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42 (0,065s) •

Project

The role of microbiome in the development of atopic dermatitis and food allergy in infants and toddlers (NU20-05-00038)

Atopic dermatitis (AD) is the most common chronic inflammatory skin disorder affecting up to 20% of children in industrialized countries during their first year of life. The pathogenesis of AD remains unclear, nevertheless, it has been shown that bot...

Immunology

  • 2020 - 2024
    • •
  • 12 364 tis. Kč
    • •
  • 12 364 tis. Kč
    • •
  • MZ
Project

Development of definitive skin implant based on collagen lattice and autologous cells for the treatment of burn wounds in the animal model. (IZ3093)

FJ - Chirurgie včetně transplantologie

  • 1995 - 1997
    • •
  • 380 tis. Kč
    • •
  • 380 tis. Kč
    • •
  • MZ
Project

Incidence of skin cancer in renal transplant recipients in transplant center in the Institute of Clinical and Experimental Medicine (IKEM). (NV15-26779A)

Based on the established cooperation between the Dermatovenereology Dept. 2nd Medical Faculty Charles University and Bulovka Hospital and the Department of Nephrology IKEM we propose a prospective epidemiological study with the aim to detect the inci...

FO - Dermatovenerologie

  • 2015 - 2018
    • •
  • 5 575 tis. Kč
    • •
  • 5 575 tis. Kč
    • •
  • MZ
Project

Tissue hypoxia in patients with chronic kidney disease – metabolic and hemodynamic associations (NV17-31796A)

Advanced type 2 diabetes mellitus patients and especially those with end-stage renal disease (ESRD) frequently suffer from cognitive dysfunction. Several possible mechanisms were suggested: advanced protein glycation, acid-base disturbances, brain hy...

FE - Ostatní obory vnitřního lékařství

  • 2017 - 2021
    • •
  • 7 642 tis. Kč
    • •
  • 7 619 tis. Kč
    • •
  • MZ
Project

Markers of mitochondrial dysfunction in presymptomatic and early stages of Huntington‘s disease (NU20-04-00136)

Huntington's disease (HD) is an autosomal dominant hereditary neurodegenerative disorder, manifested mainly by progressive movement disorders, behavioral changes and cognitive impairment. There is no treatment to stop or even cure the disease. The c...

Neurosciences (including psychophysiology)

  • 2020 - 2024
    • •
  • 11 878 tis. Kč
    • •
  • 11 828 tis. Kč
    • •
  • MZ
Project

Faecal bacteriotherapy for ulcerative colitis (NV16-27449A)

The etiopathogenesis of ulcerative colitis (UC) is not fully understood. One of the theories of UC pathogenesis represents a pathological response of mucosal immunity to intestinal microbiota. Potential therapeutic procedure how to affect this fact i...

FE - Ostatní obory vnitřního lékařství

  • 2016 - 2020
    • •
  • 6 517 tis. Kč
    • •
  • 6 418 tis. Kč
    • •
  • MZ
Project

Study on association between intestinal microbiome and increased risk of chronic inflammatory diseases of locomotor system, osteoporosis and rheumatoid arthritis. (NV18-05-00394)

In the early years after menopause, women have an increased risk for osteoporosis and rheumatoid arthritis. The aim of this study is to test our hypothesis that estrogen deficiency after menopause affects the gut microbiome, and that deterioration of...

General and internal medicine

  • 2018 - 2022
    • •
  • 13 802 tis. Kč
    • •
  • 13 776 tis. Kč
    • •
  • MZ
Project

Microbiome, its role in effectiveness of immunomodulatory therapy and pathogenesis of MS. (NU20-04-00077)

Microbiota influences immune system reactivity and may even influence the efficiency of immunomodulatory treatment of multiple sclerosis (MS). Here, we will study if the response to MS treatment regimes (i.e. glucocorticoids, interferon beta, cladrib...

Neurosciences (including psychophysiology)

  • 2020 - 2024
    • •
  • 13 826 tis. Kč
    • •
  • 13 770 tis. Kč
    • •
  • MZ
Project

Colobiome Tumour-adjacent microbiome and immune profile of tumour in the context of heterogeneity and aggressiveness of colorectal cancer (NV16-31966A)

Despite an enormous effort, the current molecular predictive and prognostic classifiers of colorectal cancer (CRC) are only marginally better than standard clinical risk factors. The reasons why lie in the tumour heterogeneity on one side and on inab...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 10 857 tis. Kč
    • •
  • 10 634 tis. Kč
    • •
  • MZ
Project

Variability and composition of nasopharyngeal microbiota in receiving hematopoietic stem cell transplantation (NV17-28539A)

The introduction of next-generation sequencing (NGS) has allowed research of human microbiome. As was demonstrated in studies of the vaginal or gastrointestinal microbiome representation of certain phyla play an irreplaceable role in maintaining of o...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2017 - 2020
    • •
  • 6 549 tis. Kč
    • •
  • 6 549 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 42