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13 (0,079s) •

Project

New Methods for Determination of Neuroactive Steroids and Their Polar Conjugates in Human Tissues and Serum (NR7768)

We intend to develop new high sensitive and selective methods for determination of neuroactive pregnanolone isomers by means of gass chromatgraphy with mass spectrometry (GC-MS) with new derivatization techniques. The new quick and sensitive...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 4 691 tis. Kč
    • •
  • 4 194 tis. Kč
    • •
  • MZ
Project

Haptens for immunoassays of neuroactive steroids of pregnanolone type (GA203/04/0123)

Natural pregnanolone derivatives with hydroxyl group in position 3 and ketone,5beta(pregnanolone) have function both in the central nervous system and periphery pregnanolone stereoisomers or their conjugates can affect the ...

CC - Organická chemie

  • 2004 - 2005
    • •
  • 1 051 tis. Kč
    • •
  • 1 051 tis. Kč
    • •
  • GA ČR
Project

Neuroactive steroids in male reproduction (1A8235)

The aim of the project is the study of the participation of neuroactive steroids (pregnenolone and isomers of pregnanolone) in the course of the male orgasm and ejaculation as a basis of potential treatment of their disturbances.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 1 331 tis. Kč
    • •
  • 1 287 tis. Kč
    • •
  • MZ
Project

Neuroendocrine and neurophysiological changes in patients after brain injury. (IZ4207)

We will follow the levels of LH, FSH, PRL, E2, testosterone, dihydrotestosterone, cortisol, TSH, fT4, progesterone and its brain metabolite, pregnanolone and its relationship to brainedema evolution in patients after brain contusion. We will...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1997 - 1999
    • •
  • 1 787 tis. Kč
    • •
  • 1 461 tis. Kč
    • •
  • MZ
Project

20alpha-hydroxy-metabolites of neuroactive pregnenolone isomers, progesterone and pregnenolone around parturition and the importace in physiology and diagnostics (NR9156)

The project investigates a possibility of influencing of the onset of parturition by changes in activity of 20alfa-hydroxysteroid dehydrogenase, which could contribute to the accelerating catabolism of progesterone and neuroinhibiting pregnanolon...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 7 161 tis. Kč
    • •
  • 5 883 tis. Kč
    • •
  • MZ
Project

Changes in the profile of steroids and their neuroactive metabolites in relation to prediction of term (NS9834)

, 5beta- and 3alpha- isomers of pregnanolone in human. The obtained information...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 5 646 tis. Kč
    • •
  • 5 646 tis. Kč
    • •
  • MZ
Project

Biological activity and pharmacokinetic properties of 3?C substituted derivatives of pregnanolone (NS10365)

effects. Previous results demonstrated that naturally occurring 3?5ß-pregnanolone...

FR - Farmakologie a lékárnická chemie

  • 2009 - 2011
    • •
  • 4 931 tis. Kč
    • •
  • 4 834 tis. Kč
    • •
  • MZ
Project

The role of neuroactive steroids in the disorders of nervous system (NB6691)

The method of determination of pregnanolones and their conjugates will be developed. The levels of steroid modulators of GABA and NMDA receptors will be evaluated in controls, epileptic women during menstrual cycle and in patients with Alzhe...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 3 946 tis. Kč
    • •
  • 3 320 tis. Kč
    • •
  • MZ
Project

Kinetics of the percutaneous penetration of optical isomers in sunscreens, brominated flame retardants and polar pesticides in dermal exposure (GA14-27941S)

Knowledge of the transport kinetics of harmful chemicals through biological barriers is essential for human exposure assessment. There are still important gaps in scientific data on the experimental kinetics and skin transfer coefficients of some che...

DN - Vliv životního prostředí na zdraví

  • 2014 - 2016
    • •
  • 4 971 tis. Kč
    • •
  • 4 971 tis. Kč
    • •
  • GA ČR
Project

Anti-inflammatory properties of neuroactive steroids (NW25J-04-00127)

synthetic neuroactive steroids, pregnanolone glutamate and pregnanolone pyroglutamate...

Neurosciences (including psychophysiology)

  • 2025 - 2028
    • •
  • 6 983 tis. Kč
    • •
  • 6 983 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 13