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7 515 (0,078s) •

Project

Study of Mechanism of Molecular Recognition Application to Analytical and Medicinal Chemistry (VS97135)

structures for study of specific interaction with DNA, regulatory proteins and viral (dystamicin) and tested as novel antiviral drugs. The mechanism of interaction knowledge of DNA and protein binding sid...

CB - Analytická chemie, separace

  • 1997 - 2000
    • •
  • 29 817 tis. Kč
    • •
  • 19 720 tis. Kč
    • •
  • MŠMT
Project

Atomically resolved in vivo NMR spectroscopy as a novel tool for biological testing of therapeutically important genomic non-canonical DNA targets and their interactions with drugs in phenotypically (NV19-08-00450)

-cancer drugs. Currently established procedures for the identification of DNA targets and development of DNA-binding ligands/drugs are either based on data that abstracts fromNon-canonical DNA structures i...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 13 449 tis. Kč
    • •
  • 13 449 tis. Kč
    • •
  • MZ
Project

Recognizing DNA damage by Tumor Suppressor Proteins. Effects of Anti - Cancer Drugs. (NC7574)

Using mainly electrophoretic and immunochemical methods, interactions of protein p53 (and its homologues) with damaged DNA will be studied. Our efforts will be focused mainly on the effects of anticancer drugs. We will stud...

FC - Pneumologie

  • 2003 - 2005
    • •
  • 2 921 tis. Kč
    • •
  • 2 004 tis. Kč
    • •
  • MZ
Project

Spatial structure of Ag(I) complexes the relation to antimicrobial activity (GPP205/12/P584)

of their interactions with components of microbial cells on the molecular level using of antibiotic actions will be tested: the inactivation of the cell proteins or the inhibition of DNA transcription. This information wil...

BO - Biofyzika

  • 2012 - 2014
    • •
  • 1 293 tis. Kč
    • •
  • 1 293 tis. Kč
    • •
  • GA ČR
Project

Analysis of the interactions of mutagens, carcinogens and anti-cancer drugs with biopolymers by means of electrochemical and biochemical methods. (IAA4004901)

with mercury abd solid electrodes in studies of covalent and/or non-covalent interactions carcinogens, mutagens or anti-cancer drugs. 1. Electroactive covalent adducts of biomacromolecules with these substances will be electrochemi...

CE - Biochemie

  • 1999 - 2001
    • •
  • 2 422 tis. Kč
    • •
  • 827 tis. Kč
    • •
  • AV ČR
Project

The presentation of the results of the study of secondary metabolite production in actinomycetes. (PG99141)

and genetics of production of lincomycine, the important antibiotic drug, commonly used and a specific role of different forms of DNA dependent RNA polymerase during the cell......

EE - Mikrobiologie, virologie

  • 1999 - 1999
    • •
  • 135 tis. Kč
    • •
  • 67 tis. Kč
    • •
  • MŠMT
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

Interactions of tumor suppressor protein p53 with DNA are crucial for its and mut p53 interactions with damaged DNA, particularly DNA treated with antitumor and molecular-biologicaltechniques, interact...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Project

Development and implementation of tools for digitization of healthcare (FX03030134)

of ​​control over prescribed drugs (but also vaccines and their mutual interaction), control and prescribed antibiotics. It is also about planning and control over, which will have the main task of performing drug...

Computer hardware and architecture

  • 2021 - 2023
    • •
  • 6 331 tis. Kč
    • •
  • 3 159 tis. Kč
    • •
  • MPO
Project

Interactions of organometallic antitumor compounds with nucleic acids and proteins study of sequence and substrate selectivity (GAP208/12/0622)

of DNA structure and changes of its interactions with proteins. We will focus changes in the secondary structure of DNA during the drug coordination, influence of the complex binding on the base-pair interacti...

CF - Fyzikální chemie a teoretická chemie

  • 2012 - 2015
    • •
  • 5 435 tis. Kč
    • •
  • 5 435 tis. Kč
    • •
  • GA ČR
Project

Electrochemistry polynucleotides, synthetic oligonucleotides and some substances interacting with nucleic acids. (IAA4004601)

of the polynucleotides interactions with drugs and other substances requiring the reductive activation for its specific interaction with DNA. and interfacial properties of DNA and RNA on one hand and thei...

CF - Fyzikální chemie a teoretická chemie

  • 1996 - 1998
    • •
  • 1 135 tis. Kč
    • •
  • 762 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 7 515