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54 (0,166s) •

Project

Making drugs smarter Novel conjugable phosphorus-based linkers for targeted drug delivery (GA23-05752S)

In drug delivery, light-activated, phosphorus, self-immolative (SI) linkers of these linkers and their cargo diversity remain considerably limited, hindering broader applications, and phosphorus SI linkers cannot be conjuga...

Organic chemistry

  • 2023 - 2025
    • •
  • 6 174 tis. Kč
    • •
  • 6 174 tis. Kč
    • •
  • GA ČR
Project

Multilicence for access to the basic medical information resources for science and research (LI01021)

Multilicence access to the basic medical electronic information resources: MEDLINE EXPRESS, EMBASE CD, SILVER LINKER, MICROMEDEX a Prous Science Daily Essentials - Daily Drug News.......

AF - Dokumentace, knihovnictví, práce s informacemi

  • 2001 - 2003
    • •
  • 26 132 tis. Kč
    • •
  • 23 791 tis. Kč
    • •
  • MŠMT
Project

Determination of the histone H5 globular domain position within the native nucleosome using cryo-electron microscopy and single particle reconstruction. (GA304/05/2168)

at physiological concentrations. It is evident that the presence of the linker histone the position of the globular domain of linker histone H5 on native nucleosome using cryo resolve a long lasting ambiguity in the determination o...

EA - Morfologické obory a cytologie

  • 2005 - 2007
    • •
  • 2 661 tis. Kč
    • •
  • 2 639 tis. Kč
    • •
  • GA ČR
Project

Multi-FRET fluorescent probes responding to hydrolases (GA19-23972S)

The project is focused on synthesis of model systems for detection of two or three proteases solely or in their mixture via fluorescence multi-FRET effect. The systems will be based on three/four dyes connected with linkers cleavable will be...

Organic chemistry

  • 2019 - 2021
    • •
  • 5 070 tis. Kč
    • •
  • 5 070 tis. Kč
    • •
  • GA ČR
Project

*Targeted supercancerostatics of new generation for leucemia therapy. (FT-TA2/081)

*Technology of specific ligands production development targeted for complexation of radionuclides. Ligands will be content reactive functional groups for conjugation with monoclonal antibody antiCD66. The conjugate will be applied in leucemia therapy...

CC - Organická chemie

  • 2005 - 2008
    • •
  • 70 398 tis. Kč
    • •
  • 48 451 tis. Kč
    • •
  • MPO
Project

Noninvasive visualization of transplanted cell distribution and viability (GA18-07983S)

-molecular tracer coupled with a caspase-cleavable linker. In a viable cell both tracers are co-localized. The linker is cleaved by a caspase after apoptosis induction......

Radiology, nuclear medicine and medical imaging

  • 2018 - 2020
    • •
  • 7 890 tis. Kč
    • •
  • 7 176 tis. Kč
    • •
  • GA ČR
Project

Phosphinic acid based metal-organic frameworks for removal of emerging pollutants and heavy metals (GA20-04408S)

We aim to synthesize novel metal-organic frameworks (MOF) using phosphinic acid based linkers for removal of emerging pollutants and heavy metals. The high water stability of phosphinate MOFs combined with their chemical variability make the...

Nano-materials (production and properties)

  • 2020 - 2022
    • •
  • 9 809 tis. Kč
    • •
  • 9 569 tis. Kč
    • •
  • GA ČR
Project

Expanding the analytical toolbox for structural mass spectrometry (GA22-27695S)

in proteins. Within this proposal we will expand the cross-linker portfolio by generating a set of novel cross-linkers and adding new features to the existing ones......

Analytical chemistry

  • 2022 - 2024
    • •
  • 6 336 tis. Kč
    • •
  • 6 336 tis. Kč
    • •
  • GA ČR
Project

Novel stationary phases for chromatographic separation of chiral compounds (FV10082)

aims of the project are the following: 1. Electrostatic immobilization of linkers helquats (2017). 3. A system linker-modified cyclodextrin and its electrostatic......

CB - Analytická chemie, separace

  • 2016 - 2019
    • •
  • 20 331 tis. Kč
    • •
  • 15 519 tis. Kč
    • •
  • MPO
Project

UOCHB MSCA Mobility II (EF18_070/0010562)

The project goal is to establish and implement international scientific cooperation by supporting the participation of the IOCB scientific staff at renowned foreign institutions. The project is targeted at employees whose proposal was not supported u...

Organic chemistry

  • 2018 - 2021
    • •
  • 3 669 tis. Kč
    • •
  • 3 669 tis. Kč
    • •
  • MŠMT
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