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1 004 (0,064s) •

Project

The induction of antiviral immune response after intranasal aplicaton of nanoparticles based vaccine (LTAUSA19003)

The aim of this study is to develop of chitosan-nanoparticles based vaccine against cytomegalovirus for intranasal application and investigation of the immune response on model animals (mice and nonhuman primates) after application ...

Cell biology

  • 2020 - 2022
    • •
  • 3 012 tis. Kč
    • •
  • 3 012 tis. Kč
    • •
  • MŠMT
Project

Intranasal vaccination in prevention of autoimmune diseases (NS10340)

Mechanisms of induction of mucosal protective immunity by intranasal administration of autoantigens using bioptic material of human nasal mucosa and mouse models of type 1. diabetes and ulcerative colitis. Role of NALT (Nasal associ...

EC - Imunologie

  • 2009 - 2011
    • •
  • 2 561 tis. Kč
    • •
  • 2 561 tis. Kč
    • •
  • MZ
Project

Systemic and mucosal immune response after adjuvant mucosal immunization with inactivated influenza virus (GA310/02/0467)

, will be exploited in mucosal immunization by inactivated influenza virus and its subunits. Mice, guinea pigs and ferrets will be immunized via respiratory tract (intranasal andintrapulmonal immunization) with fol...

EC - Imunologie

  • 2002 - 2004
    • •
  • 2 907 tis. Kč
    • •
  • 2 907 tis. Kč
    • •
  • GA ČR
Project

Extracellular vesicles produced by Bifidobacterium as novel approach for treatment of allergy diseases (GF23-04050L)

Probiotics have immunomodulatory properties positively affecting immune system and health balance. Despite the general assumption that the use of probiotics is safe have not been documented especially in intranasal administration an...

Microbiology

  • 2023 - 2025
    • •
  • 5 253 tis. Kč
    • •
  • 5 253 tis. Kč
    • •
  • GA ČR
Project

Development of the effective drug delivery system intended for application in organophosphate poisoning for intranasal administration (FW09020121)

of a prototype intranasal formulation as an alternative to current therapeutics and anticonvulsant) intranasally • to determinate biodistribution, pharmacokinetics and drug......

Pharmacology and pharmacy

  • 2023 - 2027
    • •
  • 11 780 tis. Kč
    • •
  • 7 643 tis. Kč
    • •
  • TA ČR
Project

PAIN - new pain treatment possibilities of injured people in battlefield (OFUVN20150001)

Research of a new therapeutic form and new application device needs several steps. First, an appropriate drug for the nasal administration must be found, optimal dose assessed in an animal experiment, followed by clinical testing. The primary aim of ...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2016
    • •
  • 1 897 tis. Kč
    • •
  • 1 897 tis. Kč
    • •
  • MO
Project

Immune mechanisms of gliadin/gluten in pathogenesis and prevention of type 1 diabetes two immuno-preventive strategies for translation to humans. (GA15-24487S)

of regulatory immune mechanisms and test regulatory capacity of cell subsets potentially...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2018
    • •
  • 5 277 tis. Kč
    • •
  • 5 277 tis. Kč
    • •
  • GA ČR
Project

Needle Free Treatment for Anaphylaxis (TQ08000002)

The goal of the project is the development of a prototype intranasal formulation containing a pharmaceutical active substance, applied to the nasal mucosa, which ensures a sufficient plasma concentration of epinephrine for the non-invasive p...

Pharmacology and pharmacy

  • 2023 - 2025
    • •
  • 26 221 tis. Kč
    • •
  • 18 354 tis. Kč
    • •
  • TA ČR
Project

E. COLI O83 IN THE PREVENTION OF THE POLY-SENSITIZATION IN CONVENTIONAL AND GNOTOBIOTIC MOUSE MODEL OF POLLEN ALLERGY (8J20AT011)

imaging (A) Aim 3: Intranasal application of WT-E. coli O83 and CBRluc-E. coli O83 with help of A) Aim 5: Intranasal application of WT-E. coli O83 to conventional mice......

Microbiology

  • 2020 - 2022
    • •
  • 156 tis. Kč
    • •
  • 156 tis. Kč
    • •
  • MŠMT
Project

Formulation of atropine into modern noninvasive delivery systems (NW25-08-00401)

systems for non-invasive intranasal application of atropine to be used in the civilian...

Pharmacology and pharmacy

  • 2025 - 2028
    • •
  • 11 397 tis. Kč
    • •
  • 11 288 tis. Kč
    • •
  • MZ
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