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4 602 (0,159s) •

Project

Virus sensing and interferon signaling in avian cells (GA23-07210S)

Sensing of viruses and mounting of rapid innate immune response depends on multiple cellular pathways. Key part in this process is played by RIG-I-like receptors (RLR) and by induction of interferons (IFN) by interferon regulato...

Genetics and heredity (medical genetics to be 3)

  • 2023 - 2025
    • •
  • 8 083 tis. Kč
    • •
  • 8 083 tis. Kč
    • •
  • GA ČR
Project

Interferon regulatory factors in insects (GA204/99/1336)

is mediatedvia a DNA element strikingly similar to the binding sites of vertebrate interferon regulatory factors (IRF). We speculate that the homologues of IRF proteins are involved: (i) practically all major classes of tr...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 603 tis. Kč
    • •
  • 603 tis. Kč
    • •
  • GA ČR
Project

Role of the host-dependent factors in prediction of antiviral treatment response in chronic hepatitis C (NT11235)

We shall validate the significance of the polymorphism -764G/C in the interferon gamma gene promoter and polymorphisms in IL28B gene in prediction of treatment treatment of chronic hepatitis C, we shall asses the expression of the interf...

FE - Ostatní obory vnitřního lékařství

  • 2010 - 2015
    • •
  • 5 558 tis. Kč
    • •
  • 5 522 tis. Kč
    • •
  • MZ
Project

The development of lower urinary tract dysfunction in remittent form of multiple sclerosis on dependency of neurological treatment. (NR8188)

The prospective study of development of lower urinary tract dysfunction in patients treated by drugs of the first choice for remittent stadium of multiple sclerosis (interferons) and the patients treated by combine immunosuppressives.......

FH - Neurologie, neurochirurgie, neurovědy

  • 2004 - 2006
    • •
  • 1 999 tis. Kč
    • •
  • 1 569 tis. Kč
    • •
  • MZ
Project

Control of stress and interferon regulated gene expression by transcription factors, histone modification and nuclear compartmentalization (GEDYN/04/E002)

Interferon and cellular stresses are well established factors known to stimulate gene transcription. Their impact is mediated by distinct signalling pathways including a cascade of effector protein kinases. P38, an isoform of stress...

EA - Morfologické obory a cytologie

  • 2005 - 2007
    • •
  • 4 713 tis. Kč
    • •
  • 4 713 tis. Kč
    • •
  • GA ČR
Project

Identification of new prognostic factors and markers of activity in multiple myeloma. Efficacy of new therapeutical approaches. (IZ3170)

FD - Onkologie a hematologie

  • 1995 - 1997
    • •
  • 886 tis. Kč
    • •
  • 848 tis. Kč
    • •
  • MZ
Project

Immunohistochemical detection of predictive factors of response to interferon therapy in patients with chronic hepatitis C (NR7814)

Hepatitis C virus (HCV) related alteration of signalling pathways and proteins (Jak-Stat, ERK1/2, NF-kB, MAP, etc.) regulated/activated by interferon (IFN) may lead to resistance to IFN treatment of patients with HCV infection. HCV infection...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 1 733 tis. Kč
    • •
  • 1 618 tis. Kč
    • •
  • MZ
Project

Construction of a model of regulatory network controlled by sigma factors of RNA polymerase in Corynebacterium glutamicum (GA17-06991S)

regulatory network. To analyze regulons controlled by particular sigma factors (sigmulons results will be integrated in a model of sigma factor regulatory network in C. Corynebacterium glutamicum genome encodes th...

EE - Mikrobiologie, virologie

  • 2017 - 2021
    • •
  • 5 013 tis. Kč
    • •
  • 4 932 tis. Kč
    • •
  • GA ČR
Project

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

The role of plasmacytoid dendritic cells (pDCs), the major source of type I interferon (IFN-I) in human organism, in pathogenesis of HIV-1 infection is not clear. In contrast to HIV-1 infected lymphocytes, HIV-1 virions are weak inducers of ...

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Project

N antigen SARS-CoV-2 in the peripheral blood and risk factors of COVID-19 progression to severe clinical status (NU22-E-109)

Aim of our study is to assess the detection and quantity of anti SARS-CoV-2 antibodies in IgM, IgG and IgA classe against nucleocapsid protein (N protein) and Spike protein, same as antibodies against interferon as possible risk factor

Virology

  • 2022 - 2023
    • •
  • 1 873 tis. Kč
    • •
  • 1 873 tis. Kč
    • •
  • MZ
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