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4 046 (0,125s) •

Project

DNA typing of HLA class I in transplantation medicine (IZ4195)

Human Leukocyte Antigen (HLA) Class I typing at the level of DNA using a method based on polymorphic system amplification (PCR-SSP, -ARMS) in donors and recipients in organ and bone marrow transplantation.......

FJ - Chirurgie včetně transplantologie

  • 1997 - 1999
    • •
  • 1 512 tis. Kč
    • •
  • 1 376 tis. Kč
    • •
  • MZ
Project

Gene immunotherapy of tumours with different expression of MHC-I. (NC5900)

Induction of immunity against tumours cells producing HPV16 E7 oncoprotein and differing in the degree of MHC-I expression.Combination of DNA immunization and immunization with transduced tumour cells. Enhancement of immune response...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 9 325 tis. Kč
    • •
  • 8 670 tis. Kč
    • •
  • MZ
Project

Shaping the genome How environmental factors affect the DNA content evolution in populations of planktonic algae? (GN23-05546O)

substantial intraspecific DNA content variation. I will quantify the competitive abilities of conspecific strains with different DNA contents in a variety of ecological contexts, in unlimited and (nutrient-/ temperature-) ...

Marine biology, freshwater biology, limnology

  • 2023 - 2026
    • •
  • 4 865 tis. Kč
    • •
  • 4 865 tis. Kč
    • •
  • GA ČR
Project

Deciphering Origins of DNA replication in genome integrity (GM22-20303M)

is poorly understood. I have recently discovered a molecular pathway that couples pre-RC assembly with proper DNA replication dynamics. Building on these findings, I proposeDNA replication is fundamental to cell p...

Cell biology

  • 2022 - 2026
    • •
  • 24 928 tis. Kč
    • •
  • 24 928 tis. Kč
    • •
  • GA ČR
Project

Evolutionary conserved structural features of centromeric and telomeric DNA (GA13-28310S)

of centromeric and telomeric DNA from Saccharomyces cerevisiae, Arabidoptis thaliana. These studies will provide information on: i) formation and proportional representation of non-canonical (non-B) DNA motifs in centromer...

BO - Biofyzika

  • 2013 - 2016
    • •
  • 6 882 tis. Kč
    • •
  • 6 882 tis. Kč
    • •
  • GA ČR
Project

Structure, dynamics and function of DNA (GA203/00/0633)

) simulations of hydrated nucleic acids will be used to study the DNA molecules with a special attention paid to the following three areas: (i) Structure, dynamics and folding of unusual NAstructures, such as i-DNA...

CF - Fyzikální chemie a teoretická chemie

  • 2000 - 2002
    • •
  • 2 624 tis. Kč
    • •
  • 1 260 tis. Kč
    • •
  • GA ČR
Project

Understanding of binding of RNA polymerace I transcription factor xUBF to DNA (IAA5004105)

Xenopus upstream binding factor (UBF) is an RNA polymerase I-specific transcription factor of ribosomal genes, containing five DNA binding domains (HMG box) which form DNA crossorvers, and to induce DNA bending and...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 181 tis. Kč
    • •
  • 1 373 tis. Kč
    • •
  • AV ČR
Project

Atomically resolved in vivo NMR spectroscopy as a novel tool for biological testing of therapeutically important genomic non-canonical DNA targets and their interactions with drugs in phenotypically (NV19-08-00450)

Non-canonical DNA structures in regulatory regions of the human genome, such as DNA i-motifs, DNA G-quadruplexes, and mismatch/abasic sites containing double stranded DNAs, are important therapeutic target...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 13 449 tis. Kč
    • •
  • 13 449 tis. Kč
    • •
  • MZ
Project

Detection and characterization of "blank" HLA class 1 alleles in the Czech population. Implications for transplant medicine (NM6522)

Examination of "blank" HLA class I alleles - using DNA sequencing and flow cytometry to determine their frequency and to analyze HLA molecule expression on cell surface - in the healthy Czech population and in patients awaiting orga...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 2 749 tis. Kč
    • •
  • 2 583 tis. Kč
    • •
  • MZ
Project

Involvement of nuclear HMGB proteins in sensitizing of human cells to anticancer drugs inhibiting DNA topoisomerases (GAP301/10/0590)

Separation of the two DNA strands results in superhelical tension resolved relationship between HMGB-type proteins, tumor suppressor pRb and DNA topoisomerases (Štros of topoisomerases I and II (topo) by HMGB-type proteins ...

FD - Onkologie a hematologie

  • 2010 - 2012
    • •
  • 4 859 tis. Kč
    • •
  • 4 859 tis. Kč
    • •
  • GA ČR
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