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52 (0,142s) •

Project

Analysis of interaction between Leishmania major and macrophages of susceptible and resistant mouse strains. (GP14-35944P)

parasites of genus Leishmania and transmitted by phlebotomine sandflies. The phenotype cellular compartment for Leishmania are macrophages. We and others have shown that macrophages of different inbred strains differ in permissiven...

EB - Genetika a molekulární biologie

  • 2014 - 2017
    • •
  • 1 380 tis. Kč
    • •
  • 1 380 tis. Kč
    • •
  • GA ČR
Project

Leishmania development in sand flies and molecular aspects of this interaction (GA206/03/0325)

Leishmania parasites are responsible for considerable human and animal is crucial for Leishmania circulation in the nature and transmission into vertebrate host. Themechanisms responsible for controlling sand fly susceptibility to <...

EG - Zoologie

  • 2003 - 2005
    • •
  • 4 855 tis. Kč
    • •
  • 2 105 tis. Kč
    • •
  • GA ČR
Project

Leishmania transmission by sand flies parasite-vector-host interaction (GA206/06/0967)

Parasites of genus Leishmania are responsible for considerable human and animal and immunomodulatory molecules and enhance the initial phase of Leishmania infection. In addition is aimed at different molecules involved in Leishm...

EG - Zoologie

  • 2006 - 2008
    • •
  • 3 098 tis. Kč
    • •
  • 3 098 tis. Kč
    • •
  • GA ČR
Project

Immunological analysis of sand fly - host - Leishmania interactions (GA206/09/0822)

Sand flies are the vectors of Leishmania parasites - and their saliva plays an important role in Leishmania infection development. Pre-exposure to sand fly bites can is to characterizethe immune response of repeatedly bitten host in...

EC - Imunologie

  • 2009 - 2011
    • •
  • 2 187 tis. Kč
    • •
  • 2 187 tis. Kč
    • •
  • GA ČR
Project

First genetic model for analysis of susceptibility to parasite Leishmania tropica potential implications for studies of human leishmaniases (GA310/08/1697)

Epidemiologic and experimental studies show that common diseases including infections are under control of multiple susceptibility genes. Leishmania tropica is an important pathogen that causes in humans cutaneous and visceral disease, but n...

EB - Genetika a molekulární biologie

  • 2008 - 2012
    • •
  • 6 654 tis. Kč
    • •
  • 6 654 tis. Kč
    • •
  • GA ČR
Project

Leishmania-sand fly interaction new approaches to answer old questions (GA21-15700S)

molecules involved in Leishmania-sand fly interaction which may serve as putative targets for developing leishmaniases control strategies. Unique Leishmania mutants and sand fly colonies will be used to elucidate the role of Le...

Zoology

  • 2021 - 2023
    • •
  • 9 864 tis. Kč
    • •
  • 9 864 tis. Kč
    • •
  • GA ČR
Project

Transmission cycles of Leishmania major in natural reservoir hosts local analyses with global implications (GA23-06299S)

Leishmaniases caused by Leishmania parasites and transmitted by sand flies understood factors influencing Leishmania transmission are: i) infectiousness hosts of Leishmania. In parallel, we propose to analyse these transmis...

Parasitology

  • 2023 - 2025
    • •
  • 9 368 tis. Kč
    • •
  • 9 368 tis. Kč
    • •
  • GA ČR
Project

Sand fly-Leishmania interaction Two types of attachment as critical steps in parasite life cycle. (GA25-15318S)

: Phlebotominae), knowledge on Leishmania-sand fly interaction is highly important for control steps within the Leishmania life cycle. Here, we propose a comprehensive study using molecules derived from both, Leishmania and...

Microbiology

  • 2025 - 2027
    • •
  • 10 186 tis. Kč
    • •
  • 10 186 tis. Kč
    • •
  • GA ČR
Project

Vývoj a pohlavní rozmnožování Leishmania donovani v různých druzích flebotomů. (GA13-07500S)

by Leishmania donovani (Kinetoplastida: Trypanosomatidae) being even fatal. The project of four sand fly species (2) genetic exchange among Leishmania parasites and for Leishmania sex within the sand fly midgut.......

EG - Zoologie

  • 2013 - 2016
    • •
  • 7 199 tis. Kč
    • •
  • 7 199 tis. Kč
    • •
  • GA ČR
Project

Functional genomics of Leishmania virulence (GA17-10656S)

differentiation stages and several Leishmania/Leptomonas species we have preselected promising for anti-Leishmania drug development and intervention and we suggest that inhibiting expression of these genes may result in reduced vir...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 7 919 tis. Kč
    • •
  • 7 589 tis. Kč
    • •
  • GA ČR
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