-04-00074)

Hypokinetic dysarthria (HD) is very common in Parkinson’s disease (PD), it is difficult to treat and affects patient communication in everyday life. We aim to assess a new combinatorial non-pharmacological approach that combines non-invasive brain st...

Clinical neurology

  • 2022 - 2025
    • •
  • 6 685 tis. Kč
    • •
  • 6 685 tis. Kč
    • •
  • MZ
Project

Speech disorders and analysis of their mechanisms in Parkinson's disease and other movement disorders. (NV15-28038A)

Speech is an important indicator of motor function and movement coordination and it can be extremely sensitive to involvement in the course of neurologic diseases, particularly those affecting basal ganglia. Acoustic analysis has the unique potential...

FH - Neurologie, neurochirurgie, neurovědy

  • 2015 - 2018
    • •
  • 8 151 tis. Kč
    • •
  • 8 151 tis. Kč
    • •
  • MZ
Project

Smart Speech Biomarkers for Parkinson’s Disease and Other Synucleinopathies (NU20-08-00445)

The early recognition of Parkinson’s disease (PD) and other synucleinopathies in prodromal stages has crucial implications for the future development of neuroprotective therapy. With no validated diagnostic biomarker, there is no way to identify peop...

Clinical neurology

  • 2020 - 2024
    • •
  • 15 467 tis. Kč
    • •
  • 15 467 tis. Kč
    • •
  • MZ
Project

Objective investigation of distinct speech phenotypes in newly diagnosed Parkinson's disease including effects of pharmacotherapy (NV19-04-00120)

Basal ganglia play an essential role in speech control including the selection of motor programs, speech execution, and sensory feedback mechanisms. Therefore, multidimensional speech impairment due to basal ganglia dysfunction is detectable in up to...

Clinical neurology

  • 2019 - 2022
    • •
  • 10 811 tis. Kč
    • •
  • 10 811 tis. Kč
    • •
  • MZ
Project

Investigating evolution of speech disorder in Parkinson's disease via objective acoustic analysis (NW24-04-00211)

Without validated biomarkers, there is no way to identify people at risk for Parkinson’s disease (PD) or to establish strategies for its prevention. Speech is highly susceptible to neurodegeneration. Tracking speech disorder via objective acoustic an...

Clinical neurology

  • 2024 - 2027
    • •
  • 15 260 tis. Kč
    • •
  • 15 260 tis. Kč
    • •
  • MZ
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