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357 (0,075s) •

Project

Aurora kinases and their role in cell division of acentrosomal plant cells (GP204/09/P155)

The Aurora kinase family presents a serine/threonine protein kinases organization machinery. The Aurora kinases as a crutial players in cell proliferation Aurora kinases have been analyzed, plant Aurora kinases...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 098 tis. Kč
    • •
  • 1 098 tis. Kč
    • •
  • GA ČR
Project

Regulatory roles of Lyn kinase in mast cell activation (IAA5052310)

, the regulation and consequences of Lyn kinase activity in resting and activated mast cells are not completely understood. In this proposal we will investigate how regulation of Lyn kinase. Mutants of Lyn kinase defective ...

EC - Imunologie

  • 2003 - 2006
    • •
  • 2 778 tis. Kč
    • •
  • 2 167 tis. Kč
    • •
  • AV ČR
Project

MEK kinase inhibitor UO126 - a new tool for modulation of the p42/44 mAP kinase activity in mammalian germ cells (GA524/00/0720)

The experiments proposed here will determine complementary role of cdc2 kinase of p42/44 mitogen-activated protein kinase (MAPK) in two important checkpoints be cultured in medium enriched with MAPK activating kinase (MEK) ...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2000 - 2002
    • •
  • 2 265 tis. Kč
    • •
  • 1 886 tis. Kč
    • •
  • GA ČR
Project

Molecular basis of the 14-3-3 protein-dependent regulation of protein kinase activity (GA19-00121S)

proteins including many disease-relevant protein kinases. However, our understanding of how the 14-3-3 proteins regulate the activity of these protein kinases is, in most of two physiologically important serine/threonine protein

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 340 tis. Kč
    • •
  • 8 034 tis. Kč
    • •
  • GA ČR
Project

Regulatory mechanism of kinase activity of protein kinase ASK1 (GA14-10061S)

in the regulation of the kinase activity of the catalytic domain of protein kinase ASK1 (Apoptosis signal-regulating kinase 1). The 14-3-3 protein binding to the catalytic this process we propose: (i) to prepare protein co...

CE - Biochemie

  • 2014 - 2016
    • •
  • 5 937 tis. Kč
    • •
  • 5 937 tis. Kč
    • •
  • GA ČR
Project

The role of Akt kinase in the regulation of G2/M cell cycle transition and in the acquisition of developmental potency of oocytes (GA523/03/0857)

. For this purpose the role of Akt kinase, an upstream regulator of p34cdc2 kinase of expression, activation and localisation of Akt kinase and downstream Wee1 kinase family willbe documented as well. Subsequently,...

ED - Fyziologie

  • 2003 - 2005
    • •
  • 2 745 tis. Kč
    • •
  • 1 860 tis. Kč
    • •
  • GA ČR
Project

Pteridine modulators of oncogenic protein kinases (GA25-16634S)

Protein kinases have been widely accepted as drug targets, but there are still may be hidden in the dark kinome, which includes less studied kinases. Importantly, many dark kinases are often differentially expressed or muta...

Medicinal chemistry

  • 2025 - 2027
    • •
  • 8 859 tis. Kč
    • •
  • 8 859 tis. Kč
    • •
  • GA ČR
Project

Regulation of primary cilia by cellular kinases (LTAUSA19030)

The main goal of the project is to understand molecular principles of interaction between selected cellular kinases and the primary cilium. We will (1) define the functional consequences of ICK-mediated phosphorylation of KIF3A and KIF3B in ...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2022
    • •
  • 7 110 tis. Kč
    • •
  • 7 110 tis. Kč
    • •
  • MŠMT
Project

- In vitro maturation system(s) for bovine and porcine oocytes. Project B - Interplay between cdks (cell division kinases) and MAP (mitogen activated protein) kinases during oocyte meiotic (ME 573)

inhibitors of protein kinases will be used to prolongate meiotic maturation and to reach an interplay between cell division kinases and MAP kinases during oocyte meiotic maturation and activation. Furthermore, the analysis...

ED - Fyziologie

  • 2002 - 2004
    • •
  • 1 731 tis. Kč
    • •
  • 1 261 tis. Kč
    • •
  • MŠMT
Project

Control of mTOR and MAPK pathways by Src tyrosine kinase activity - implication for cancer therapy by protein kinase inhibitors (NT11231)

Tyrosine kinase activity of Src is up-regulated in numerous types of human and clinical trials showed strong effect of tyrosine kinase inhibitors in cancer therapy. Our previous findings has shown that the suppression of Src kin...

FD - Onkologie a hematologie

  • 2010 - 2013
    • •
  • 3 723 tis. Kč
    • •
  • 3 723 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 357