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504 (0,107s) •

Project

In vitro and in vivo function of isolated animal and human pancreatic iskets and the possibility of its modification in allogenic transplantation (ND6362)

pancreatic islet isolation and the study of potential induction of immunologic islet tolerance with bone marrow co-transplantation. Islet function will be tested method might be used for clinical application of

FJ - Chirurgie včetně transplantologie

  • 2000 - 2002
    • •
  • 3 029 tis. Kč
    • •
  • 2 914 tis. Kč
    • •
  • MZ
Project

Optimalization of the culture conditions of the isolated Langerhans islets for transplantation (NT13099)

We will test new methods of protection and cultivation of isolated pancreatic islets designed for transplant therapy of diabetes using the following modifications inhibitors and the use of mesenchymal stem cells conditioned medium f...

FJ - Chirurgie včetně transplantologie

  • 2012 - 2015
    • •
  • 7 019 tis. Kč
    • •
  • 6 936 tis. Kč
    • •
  • MZ
Project

Metabolic control and diabetes complications in clinical islet transplantation a pilot study (NT14020)

Pancreatic islet transplantation today represents a real treatment option, if it is possible using islet transplantation to achieve a composite end-point consisting or those who are listed for simultaneous kidney <...

FJ - Chirurgie včetně transplantologie

  • 2013 - 2015
    • •
  • 3 709 tis. Kč
    • •
  • 3 709 tis. Kč
    • •
  • MZ
Project

Epigenetic intervention as a tool improving the outcomes of pancreatic islet transplantation (GA14-03305S)

The transplantation of pancreatic islets is a clinically relevant therapeutic) as a promising tool for better islet preservation during its isolation and transplantation-transplant hyper coagulation and no...

FJ - Chirurgie včetně transplantologie

  • 2014 - 2018
    • •
  • 5 475 tis. Kč
    • •
  • 5 475 tis. Kč
    • •
  • GA ČR
Project

Evaluation of new transplant sites for pancreatic islets using non-invasive imaging methods in animal models. (NU22-08-00286)

This project aims to evaluate the survival and function of transplanted islets of Langerhans in new transplant sites that need to be considered for use in human medicine. These are transplants into the greater omen...

Medicinal chemistry

  • 2022 - 2025
    • •
  • 12 476 tis. Kč
    • •
  • 12 476 tis. Kč
    • •
  • MZ
Project

High precision quantification of rodent and human pancreatic islets for transplantation (NU22-01-00141)

Clinical outcome of pancreatic islet transplantation depends on the number of functional beta-cells in the graft. The current methods for islet graft assessment in the graft. Moreover, the necrotic core which develops in

Transplantation

  • 2022 - 2025
    • •
  • 11 544 tis. Kč
    • •
  • 11 544 tis. Kč
    • •
  • MZ
Project

Experimental transplantation of porcine, canine and human pancreatic islets (GA308/96/1514)

Transplantation of isolated pancreatic islets (PI) is one of the most complications.A prereguisite of a successful transplantation is to collect a sufficient amount of viable pure islets, to ensure their short-term...

FR - Farmakologie a lékárnická chemie

  • 1996 - 1998
    • •
  • 4 365 tis. Kč
    • •
  • 4 019 tis. Kč
    • •
  • GA ČR
Project

Automatic analysis of microscopy images of Langerhans islets (GA14-10440S)

Transplantation of isolated islets of Langerhans is an experimental treatment evaluation of the quantity and shape of the isolated islets, in order to assess the transplant viability. Various simple computerized me...

JD - Využití počítačů, robotika a její aplikace

  • 2014 - 2018
    • •
  • 3 865 tis. Kč
    • •
  • 3 865 tis. Kč
    • •
  • GA ČR
Project

Posttransplant function of ischemically impaired organs (pancreas, kidney, islets) preserved by oxygenated perfluorocarbon (PFC). (NR9383)

The aim of this project is to improve the function of transplanted ischemically impaired organs (kidney, pancreas, islets) by storage in oxygenated perfluorocarbon in a rat model using so called two-layer method for cold storage.......

FJ - Chirurgie včetně transplantologie

  • 2007 - 2009
    • •
  • 3 306 tis. Kč
    • •
  • 3 289 tis. Kč
    • •
  • MZ
Project

The use of pancreatic islet extracellular matrix for propagation and controlled differentiation of insulin producing cells (GA19-07661S)

Pancreatic islet transplantation into the liver represents an established conditions at the transplant site and lack of organ donors. In the proposed project, we plan to use the native extracellular pancreatic or single

Endocrinology and metabolism (including diabetes, hormones)

  • 2019 - 2022
    • •
  • 9 458 tis. Kč
    • •
  • 9 458 tis. Kč
    • •
  • GA ČR
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