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1 264 (0,119s) •

Project

In-silico Workflow for Lipid-Mediated Active Pharmaceutical Ingredients Delivery Systems (GA25-18467S)

Lipid-mediated active pharmaceutical ingredients (APIs) delivery systems have enormous potential for the treatment of cancer or rare diseases. Lipid nanocarriers simulations of lipid-mediated API delivery ...

Physical chemistry

  • 2025 - 2027
    • •
  • 5 109 tis. Kč
    • •
  • 5 109 tis. Kč
    • •
  • GA ČR
Project

Metabolic flux analysis of carbohydrates and lipids in adipose tissue (LTAUSA17173)

tissue significantly affects the systemic processing of carbohydrates and lipids through novel lipid mediators - branched fatty acid esters of hydroxy fatty acids) and to characterize the role of FAHFA mediators ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2019
    • •
  • 2 284 tis. Kč
    • •
  • 2 284 tis. Kč
    • •
  • MŠMT
Project

Structural and functional analysis of regulation of the lipid-transport protein ORP8 (GF21-27735K)

Lipids transport between various membranous intracellular organelles is mediated either by the well described vesicular transport or by a conserved protein family specialized in transporting lipids. Oxysterol-binding protei...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 4 220 tis. Kč
    • •
  • 3 260 tis. Kč
    • •
  • GA ČR
Project

Metabolic and regulatory effect of lipids in artificial nutrition. (IZ4095)

Clinical experimental study of the pharmacological and metabolic effect off lipids on: a) cell membrane structure b) cell membrane function mediators c) cytokinetics and cell proliferation......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1997 - 1999
    • •
  • 2 037 tis. Kč
    • •
  • 1 942 tis. Kč
    • •
  • MZ
Project

Modulation of Fatty Acid Reesterification in Adipose Tissue by Lipid Mediators (LH14040)

of bioactive lipids, lipid mediators, in the regulation of reesterification in adipocytes lipids. We will explore regulation of reesterification by eicosanoids, docosanoidsand......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2014 - 2016
    • •
  • 1 910 tis. Kč
    • •
  • 1 910 tis. Kč
    • •
  • MŠMT
Project

Changes of lipid metabolism and its mediator-related effects in patients with colorectal carcinoma - perspective impact in nutritional support. (NC6171)

The aim is to obtain data on the effects of lipids used in artificial nutrition (mainly PUFA n-3) upon characteristic of colored carcinoma in cell culture (metabiloc changes, proliferation, apoptosis). Is it possible ti find similar changes ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 5 105 tis. Kč
    • •
  • 2 178 tis. Kč
    • •
  • MZ
Project

New metabolic pathways of lipid trafficking (LUAUS24040)

quantitative analysis of intra- and inter-cellular transport of lipids, specifically fatty acids and FAHFA lipokines. 1. Transcytosis in lipid transport 1.1 To trace the fate the composition of lipid cargo directed to extr...

Biochemistry and molecular biology

  • 2024 - 2027
    • •
  • 10 122 tis. Kč
    • •
  • 10 122 tis. Kč
    • •
  • MŠMT
Project

Enhancing energy expenditure in white adipose tissue by combination treatments using n-3 fatty acids, resveratrol and calorie restriction (GA13-00871S)

were associated with synergistic up-regulation of anti-inflammatory lipid mediators in WAT by the treatment; 3) the integrating role of lipid mediators and PPARg%-calorie restriction (CR) and 9%-replacement of

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2013 - 2017
    • •
  • 9 962 tis. Kč
    • •
  • 9 640 tis. Kč
    • •
  • GA ČR
Project

Bottom-up unraveling of biophysical determinants of ORP5/8 mediated lipid transport using in vitro reconstitution and model membranes (GA19-18917S)

Membrane homeostasis requires organized transport of lipids from (ORPs) represent a family of lipid transfer proteins, two members of which, ORP5/8 cargo lipids are exchanged for one another. Yet, the biophysical understand...

Biochemistry and molecular biology

  • 2019 - 2021
    • •
  • 3 705 tis. Kč
    • •
  • 3 705 tis. Kč
    • •
  • GA ČR
Project

Anti-inflammatory effects of novel lipokines of fatty acid esters of hydroxy fatty acids family in obesity (GJ17-10088Y)

and exert beneficial metabolic effects. In 2014, a class of WAT-born lipid mediators of the mechanisms connecting inflammation, metabolism, and nutritional lipids.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2019
    • •
  • 5 609 tis. Kč
    • •
  • 5 609 tis. Kč
    • •
  • GA ČR
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