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71 (0,057s) •

Project

Use of interferon in the treatment of viral infections. (IZ2098)

9F - 9

  • 1994 - 1996
    • •
  • 560 tis. Kč
    • •
  • 810 tis. Kč
    • •
  • MZ
Project

Dependence of sustained virological response on the early viral kinetics in the treatment of chronic hepatitis C patients with combination of alpha-interferon, or pegylated interferon, and ribavirin. (NI7484)

We shall make a detection of serum HCV RNA levels in chronic hepatitis C patients treated by combination of alpha-interferon, or pegylated interferon, and ribavirin by polymerase chain reaction. We shall do this evaluation before tr...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
    • •
  • 1 287 tis. Kč
    • •
  • 1 245 tis. Kč
    • •
  • MZ
Project

Treatment by interferon alpha 2a of thrombocytopenic (ITP) purpura in children caused by the immunity defect. (IZ3710)

FG - Pediatrie

  • 1996 - 1997
    • •
  • 547 tis. Kč
    • •
  • 530 tis. Kč
    • •
  • MZ
Project

Role of the host-dependent factors in prediction of antiviral treatment response in chronic hepatitis C (NT11235)

We shall validate the significance of the polymorphism -764G/C in the interferon gamma gene promoter and polymorphisms in IL28B gene in prediction of treatment treatment of chronic hepatitis C, we shall asses the expression of the interf...

FE - Ostatní obory vnitřního lékařství

  • 2010 - 2015
    • •
  • 5 558 tis. Kč
    • •
  • 5 522 tis. Kč
    • •
  • MZ
Project

Lymphokine induced differentiation of human leukemic cells. (IZ1917)

9F - 9

  • 1994 - 1996
    • •
  • 1 499 tis. Kč
    • •
  • 1 999 tis. Kč
    • •
  • MZ
Project

The study of molecular defects of cancer cell in the transduction pathways of interferon signals mediated by STAT 1/SOCS 3 proteins and their significance for the prediction of tumor sensitivity (NC7139)

Project intends to explore whether and to what extend cancer-related impaired interferon transduction pathways ensured by STAT 1 and SOCS 3 protein functions, MTT and morphological assays, and correlated with the interferon biologic...

EC - Imunologie

  • 2002 - 2004
    • •
  • 6 107 tis. Kč
    • •
  • 6 059 tis. Kč
    • •
  • MZ
Project

The role of selected chemokine receptors and interferone-beta in the pathogenesis of rheumatoid arthritis (NI6459)

Identification of the role for CXCR3 and CCR5 and their ligands in the synovial tissue of patients with early rheumatoid arthritis. Exploration of the role of interferon beta in the synovial inflammation and assessment of its suppresive effe...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2001 - 2003
    • •
  • 3 146 tis. Kč
    • •
  • 3 120 tis. Kč
    • •
  • MZ
Project

DONOR-SPECIFIC INTERFERON-GAMMA PRODUCING CELLS AND PREDICTION OF REJECTION OF THE KIDNEY ALLOGRAFT (NT14022)

We are aiming to study the clinical significance of Interferon-gamma producing cells as detected by the ELISpot method with the goal to assess the risk of development of cellular and antibody-mediated transplant rejection and consequently to...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2013 - 2015
    • •
  • 4 647 tis. Kč
    • •
  • 4 334 tis. Kč
    • •
  • MZ
Project

Pharmacogenomics - a promising way for reasonable and efficacious multiple sclerosis treatment (1A8713)

Observation of seleted genes expression in patients with the first attack of neurological symptomatology suspected of multiple sclerosis development before and after the initiation of interferon beta treatment. Efficacy of interferon

EB - Genetika a molekulární biologie

  • 2005 - 2010
    • •
  • 7 909 tis. Kč
    • •
  • 7 789 tis. Kč
    • •
  • MZ
Project

Virus sensing and interferon signaling in avian cells (GA23-07210S)

Sensing of viruses and mounting of rapid innate immune response depends on multiple cellular pathways. Key part in this process is played by RIG-I-like receptors (RLR) and by induction of interferons (IFN) by interferon regulatory f...

Genetics and heredity (medical genetics to be 3)

  • 2023 - 2025
    • •
  • 8 083 tis. Kč
    • •
  • 8 083 tis. Kč
    • •
  • GA ČR
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