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The role of steroids as modulators of internal milieu in human semen fluid; a contribution to the endocrinology of male reproduction. (NB6890)
Immunomodulatory and immunosuppressive steroids, together with relevant cytokines, will be determined in ejaculate and blood of healthy men and in men with sexual disorders and impairment of fertility. The answer to the question is ...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2002 - 2004 •
- 3 466 tis. Kč •
- 3 466 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2002 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Influence of smoking and its cessation on endocrine system (NR9055)
In common steroids, the effect of smoking was investigated but in neuroactive steroids there are a nuber of metabolic pathawas that were not examined. Nicotine the effect that was formerly found in C19 steroids in C21 s...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2006 - 2009 •
- 6 948 tis. Kč •
- 6 380 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2006 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (92%)
Poskytovatel: Ministerstvo zdravotnictví
Neuroactive steroids, imunomodulatory steroids and ergosteroids in pregnancy and around parturition. (NB7070)
Verification of the role of GABA-receptor activators in maintenance of pregnancy, elicitation of parturition and postpartum complications will contribude to their potential therapeutical application. We intend to investigate the profile of the substa...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2002 - 2004 •
- 2 928 tis. Kč •
- 2 894 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2002 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
Hormonal alterations in patients with multiple sclerosis (NU20-04-00450)
and progression of MS indicate participation of sex steroids in MS pathophysiology. In late and increases again after delivery due to the decrease of the steroid levels. Animal studies have shown that dehydroepiandrosterone (DHEA) ...
Clinical neurology
- 2020 - 2024 •
- 6 956 tis. Kč •
- 6 699 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2020 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (96%)
Poskytovatel: Ministerstvo zdravotnictví
Search for immunomodulatory steroids synthesis of 7,16-dihydroxydehydroepiandrosterone and derived haptens (GA203/03/0142)
for radioimmunoassays. The analysis of polyhydroxylated steroids of this type is importantfor...
CC - Organická chemie
- 2003 - 2004 •
- 2 372 tis. Kč •
- 664 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2003 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (28%)
Poskytovatel: Grantová agentura České republiky
Gene screening of actinomycetes producing new substances with potential therapeutic applications to modulate immune mechanisms. (IAA600660607)
The project aims to acquire new secondary metabolites of the manumycin type from soil-isolated actinomycetes. These non-steroidal compounds show interesting immunomodulatory features (IL-1ß convertase inhibition) that could potentia...
EE - Mikrobiologie, virologie
- 2006 - 2008 •
- 4 337 tis. Kč •
- 4 337 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2006 - 31. 12. 2008
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Akademie věd České republiky
Relationships of steroid metabolism to the patogenesis and treatment of epilepsy (1A8649)
endocrinopathies influencing at least the course of epilepsy. Some circulating steroids surpass produced steroids, modulate also the ionotropic membrane receptors of neuronal cells influencing the neuronal activity. We will concent...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2005 - 2009 •
- 8 286 tis. Kč •
- 8 188 tis. Kč •
- MZ
Řešení projektu: 1. 8. 2005 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
The role of steroid sulfates in steroid metabolism and their diagnostic meaning. (NB5398)
Investigation of influencing the kinetics of formation and matabolism of steroid sulfates by free radical scavengers and diagnostic utilization of possible relation between autoimunne diseases and plasma levels of steroid sulfates.....
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 1999 - 2001 •
- 2 377 tis. Kč •
- 1 888 tis. Kč •
- MZ
Řešení projektu: 1. 1. 1999 - 1. 1. 2001
Uznané náklady
Podpora ze státního rozpočtu (79%)
Poskytovatel: Ministerstvo zdravotnictví
The smoking cessation and hormonal homeostasis oriented to neuroactive steroids (NS10215)
The influence of smoking on the biosynthesis of steroids is still not fully enzyme of the synthesis of neuroactive steroids. We shall focus on the influence of smoking on the synthesis of neuroprotective and immunomodulating 7-hydro...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2009 - 2011 •
- 4 441 tis. Kč •
- 4 441 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
To the role of neuroactive steroids Their metabolism and its influencing under physiological and pathological conditions (NB6702)
The proposed grant is studying the interactions between the levels of neuroactive steroids and homocysteine in physiological and pathological conditions and the influence of exogenous and endogenous factors on the activity of steroidogenic, ...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2001 - 2003 •
- 2 262 tis. Kč •
- 1 956 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2001 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (86%)
Poskytovatel: Ministerstvo zdravotnictví
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