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216 (0,085s) •

Project

Mistargeting of somatic hypermutation and its role in B cell genome instability (GA15-24776S)

Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes in germinal center B cells during an immune response. The reaction is initiated by cytosine deamination by activation-induced deaminase (AID) and completed...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 4 771 tis. Kč
    • •
  • 4 771 tis. Kč
    • •
  • GA ČR
Project

Aberrant plasma cells clonal diversification in immunoglobulin light chain amyloidosis (NV15-29667A)

Immunoglobulin light chain amyloidosis (ALA) is a haematological disorder and may coexist with other plasma cell (PC) dyscrasias. It has been reported that 10% of ALA patients may have multiple myeloma (MM) at the same time. Nevertheless be ...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 8 743 tis. Kč
    • •
  • 8 623 tis. Kč
    • •
  • MZ
Project

Mechanism of somatic hypermutation targeting in the B cell genome (GA22-30384S)

Somatic hypermutation (SHM) is a key process in diversification of antibodies, and modulation of their affinity in particular. This process is initiated by cytosine deamination by the activationinduced deaminase (AID) and completed by error-...

Cell biology

  • 2022 - 2024
    • •
  • 7 254 tis. Kč
    • •
  • 7 254 tis. Kč
    • •
  • GA ČR
Project

Innovative method of immunoglobulins administration (TJ04000443)

immunoglobulins. We assume w/o/w double emulsion enables the protection of immunogobulins gastrointestinal tract simulation. Furthermore, the release of immunoglobulins from the w/o/w immunoglobulins are required. Immu...

Chemical process engineering

  • 2020 - 2022
    • •
  • 3 799 tis. Kč
    • •
  • 3 209 tis. Kč
    • •
  • TA ČR
Project

Investigation of regulatory components of the immunoglobulin translation machinery in multiple myeloma as novel therapeutic targets (GA22-26981S)

Malignant transformation of plasma cells leads to the development of multiple myeloma. The tremendous production of immunoglobulin is a typical myeloma hallmark of the ubiquitin system, particularly deubiquitinase OTUD1, in the immunoglo...

Cell biology

  • 2022 - 2024
    • •
  • 9 065 tis. Kč
    • •
  • 9 065 tis. Kč
    • •
  • GA ČR
Project

Identification of immunoglobulin and T-cell receptor genes rearrangements for detection of clonality and residual disease in lymphoid malignancies. (IZ3425)

The analysis of clonospecific rearrangements of T-cell receptor and immunoglobulin genes will improve the diagnosis of non Hodkin s lymphomas and monitoring of minimal residual disease in acute lymphoblastic leukemias in children.......

FG - Pediatrie

  • 1996 - 1999
    • •
  • 3 745 tis. Kč
    • •
  • 3 745 tis. Kč
    • •
  • MZ
Project

Cytokines in relationship to immunoglobulin production in multiple sclerosis. (IZ2777)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1995 - 1997
    • •
  • 1 155 tis. Kč
    • •
  • 1 155 tis. Kč
    • •
  • MZ
Project

Preparation of immunoglobulins with defined specificities from milk, colostrum or eggs of immunized donors (EP0960006625)

on the development and testing of methods of careful separation of immunoglobulins from small. Instructions for use of the immunoglobulins in the preapration of diagnostic reagents......

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 1996 - 2000
    • •
  • 5 546 tis. Kč
    • •
  • 4 946 tis. Kč
    • •
  • MZe
Project

How to recognize evolutionary cradles and dead-end lineages? The devil, the details, and species diversification inference (GN24-12851O)

Species diversification is a key process for explaining fundamental, the methodological tools for studying species diversification are fairly divergent the association between species characteristics and diversification. I ...

Ecology

  • 2024 - 2027
    • •
  • 5 645 tis. Kč
    • •
  • 5 645 tis. Kč
    • •
  • GA ČR
Project

Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis (GP309/02/D066)

The goals of the project Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis are as follows: 1) to confirm the significance of the determination of free light chains of immunoglobulins ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2005
    • •
  • 72 tis. Kč
    • •
  • 47 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 216