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6 365 (0,287s) •

Project

Neural differentiation in microRNA induced pluripotent stem cells (NS10231)

This project concerns reprogramming somatic cells into pluripotent cells by micro RNA induction. Three cell lines will be transfected with miRNA. The success in reprogramming will be validated by reporter gene driv...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2011
    • •
  • 3 094 tis. Kč
    • •
  • 3 094 tis. Kč
    • •
  • MZ
Project

The role of transcription factors Tcf in the induced cell pluripotency (iPS) and during neurogenesis (GAP305/12/2042)

Induced pluripotent stem (iPS) cells share characteristics with embryonic stem cells such as self-renewal and capability to differentiate into all cell types into pluripotent

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 8 747 tis. Kč
    • •
  • 8 747 tis. Kč
    • •
  • GA ČR
Project

A new options in cardiomyogenic differentiation of pluripotent stem cells (GA18-18235S)

demand and effort for an alternate cardiomyocyte source. Pluripotent stem cells, especially induced pluripotent stem cell (iPSC) are relatively available source......

Cell biology

  • 2018 - 2022
    • •
  • 4 547 tis. Kč
    • •
  • 4 424 tis. Kč
    • •
  • GA ČR
Project

Modeling DMD-related dilated cardiomyopathy using induced pluripotent stem cells-derived cardiomyocytes (GA13-19910S)

induced-pluripotent stem cells (hiPS)-derived CMs represent an excellent ex vivo for fundamental stem cell research, studies of disease and drug screening.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 6 415 tis. Kč
    • •
  • 6 415 tis. Kč
    • •
  • GA ČR
Project

Centrosomal abnormalities in human pluripotent stem cells. (GA15-11707S)

modalities based on stem cells (SCs). Enormous preclinical research effort is fueled by unprecedented properties of pluripotent embryonic SCs (ESCs) and their “man-made” counterpart – induced pluripotent ...

EA - Morfologické obory a cytologie

  • 2015 - 2019
    • •
  • 8 605 tis. Kč
    • •
  • 8 605 tis. Kč
    • •
  • GA ČR
Project

Evaluation of ion channels and receptors in human neural progenitors derived from induced pluripotent stem cells during motoneuronal differentiation (GA17-21146S)

Stem cells (SCs) of different origins have brought hope for the treatment of neurodegenerative diseases such as Alzheimer’s disease (AD) and Amyotrophic Lateral Sclerosis indicated that differentiation of human induced ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2018
    • •
  • 2 755 tis. Kč
    • •
  • 2 608 tis. Kč
    • •
  • GA ČR
Project

Fam208a-associated epigenetic silencing and the maintenance of embryonic stem cell pluripotency (GA17-16959S)

is essential for the self-renewal of pluripotent stem cells. Using genetically modified embryonic stem cell models, we will employ several next generation sequencing-based and maintenance of the pluri...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 9 171 tis. Kč
    • •
  • 8 115 tis. Kč
    • •
  • GA ČR
Project

Improved Interpretation of Next Generation Sequencing Datasets in Patients with Inherited Cardiomyopathy Using Functional Models Based on Induced Pluripotent Stem Cells and Advanced Cardiac Imaging (NV19-08-00122)

cardiomyocyte models based on induced pluripotent stem cells and test these cultures using...

Cell biology

  • 2019 - 2023
    • •
  • 15 852 tis. Kč
    • •
  • 15 852 tis. Kč
    • •
  • MZ
Project

Interaction of biomaterials with stem cells under in vivo simulated conditions (GA19-16861S)

of their interactions with pluripotent stem cells (including induced human pluripotent stem cells, and electrical conductivity influence cell fate. Present knowledge on the inte...

Materials engineering

  • 2019 - 2021
    • •
  • 7 540 tis. Kč
    • •
  • 7 540 tis. Kč
    • •
  • GA ČR
Project

The role of FGF2 secretion in the physiology of human pluripotent stem cells (GA15-23033S)

Human pluripotent stem cells (hPSC), both embryonic and induced, represent a great tool for developmental studies, disease modeling and regenerative medicine. For their self-renewal, hPSC require active signaling p...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 5 752 tis. Kč
    • •
  • 5 752 tis. Kč
    • •
  • GA ČR
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