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400 (0,189s) •

Project

Investigating the pathologic role of metalloproteinases in liver using transgenic mice with conditional expression of transgenes (IAA500520812)

mice by using lentiviral vectors with liver-specific and controllable expression...

EB - Genetika a molekulární biologie

  • 2008 - 2012
    • •
  • 5 911 tis. Kč
    • •
  • 4 841 tis. Kč
    • •
  • AV ČR
Project

Targeted Depletion of the TRP-VR1 in Murine Nociception Models for Treatment of Analgesics Resistant Pain (LTAB19024)

neuropathic and cancer pain, using innovative lentiviral vector-based bio-therapeutic in vivo. This effect is achieved through targeted lentiviral shRNA interference......

Neurosciences (including psychophysiology)

  • 2019 - 2021
    • •
  • 1 200 tis. Kč
    • •
  • 1 200 tis. Kč
    • •
  • MŠMT
Project

The program of lentiviral infection health check in small ruminants using new methods of early laboratory diagnostics and markers of genetically determined resistance to infection as a selection (QJ1610096)

Objectives of the project are fully in conformity with the objectives of Subprogram I. Thus based on genetic screening suggest program of marker-assisted selection for resistance against lentiviral infections in small ruminants (sheep and pr...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2016 - 2018
    • •
  • 7 323 tis. Kč
    • •
  • 6 585 tis. Kč
    • •
  • MZe
Project

Biomedical model of miniature pigs for testing of new medicaments and for new treatments of traumatic spinal cord injury and neurodegenerative diseases (TA01011466)

of lentiviral vectors for mutated huntingtin. All biomedical models will be offered...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2014
    • •
  • 22 639 tis. Kč
    • •
  • 18 033 tis. Kč
    • •
  • TA ČR
Project

Revealing the pathohysiological function of serine protease kallikrein 14 in vivo using mouse models (GP301/09/P662)

overexpression ofKlk14 in the skin should be generated using a lentiviral vector, which...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 589 tis. Kč
    • •
  • 2 589 tis. Kč
    • •
  • GA ČR
Project

Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes (7E08062)

The project will document and monitor the natural course and study the pathophysiology of Primary Antibody Deficiencies (PAD). PADs are rare inborn errors of the immune system with an estimated incidence of <1:25.000. The defective immunity in patien...

EC - Imunologie

  • 2008 - 2011
    • •
  • 578 tis. Kč
    • •
  • 578 tis. Kč
    • •
  • MŠMT
Project

Membrane signalosomes of mast cells and basophils - targets for innovative therapies (LD12073)

The aim of this project is: 1. To contribute to determining the composition of the FceRI membrane signalosomes important for antigen-induced degranulation in mast cells. 2. To contribute to determining the composition of membrane signalosomes importa...

EC - Imunologie

  • 2012 - 2014
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • MŠMT
Project

Biology and control of vector-borne infections in Europe (7E11055)

components of vector-borne diseases (VBD) introduction, emergence and spread of arthropod vectors involved in the transmission of vector-borne diseases in Europe: ticks health. We have put a strong focus on vector...

EG - Zoologie

  • 2011 - 2014
    • •
  • 2 574 tis. Kč
    • •
  • 2 574 tis. Kč
    • •
  • MŠMT
Project

Transmission and vectors of cutaneous leishmaniasis (GA206/05/0370)

are recently emerging, in which the epidemiology, vectors, and potential reservoirhosts are poorly known or unknown. We plan to study transmission cycle and vectors of cutaneous leishmaniasis in a focus in SE Turkey. Parasite ident...

EE - Mikrobiologie, virologie

  • 2005 - 2007
    • •
  • 2 352 tis. Kč
    • •
  • 1 518 tis. Kč
    • •
  • GA ČR
Project

Avian Sarcoma and Leukosis Virus-based Vectors and Their Potential for Transgenesis in Chicken (GAP502/11/2207)

Retroviruses are important tools as gene delivery vectors for transgenesis. Among retroviruses, there are several reasons for the use of ASLV-based vectors as vectors for transgenesis and even for gene therapy with minimum ...

EB - Genetika a molekulární biologie

  • 2011 - 2015
    • •
  • 5 864 tis. Kč
    • •
  • 5 864 tis. Kč
    • •
  • GA ČR
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