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154 (0,112s) •

Project

Structural and biophysical basis of the reaction mechanism of intramembrane proteolysis (GA18-09556S)

Intramembrane proteases (IMPRs) regulate a number of biological processes and are implicated in human diseases. In contrast to their importance and ubiquity, they are only poorly understood mechanistically. Crystal structures of rep...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 8 212 tis. Kč
    • •
  • 6 973 tis. Kč
    • •
  • GA ČR
Project

Roles of the rhomboid intramembrane protease RHBDL2 in lung epithelial homeostasis and pathology of idiopathic pulmonary fibrosis (GA21-24456S)

Epithelia form essential protective barriers facing constant stress and injury. Their aberrant renewal and healing with excessive scarring can lead to the loss of organ function and the development of fibrotic pathologies. We found that mice deficien...

Cell biology

  • 2021 - 2023
    • •
  • 9 840 tis. Kč
    • •
  • 9 345 tis. Kč
    • •
  • GA ČR
Project

Intramembrane proteases of rhomboid family – specificity, mechanism, and substrate identification as a key to their biological roles. (GAP305/11/1886)

Rhomboids are intramembrane proteases that are known to control developmental signalling, mitochondrial dynamics and pathogenicity of the malaria parasite. Although widely conserved in evolution, their functions in most organisms in...

CE - Biochemie

  • 2011 - 2015
    • •
  • 3 819 tis. Kč
    • •
  • 3 819 tis. Kč
    • •
  • GA ČR
Project

Intramembrane proteases of the rhomboid family in the secretory pathway of mammalian cells substrate repertoire, specificity, biological roles and their inhibition (LK11206)

Rhomboids are intramembrane proteases highly conserved in evolution. In insects, they mediate secretion of bioactive forms of growth factors, thus regulating developmental signaling, while their fuctions within the secretory pathway...

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 20 171 tis. Kč
    • •
  • 20 171 tis. Kč
    • •
  • MŠMT
Project

Cellular and organismal roles of the intramembrane rhomboid protease RHBDL4 (GA20-25331S)

Rhomboid intramembrane proteases regulate epidermal growth factor receptor signalling in Drosophila, but their main functions in mice and humans are probably different and remain poorly understood. The endoplasmic reticulum (ER) loc...

Cell biology

  • 2020 - 2022
    • •
  • 9 570 tis. Kč
    • •
  • 9 390 tis. Kč
    • •
  • GA ČR
Project

Specification of osteogenic potential of caspases in context of craniofacial development (GA19-14727S)

Craniofacial development includes intramembranous osteogenesis, where osteoblasts differentiate from mesenchymal precursors. Caspases are known to contribute to inflammation and cell death, however, recent evidence points to much broader spe...

Developmental biology

  • 2019 - 2022
    • •
  • 8 009 tis. Kč
    • •
  • 7 742 tis. Kč
    • •
  • GA ČR
Project

Novel functions of c-Myb during intramembranous bone formation analyzing molecular interactions in craniofacial morphogenesis (GJ19-15272Y)

in osteogenesis especially in the intramembranous type of ossification. First, the molecular...

Developmental biology

  • 2019 - 2023
    • •
  • 4 720 tis. Kč
    • •
  • 4 720 tis. Kč
    • •
  • GA ČR
Project

Digestive enzymes of Schistosoma_ New target for the treatment of parasitic (KJB400550516)

proteases critical for metabolism of Schistosoma. The selected proteases. The activation process will be analyzed for the protease zymogens processed to the mature for interactionwith the active site of the protease

CE - Biochemie

  • 2005 - 2007
    • •
  • 888 tis. Kč
    • •
  • 888 tis. Kč
    • •
  • AV ČR
Project

Detection and characterisation of HIV-1 mutants resistant to specific therapy with protease inhibitors evolution of the resistant species and their interactions with other viral proteins (NI6339)

Resistant HIV strains in patients treated by protease inhibitors. Sequencing, cloning and analysis of recombinant mutant proteases. Design of a broad specificity inhibitor. Co-evolution of protease and pther viral genes in ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2000 - 2002
    • •
  • 4 431 tis. Kč
    • •
  • 3 170 tis. Kč
    • •
  • MZ
Project

Molecular mechanism of function of proteases in breast cancer (1P04OCB20.002)

The project is on structure-function relationship in cathepsin D protease playing a critical role in breast cancer....

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 400 tis. Kč
    • •
  • 1 800 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 154