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7 (0,106s) •

Project

Expression of lincomycin biosynthetic gene cluster and its regulation (GA204/05/0616)

the lincomycin biosynthetic cluster and identifying transcription starts. Based on previous results, e.g. the known sequence of the lincomycin biosynthetic gene cluster, respectively. The impact on lincomycin production wi...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 2 466 tis. Kč
    • •
  • 2 466 tis. Kč
    • •
  • GA ČR
Project

The presentation of the results of the study of secondary metabolite production in actinomycetes. (PG99141)

and genetics of production of lincomycine, the important antibiotic drug, commonly used in human medicine; particularly the identification of single genes of lincomycine cluster, acting in last steps of lincomycine biosynt...

EE - Mikrobiologie, virologie

  • 1999 - 1999
    • •
  • 135 tis. Kč
    • •
  • 67 tis. Kč
    • •
  • MŠMT
Project

Genes determining critical steps in designing the producers of hybrid lincosamide antibiotics (IAA500200810)

The project aims to resolve the following findings: 1. High variability of homologous genes of proline building unit synthesis was observed between lincomycin and anthramycin antibiotic producers as well as inside the anthramycin group. To e...

EE - Mikrobiologie, virologie

  • 2008 - 2011
    • •
  • 4 465 tis. Kč
    • •
  • 4 465 tis. Kč
    • •
  • AV ČR
Project

Molecular Biological Study of Lincosamide Antibiotics Biosynthesis (GA204/01/1004)

The aim of the project is to clarify, what genes of the lincomycin gene cluster code for proteins involved in the final steps of the biosynthesis of the antibiotic. In particular, components of the key multisubunit N-demethyllincomycin synth...

EE - Mikrobiologie, virologie

  • 2001 - 2003
    • •
  • 3 766 tis. Kč
    • •
  • 2 641 tis. Kč
    • •
  • GA ČR
Project

Resistance to antibiotics and new derivatives of antibiotics for medical purposes. (PZ-Z2/23)

New or modified antibiotics with improved physico-chemical properties and therapeutic effects. Development of new derivates of lincosamine antibiotics by means of gene engineering or biotransformation.......

FR - Farmakologie a lékárnická chemie

  • 1997 - 2001
    • •
  • 28 602 tis. Kč
    • •
  • 11 300 tis. Kč
    • •
  • MH
Project

Biosynthesis of anthramycin and lincosamide antibiotics, a source of novel hybrid compounds with antibacterial, antimalarial and antitumor activities (GA204/04/0801)

The aim of the project is to acquire a set of complementary biosynthetic genes suitable for preparation of new hybrid antibiotics based on lincomycin. Derivatives of this antibiotic find permanently wider exercise in human medicine in last y...

EE - Mikrobiologie, virologie

  • 2004 - 2006
    • •
  • 3 046 tis. Kč
    • •
  • 3 046 tis. Kč
    • •
  • GA ČR
Project

Unique mechanisms in biosynthesis of secondary metabolites produced by actinomycetes (GJ17-13436Y)

Lincosamides (LSMs) are clinically used antibiotics produced by streptomycetes, which employ two microbial thiols in unprecedented mechanisms for their biosynthesis: ergothioneine for precursor condensation and mycothiol for sulphur incorporation (Zh...

EE - Mikrobiologie, virologie

  • 2017 - 2019
    • •
  • 6 130 tis. Kč
    • •
  • 6 130 tis. Kč
    • •
  • GA ČR
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