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223 (0,208s) •

Project

Identification and characterization of genetic factors contributing to inherited tubulointerstitial kidney disease (NV17-29786A)

Autosomal dominant tubuloinsterstitial kidney diseases (ADTKD) are characterized by autosomal dominant inheritance, pathologic tubular changes and interstitial fibrosis resulting in slowly progressive chronic kidney disease. There are four m...

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 11 703 tis. Kč
    • •
  • 11 703 tis. Kč
    • •
  • MZ
Project

Identification and characterization of genetic factors contributing to inherited tubulointerstitial kidney disease II (NU21-07-00033)

to a clinical syndrome characterized by autosomal dominant inheritance, pathologic tubular most common cause of inherited kidney disease after autosomal dominant polycystic families with various forms of inherited kidney d...

Human genetics

  • 2021 - 2024
    • •
  • 12 754 tis. Kč
    • •
  • 12 754 tis. Kč
    • •
  • MZ
Project

Identification and characterization of genetic causes of hereditary tubulointerstitial kidney diseases (LUAUS24087)

The aim of the project is to use biochemical and genomic methods to determine genetic causes, clarify the basic biological mechanisms associated with found genetic variants and the definition of basic pathological processes leading to genetically con...

Genetics and heredity (medical genetics to be 3)

  • 2024 - 2028
    • •
  • 9 970 tis. Kč
    • •
  • 9 970 tis. Kč
    • •
  • MŠMT
Project

European structure for coordination of research and diagnosis of inherited purine and pyrimidine disorders (OK 352)

)To participate on mapping the gene for familial juvenile hyperuricemic nephropathy...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2001
    • •
  • 1 450 tis. Kč
    • •
  • 1 400 tis. Kč
    • •
  • MŠMT
Project

The expression of proinflammatory genes in patients with IgA nephropathy and their relation to the disease outcome (NR8913)

Determine correlation among intrarenal expression of MCP-1, RANTES, TGF-beta1, HGF and BMP genes, infiltration of leukocyte into renal tissue, proteinuria and short term otcome of IgA nephropathy. Find out if patients with genotype related a...

FE - Ostatní obory vnitřního lékařství

  • 2006 - 2009
    • •
  • 4 966 tis. Kč
    • •
  • 4 432 tis. Kč
    • •
  • MZ
Project

The role of vasoactive humoral systems in pathogenesis of diabetic nephropathy. (NB6365)

The aims of the project are a) to test the regulation of selected vasoactive humoral systems and their role in the pathogenesis of diabetic nephropathy in type I diabetic patients and healthy subjects and b) to evalute the possibilities of r...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 6 135 tis. Kč
    • •
  • 6 135 tis. Kč
    • •
  • MZ
Project

Cyclooxygenase-2 polymorphisms and the development of nephropathy in diabetes (NR9368)

Using molecular biological techniques we will study -765GC polymorphisms in COX-2 gene and their possible impact on monocytic COX-2 phenotype in diabetic patients with nephropathy in comparison with patients without DN and healthy subjects.....

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 3 446 tis. Kč
    • •
  • 3 386 tis. Kč
    • •
  • MZ
Project

Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy (NR9443)

The project aims to optimise early diagnostics of diabetic nephropathy by means of genetic analysis of transketolase and transaldolase genes and to allow individualised follow-up of diabetics and, eventually, even individualised therapeutic ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 3 846 tis. Kč
    • •
  • 3 846 tis. Kč
    • •
  • MZ
Project

Factors affecting the course of IgA nephropathy – the most common primary glomerulonephritis. (LH15168)

We propose to develop noninvasive diagnostic tests for detection of subclinical types of IgA nephropathy, evaluation of disease activity, and assessment of treatment effectiveness. Consequently, these tests will allow to avoid repeat renal b...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 1 896 tis. Kč
    • •
  • 1 896 tis. Kč
    • •
  • MŠMT
Project

New mode of treatment of IgA nephropathy and the ways of monitoring (IZ4216)

The evaluation of the role of prostanoids in treatment of IgA nephropathy using fish oil is the main target of the project.During the one year s treatment with fish oil levels of prostanoids and cytokines will be monitored.......

FE - Ostatní obory vnitřního lékařství

  • 1997 - 1999
    • •
  • 1 841 tis. Kč
    • •
  • 1 620 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 223