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1 327 (0,173s) •

Project

Insulin mimetics (GA14-17305S)

published first crystal structures of insulin bound to truncated insulin receptor. We of compounds mimicking three noncontiguous receptor-binding epitopes in insulin moleculeInsulin is a protein ...

FR - Farmakologie a lékárnická chemie

  • 2014 - 2016
    • •
  • 7 721 tis. Kč
    • •
  • 7 721 tis. Kč
    • •
  • GA ČR
Project

The role of T- and R-conformations of insulin in binding to the insulin receptor (GPP207/11/P430)

. Insulin is known to act through binding to the insulin receptor (IR); howeverInsulin is a protein hormone that plays a key role in regulation of blood of insulin represent only inactive storage forms. It...

CE - Biochemie

  • 2011 - 2013
    • •
  • 2 554 tis. Kč
    • •
  • 2 554 tis. Kč
    • •
  • GA ČR
Project

Atomistic Understanding of Peptide Hormone Binding to Their Receptors and Mimetics Design via Advanced Computations and Experimental Verification (GA23-06755S)

Insulin and its analogs are life-saving molecules for diabetes patients, the quest for non-peptidic small molecules, insulin mimetics, is urgent. Major breakthroughs in the cryo-EM methodology yielded several structures of insul...

Physical chemistry

  • 2023 - 2025
    • •
  • 6 741 tis. Kč
    • •
  • 6 625 tis. Kč
    • •
  • GA ČR
Project

New full-length analogs of human insulin with modifications in positions B24-B26. (KJB400550702)

to the insulin receptor. The most interesting insulin analogs will be tested the role of insulin residues B24-B26 in the interaction with insulin receptor. SomeThe aim of the project is the synth...

CE - Biochemie

  • 2007 - 2009
    • •
  • 2 320 tis. Kč
    • •
  • 2 320 tis. Kč
    • •
  • AV ČR
Project

Role of renin-angiotensin system in pathophysiology of insulin resistance (NR8821)

To test in vivo the effect of acutely-induced hyperinsulinaemia/or AT receptor blockade (losartan) on plasma concentrations of selected adipokines and their expressions in subcutaneous adipose tissue in type 2 diabetes and healthy subjects. ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
    • •
  • 10 383 tis. Kč
    • •
  • 9 421 tis. Kč
    • •
  • MZ
Project

Molecular mechanisms of the etiology of non-insulin dependent diabetes mellitus (NIDDM) (OC B5.10)

The action deals with cellular mechanisms underlying insulin resistance phenomena and with their clinical consequences that manifest themselves, in their most developed forms, as the type II or the non-insulin-dependent diabetes mel...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1994 - 1999
    • •
  • 1 440 tis. Kč
    • •
  • 1 245 tis. Kč
    • •
  • MŠMT
Project

Study of the genetic background of the polycystic ovary syndrome (GA301/04/1085)

receptor, sex hormone binding globulin, insulin variable number of tandem repeats, insulin receptor, insulin receptor substrate 2, peroxisome proliferator activator and hirsutism. The genetic bac...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 4 460 tis. Kč
    • •
  • 4 454 tis. Kč
    • •
  • GA ČR
Project

Signal transduction of angiotensin II in diabetes mellitus and its modulation by glucose, insulin a insulin resistance (NR8221)

signalingin diabetes and their synergism with insulin and glucose signaling. Using animal receptor, factors important for smooth Ang II signaling. Furthermore, we will determine activities of signaling cascades that are activated b...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 5 049 tis. Kč
    • •
  • 4 585 tis. Kč
    • •
  • MZ
Project

Acute and chronic effects of non-peptide angiotensin II receptor antagonist and angiotensin converting enzyme inhibitor on blood pressure,insulin sensitivity an (IZ3059)

FR - Farmakologie a lékárnická chemie

  • 1995 - 1997
    • •
  • 1 008 tis. Kč
    • •
  • 955 tis. Kč
    • •
  • MZ
Project

Analysis of mechanisms of adipokine autocrine effects on glucose and lipid metabolism (IAA500110805)

The role of endocrine function of adipose tissue in the pathogenesis of insulin insulin action and subsequently in the pathogenesis of insulin resistance the expression of genes involved in the pathogenesis of obesity and <...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 5 064 tis. Kč
    • •
  • 5 064 tis. Kč
    • •
  • AV ČR
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