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72 (0,083s) •

Project

Screening for genetic determinants of oligo/teratozoospermia in infertile men, informed by data from animal models (NT12269)

Infertility is a compelling health problem. According to a recent meta-analysis, in average 9% of couples are infertile. Male factor is responsible for approximately half be distinguished. Work on animal genetically defined models o...

EB - Genetika a molekulární biologie

  • 2011 - 2015
    • •
  • 7 732 tis. Kč
    • •
  • 7 732 tis. Kč
    • •
  • MZ
Project

Significance of anti-annexin V antibodies in couples with infertility failures (NH7400)

Creation of ELISA test for detection of anti-annexin V antibodies in couples with infertility failures, comparison with seven antiphospholipid antiphospholipid antibodies. Comparison of serum anti-annexin V antibodies with the same antibodie...

FK - Gynekologie a porodnictví

  • 2003 - 2005
    • •
  • 1 796 tis. Kč
    • •
  • 1 779 tis. Kč
    • •
  • MZ
Project

Proteomic and genetic assessment of sperm quality for the enhancement of assisted reproduction in infertile patients with diabetes mellitus (NV15-30880A)

The increasing frequency of infertility has become a major public health concern. Male infertility is the primary or contributing cause in approximately 60) is suspected to be a contributing factor in male infertility. Incr...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2018
    • •
  • 10 948 tis. Kč
    • •
  • 10 948 tis. Kč
    • •
  • MZ
Project

Molecular biological aspects of the sperm head-tail coupling apparatus in normal and hd mutant rats (ME10034)

In most developed countries, about 15% of couples are infertile. About half provides powerful tools for infertility management, certain conditions are associated with a poor outcome of male infertility treatment. Moreover, ...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 800 tis. Kč
    • •
  • 1 800 tis. Kč
    • •
  • MŠMT
Project

Spermatogenesis impairment in the rats carrying the mutant allele hd analysis of molecular function of both normal and mutant allele of the LOC303240 (GP301/07/P178)

More than 15% couples worldwide suffer from infertility, with substantial fraction ascribed to male infertility. Male infertility has frequently genetic and even mendelian basis, but the etiology can be rarely assessed dire...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 1 440 tis. Kč
    • •
  • 1 440 tis. Kč
    • •
  • GA ČR
Project

Detection of mutations in genes coding key embryo-endometrium crosstalk cytokines in idiopathicly infertile women with repeated failure of treatment (GA301/05/0078)

Current epidemiological data suggest that 15% of couples experience infertility and in half this number the problem remains unresolved. The necessary condition part, which of the NK cells seem to play an important role. Group of infertil...

FK - Gynekologie a porodnictví

  • 2005 - 2007
    • •
  • 2 205 tis. Kč
    • •
  • 2 205 tis. Kč
    • •
  • GA ČR
Project

Impact of homocysteine metabolism on human infertility (NS9661)

To improve knowledge about pathological homocysteine metabolism and relation to oxidative stress, gonadal function and DNA structure of human germinal cells. To analyze predictive value of homocysteine, oxidative stress and sperm chromatine integrity...

FK - Gynekologie a porodnictví

  • 2008 - 2011
    • •
  • 2 544 tis. Kč
    • •
  • 2 544 tis. Kč
    • •
  • MZ
Project

Oxidative stress in pathophysiology of male infertility. (1A8621)

Implementation of measurement of oxidative stress into the routine diagnostics of male factor infertility. Determination of chosen species of ROS/RNS in spermatozoa; discrimination of cell origin of chosen ROS by flow-cytometry. Evaluation o...

FK - Gynekologie a porodnictví

  • 2005 - 2009
    • •
  • 4 646 tis. Kč
    • •
  • 4 620 tis. Kč
    • •
  • MZ
Project

Relation between polymorphism of proinflamatory cytokine genes and male fertility (NR8064)

Aim of the project is exact definition of relation and predictive value of gene polymorphism of proinflamatory cytokines TNF-alfa, TNF-beta and TACE to male infertility.......

FK - Gynekologie a porodnictví

  • 2004 - 2006
    • •
  • 1 079 tis. Kč
    • •
  • 864 tis. Kč
    • •
  • MZ
Project

The identification and the characterization of the leukemia-inhibitory factor gene mutations in the population of women with idiopathic infertility (GA301/02/1232)

The idiopathic infertility occurs in 10 to 15 % of infertile couples. One of its causes is the embryo implantation failure, which can also lead to relatively low pregnancy rates of routinely used assisted reproduction techniques. Th...

FK - Gynekologie a porodnictví

  • 2002 - 2004
    • •
  • 1 700 tis. Kč
    • •
  • 1 700 tis. Kč
    • •
  • GA ČR
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