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942 (0,07s) •

Project

Study of the interaction of adenylate cyclase toxin with the integrin receptor CD11b/CD18 (GP204/07/P105)

the ACT-binding domain of the integrin receptor CD11b/CD18 using a set of genetically is mediated through the integrin receptor CD11b/CD18. Nevertheless, the mechanism......

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 1 389 tis. Kč
    • •
  • 1 389 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase (IAA5020406)

in binding of ACT to the CD11b integrin receptor will be defined and the oligomeric...

CE - Biochemie

  • 2004 - 2008
    • •
  • 6 250 tis. Kč
    • •
  • 5 910 tis. Kč
    • •
  • AV ČR
Project

Materials with nanostructured surface for biomedical applications (GA16-02702S)

analogous ligands for cell receptors (integrins), with adequate molecular structure procedures that would allow the material surface to be modified for binding of peptide integrin clustering. Polydopamine-poly(ethylene oxi...

CD - Makromolekulární chemie

  • 2016 - 2018
    • •
  • 6 111 tis. Kč
    • •
  • 5 574 tis. Kč
    • •
  • GA ČR
Project

Expression of integrins during differentiation of Schwann cells and derivative structures of the peripheral nervous system of the rat (GA309/97/0107)

). Integrins involved in interactions between the cell and ECM have probably crucial of: i/ integrin expressions during glial cell differentiation in the PNS of prenatal and integrin expression; iii/ a function of integ...

EA - Morfologické obory a cytologie

  • 1997 - 1999
    • •
  • 2 016 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
Project

Structural and functional analysis of interaction between calmodulin and plectin isoform 1a (7AMB13AT012)

of the interaction between the calmodulin and the N-terminal actin binding domain of plectin and integrin - analysis of the disassembly mechanism of intergrin-plectin complex after binding of calmodulin iii) To address the...

EB - Genetika a molekulární biologie

  • 2013 - 2014
    • •
  • 170 tis. Kč
    • •
  • 170 tis. Kč
    • •
  • MŠMT
Project

Study of synergisms of anticancer drug ellipticine and alfa5 beta1 integrin in brain cancer treatment (MEB020837)

The target of the project is investigation of synergisms of anticancer drug ellipticine and alfa5 beta1 integrin, which can be utilized in treatment of cancer such as brain tumors.......

CE - Biochemie

  • 2008 - 2009
    • •
  • 29 tis. Kč
    • •
  • 29 tis. Kč
    • •
  • MŠMT
Project

Artificial fibronectin-mimetic ligands for integrin-mediated cell adhesion to biomaterials (KJB400500904)

effective cell adhesion via integrin receptors only if the structures mediating interaction with integrins, e.g. RGDS and PHSRN peptide motifs, are attached in a particular distance, distributed in domains that make possible cluste...

CD - Makromolekulární chemie

  • 2009 - 2011
    • •
  • 2 471 tis. Kč
    • •
  • 2 471 tis. Kč
    • •
  • AV ČR
Project

Interaction of adenylate cyclase toxin with complement receptor 3 (GAP302/11/0580)

The adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis that binds host myeloid phagocytic cells through the beta-2 integrin CD11b/CD18 (complement receptor 3). The mechanism of ...

EB - Genetika a molekulární biologie

  • 2011 - 2015
    • •
  • 12 958 tis. Kč
    • •
  • 12 958 tis. Kč
    • •
  • GA ČR
Project

Membrane transport of non-transferrin iron in mammalian cells (IAA5052702)

and their combination: 1. iron-binding proteins of solubilized membranes will be detected...

EB - Genetika a molekulární biologie

  • 1997 - 2001
    • •
  • 3 283 tis. Kč
    • •
  • 1 750 tis. Kč
    • •
  • AV ČR
Project

The role of adhesion molecules in the regulation of TRAIL-induced apoptosis (KJB5052407)

molecules - integrins and their regulations partner for studiing influence of integrin and signailing pathways involved in integrin regulation of TRAIL-induced apoptosis selection and a role of integrins in its re...

EB - Genetika a molekulární biologie

  • 2004 - 2005
    • •
  • 926 tis. Kč
    • •
  • 436 tis. Kč
    • •
  • AV ČR
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