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670 (0,155s) •

Project

Pushing the limits of the cellular plasticity in the intestinal epithelium by altering the cellular fates of differentiated cells (GA25-17207S)

relevance to colon cancer and intestinal regeneration.The cellular plasticity connected to re-activated embryonic gene expression allows the intestinal epithelial cells to face epithelial damage. On the other hand molecula...

Cell biology

  • 2025 - 2027
    • •
  • 11 806 tis. Kč
    • •
  • 11 806 tis. Kč
    • •
  • GA ČR
Project

Transformations of the gastrointestinal stem cell niche during the development and regeneration (GA21-26025S)

of colon cancer and intestinal regeneration. Additionally, intestinal epithelial stem the transformation of the embryonic intestinal epithelial stem cells to adult ones at the level of the intestinal stem...

Cell biology

  • 2021 - 2023
    • •
  • 8 487 tis. Kč
    • •
  • 8 487 tis. Kč
    • •
  • GA ČR
Project

The canonical Wnt pathway components involved in non-canonical signaling mechanisms (GA18-26324S)

in the adult colon, colon cancer, and intestinal regeneration will be characterized using transgenic mouse models, intestinal organoid cultures, and xenografts. The results will be employed to identify the composition of L...

Cell biology

  • 2018 - 2022
    • •
  • 9 615 tis. Kč
    • •
  • 8 721 tis. Kč
    • •
  • GA ČR
Project

Wnt ligands and Wnt-secreting cells for intestinal homeostasis, regeneration and colon cancer a complex world beyond the cancer-activating mutation (GA18-21466S)

of most abundant, but also most enigmatic ligand Wnt5a for intestinal renewal, regeneration. We expect that successful accomplishment of the research objectives......

Developmental biology

  • 2018 - 2022
    • •
  • 8 406 tis. Kč
    • •
  • 7 632 tis. Kč
    • •
  • GA ČR
Project

Intestinal microflora in infants at risk of an earlier development of allergic diseases. (NR8310)

Composition of intestinal microflora in healthy newborns and fully breast-fed infants in comparison to composition of intestinal microflora in fully breast-fed with atopic eczema. Investigation of composition of intestinal ...

FG - Pediatrie

  • 2005 - 2009
    • •
  • 5 047 tis. Kč
    • •
  • 4 893 tis. Kč
    • •
  • MZ
Project

Cytokine regulations of intestinal epithelial cell functions (1P05ME783)

study of cytokine impact on gene expression of enzymes of intestinal cells...

ED - Fyziologie

  • 2005 - 2008
    • •
  • 1 516 tis. Kč
    • •
  • 1 053 tis. Kč
    • •
  • MŠMT
Project

EXIT & SIT; EX VIVO TISSUE MODELS FOR SMALL INTESTINE TISSUE (GA25-17718S)

construction for ex vivo reconstituted intestinal tissues is relatively undeveloped, biological, and structural properties of the individual layers of small intestinal tissue and physical characteristics found in intestinal

Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

  • 2025 - 2027
    • •
  • 11 052 tis. Kč
    • •
  • 11 052 tis. Kč
    • •
  • GA ČR
Project

Ruminally protected protein and its intestinal digestibility (GA523/02/0164)

In cattle intestine, digestible amino acids are supplied either feed protein the absorption of amino acids in small intestine of dairy cows, degradability of feed protein be better utilised in the intestine. In dry dairy co...

GH - Výživa hospodářských zvířat

  • 2002 - 2004
    • •
  • 4 106 tis. Kč
    • •
  • 3 896 tis. Kč
    • •
  • GA ČR
Project

Immunological and physiological characteristics of the intestine in probiotic associated animals. Experimentally induced enterocolitis (IAA5020101)

in the intestine of monoassociated and germfree animals. The immunological study will concern membranemarkers of intestinal lymphocytes which will be detected using flow cytometry information on intestinal brush border mem...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2001 - 2004
    • •
  • 4 684 tis. Kč
    • •
  • 2 612 tis. Kč
    • •
  • AV ČR
Project

Mechanisms of gut function modulation by nutritional hyaluronan (GA25-16326S)

the efficacy of nutritionally supplied HA in the treatment of chronic intestinal and unsaturated HA oligosaccharides on chronic intestinal inflammation using an established in the inflamed intestine after p.o. HA applicati...

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 8 019 tis. Kč
    • •
  • 8 019 tis. Kč
    • •
  • GA ČR
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