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4 068 (0,158s) •

Project

Intracellular and extracellular targets for antitumor activity and toxicity of ruthenium complexex (1P05OC070)

complexex of rhutenium as a new class of promising cytostatics effective in tumor cell resistant to platinum cytostatics...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2006
    • •
  • 705 tis. Kč
    • •
  • 522 tis. Kč
    • •
  • MŠMT
Project

Intracellular and extracellular targets for antitumor of ruthenium complexes (OC D20.003)

of the extracellular matrix. Third, we want to ascertain the existence of a cell membraner, eceptor and a biological target for the selective treatment of solid tumour metasta, ses by interfering......

CE - Biochemie

  • 2002 - 2005
    • •
  • 3 265 tis. Kč
    • •
  • 1 326 tis. Kč
    • •
  • MŠMT
Project

Membráne properties of astrocytes and the role of extracellular matrix molecules during astrogliosis in the CNS (GA305/02/1528)

by the properties of the extracellular space. The effect of extracellular matrix molecules and intracellular filaments on ionic channels in glial cells have not yet been studied in detail lacking tenascin C or tenascin R, ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2004
    • •
  • 3 472 tis. Kč
    • •
  • 2 932 tis. Kč
    • •
  • GA ČR
Project

Calcium signaling in neonatal rat gonadotrophs (IAA5011105)

and extracellular Ca2+ dependence of refilling of intracellular calcium stores.Intracellular calcium plays an important role in regulation of many cellular inositol 1,4,5-trisphosphate-sensitive intracellular stor...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 2 917 tis. Kč
    • •
  • 848 tis. Kč
    • •
  • AV ČR
Project

Proteomic analysis Francisella tularensis LVS cultivated intracellular in vitro and in vivo, identification of potential virulence factors (GP310/06/P266)

Infections caused by intracellular bacteria represent a real threat due to the insufficient understanding of molecular mechanisms of pathogeneses. For example Francisella of differential expressed proteins of intracellular cultivate...

EE - Mikrobiologie, virologie

  • 2006 - 2008
    • •
  • 1 180 tis. Kč
    • •
  • 1 180 tis. Kč
    • •
  • GA ČR
Project

Muscle remodelling on the basis of extracellular matrix seeded with functionally characterized cells. (GA15-09161S)

For the first time, we propose a novel approach to muscle organ reconstruction based on colonization of decellularized extracellular matrix (ECM) isolated from the skeletal muscle with muscle-derived cells. Simultaneously, the physiopatholog...

ED - Fyziologie

  • 2015 - 2019
    • •
  • 5 955 tis. Kč
    • •
  • 5 955 tis. Kč
    • •
  • GA ČR
Project

Study of molecular mechanisms causing v-Myb suppression using proteomics-based approach (GA301/03/1055)

transcription factor that changes expression pattern of its target genes and/or interacts and/or apoptosis in response to extracellular stimuli such as phorbol esters (TPA interactions of v-Myb protein and/or its target ge...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 3 327 tis. Kč
    • •
  • 3 327 tis. Kč
    • •
  • GA ČR
Project

Role of mTORC1 signalling in intracellular processing and trafficking of Alzheimer’s disease-associated amyloid precursor protein and its derivatives (GJ19-08304Y)

Alzheimer’s disease (AD) is the most frequent neurodegenerative disease and might result in personality changes. Deposition of extracellular amyloid (Aβ) plaques is the main molecular symptom of AD, where Aβ is a product of the intracell...

Biochemistry and molecular biology

  • 2019 - 2020
    • •
  • 5 206 tis. Kč
    • •
  • 5 206 tis. Kč
    • •
  • GA ČR
Project

Genetically-engineered extracellular vesicles as novel imaging and therapeutical probes for specific targeting of tumors (GN22-13334I)

site is highly desirable. Extracellular vesicles (EVs) as natural nanoparticles targeted to specific biomarkers serving as an ideal drug delivery vehicle. Here, we targeted to overexpressed tumor receptors and acidic tumor...

Health-related biotechnology

  • 2022 - 2025
    • •
  • 5 350 tis. Kč
    • •
  • 5 350 tis. Kč
    • •
  • GA ČR
Project

Receptor-mediated drug targeting info human colorectal cancer (NC5050)

1)To study the role of ligand in receptor-mediated endocytosis of targeted polymeric produgs used for the treatnebt of human colorectal cancer. 2)To determine the intracellular trafficking and processing of targeted polymer...

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 5 743 tis. Kč
    • •
  • 5 023 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 4 068