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792 (0,151s) •

Project

Role of AMP-activated protein kinase in the modulation of lipid metabolism in white adipose tissue (KJB5011303)

of adipocytes affects lipid metabolism via AMP-activated protein kinase (AMPK) and whetherRegulation of lipid metabolism in the adipose tissue has a great impact on the control of the amount of body fat. Previous observati...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 1 823 tis. Kč
    • •
  • 1 049 tis. Kč
    • •
  • AV ČR
Project

Characterization of the molecular machinery regulating the recruitment of signaling molecules to lipid rafts (GA310/09/2084)

of kinase active Lck to lipid rafts (LR). While this event is indispensable for T cellLipid raft-based, plasma membrane compartmentalization processes are essential to early and sequential activation of Src-family tyrosine...

EC - Imunologie

  • 2009 - 2014
    • •
  • 6 750 tis. Kč
    • •
  • 6 750 tis. Kč
    • •
  • GA ČR
Project

In vitro reconstitution of viral “Replication factories“ (GJ15-21030Y)

The main marker of the Golgi and the trans-Golgi network (TGN) – phosphatidyl inositol 4-phosphate (PI4P) - is synthesized by the action of PI4 kinases (PI4Ks) that play key roles in lipid synthesis and cellular trafficking. Further...

CE - Biochemie

  • 2015 - 2017
    • •
  • 5 551 tis. Kč
    • •
  • 5 551 tis. Kč
    • •
  • GA ČR
Project

Rational design of phosphatidylinositol 4-kinase IIalpha inhibitors as tools for chemical biology and potential therapeutics (GA15-09310S)

Phosphatidylinositol 4-kinase IIalpha (PI4KIIa) is an enzyme which belongs to the family of human lipid kinases and which participates on a number of physiological and pathological processes in cells. Among others, it seems...

CC - Organická chemie

  • 2015 - 2017
    • •
  • 5 104 tis. Kč
    • •
  • 5 104 tis. Kč
    • •
  • GA ČR
Project

In-solution study of the lipid kinase PI4KB heteromeric protein complexes (GA17-05200S)

Large dynamic protein complexes cannot be studied by traditional protein crystallography due to their intrinsically disordered regions. Traditional NMR techniques are also not suitable due to their size. Phosphatidylinositol 4-kinase B (PI4K...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 5 616 tis. Kč
    • •
  • 4 734 tis. Kč
    • •
  • GA ČR
Project

Functional and structural heterogeneity of membrane microdomains in mast cells activated via dimerized IgE receptor (GA301/03/0596)

in membrane microdomains (lipid rafts) enriched with Lyn kinase. However, biochemical istyrosinephosphorylation of FceRI subunits by Lyn kinase, followed by activation and phosphorylation of Syk kinase and phospho...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 1 995 tis. Kč
    • •
  • 1 995 tis. Kč
    • •
  • GA ČR
Project

Metabolic flux analysis of carbohydrates and lipids in adipose tissue (LTAUSA17173)

tissue significantly affects the systemic processing of carbohydrates and lipids through novel lipid mediators - branched fatty acid esters of hydroxy fatty acids with a a crucial cellular energy sensor AMP-activated protein ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2019
    • •
  • 2 284 tis. Kč
    • •
  • 2 284 tis. Kč
    • •
  • MŠMT
Project

Multifaceted analysis of diacylglycerol kinase family in plants (GA17-27477S)

Plants as sessile organisms are almost constantly exposed to a huge amount of environmental stress factors, which influence plant survival and also their morphogenesis. Specific (phospho)lipids, particularly phosphatidic acid (PA) and probab...

ED - Fyziologie

  • 2017 - 2021
    • •
  • 6 996 tis. Kč
    • •
  • 6 323 tis. Kč
    • •
  • GA ČR
Project

Role of diacylglacerol-kinases in the plant unfolded protein response (8J20FR032)

Lipid signalling appears to be a major process in plant response to stress and in development. The majority of plant lipids and proteins are synthetized and modified stress”. Recent studies suggest the connection between diacylglyce...

Plant sciences, botany

  • 2020 - 2022
    • •
  • 148 tis. Kč
    • •
  • 148 tis. Kč
    • •
  • MŠMT
Project

Phosphatidic acid and diacylglycerol-mediated signalling in the polar growth of plant cells (IAA601110916)

Membrane phosphoinositides and phosphatidic acid, along with lipases, kinases and phosphatases, control cell polarity and vesicular trafficking in yeast and animal cells the relationship of these two aspects of membrane lipid functi...

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 6 451 tis. Kč
    • •
  • 6 451 tis. Kč
    • •
  • AV ČR
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