Filters
Show less
Show less
Show less
Show less
Show less
More filters
Projects
Liposoms (drug delivery systems) in kinetically guided therapy of ovarian platinum-resistent carcinoma with doxorubicin using plasmafiltration. (NV16-30366A)
An anti-cancer drug, doxorubicin, encapsulated in small-sized pegylated liposomes (PLD) is indicated for second-line treatment of ovarian cancer and AIDS-related Kaposi´s sarcome. PLD shows a lower uptake by RES, and consequently, increased ...
FD - Onkologie a hematologie
- 2016 - 2019 •
- 10 390 tis. Kč •
- 9 910 tis. Kč •
- MZ
Řešení projektu: 1. 4. 2016 - 31. 12. 2019
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Ministerstvo zdravotnictví
Changes in surface saccharides in cells exposed to HPMA-based therapeutics. (GP305/07/P172)
Conjugation of the routinely used anticancer drug doxorubicin to N-(2 treatment. Inside the cell, doxorubicin - either the parent drug or the drug apoptosis. On the other hand, conjugates containing aminolytically bound doxorubi...
EC - Imunologie
- 2007 - 2009 •
- 1 494 tis. Kč •
- 1 494 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The Assessment of Late Doxorubicin-Induced Cardiotoxicity in Adults Treated for Malignant Lymphoma (NC7354)
The assessment of clinical value of early changes of LV function during the treatment for late onset of cardiotoxicity. The assessment of the incidence of late cardiotoxicity 5-7 yrs after the chemotherapy. The assessment of the contribution of nonin...
FC - Pneumologie
- 2003 - 2005 •
- 1 476 tis. Kč •
- 1 468 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2003 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
*Preclinical trials of polymer bound cytostatic and synthesis scale-up transfer from laboratory conditions. (FI-IM2/111)
*Realization of preclinical testing of highly perspective anticancer drug, which is bound via pH-sensitive bond to water-soluble polymer carrier. Further aims include management of its manufacturing at scale-up measure and implementation and validati...
FD - Onkologie a hematologie
- 2005 - 2008 •
- 35 077 tis. Kč •
- 10 816 tis. Kč •
- MPO
Řešení projektu: 2. 1. 2005 - 30. 6. 2008
Uznané náklady
Podpora ze státního rozpočtu (31%)
Poskytovatel: Ministerstvo průmyslu a obchodu
Mechanism of action of polymeric drugs and their intracellular distribution (GP305/04/P004)
At present, the polymeric conjugates based on poly N-(2-hydroxypropyl)-methacrylamide (HPMA) [1-7] are used as a carriers for anticancer drug - doxorubicin. Conjugation of doxorubicin with a polymeric carrier and optionally targeted...
EC - Imunologie
- 2004 - 2006 •
- 851 tis. Kč •
- 851 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Kinetically guided removal of plazma pegylated liposomal doxorubicin to enhance the benefit of cytostatic therapy of patients with ovarian cancer. (NT14035)
. For the therapy with rheohemapheresis we suggest to use pegylated liposomal doxorubicine...
FD - Onkologie a hematologie
- 2013 - 2015 •
- 4 967 tis. Kč •
- 4 967 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2013 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Hybrid magnetic "stealth" nano-structures for the targeted and controlled release of doxorubicin (7AMB12GR026)
The present research proposal aims to advance a step further the design and performance of physically targeted drug nanocarriers for cationic drugs such as doxorubicin - a potent drug but with serious side effects. Therefore, new multifuncti...
CA - Anorganická chemie
- 2012 - 2013 •
- 114 tis. Kč •
- 114 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 2012 - 31. 12. 2013
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Chemical biology approach to study anthracycline cardiotoxicity and pharmacological cardioprotection with focus on topoisomerase II beta (GA21-16195S)
Anthracyclines (e.g., doxorubicin, daunorubicin) rank among the important anticancer drugs, but their usefulness is limited by risk of toxic myocardial injury and heart failure development. In recent years there have been paradigm shift from...
Pharmacology and pharmacy
- 2021 - 2023 •
- 10 035 tis. Kč •
- 10 035 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2021 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Effect of polyphenols and chelators on toxicity and effects of anthracyclines and taxanes (NL7567)
effects of polyphenols and chelators on cardiotoxicity of doxorubicin and epirubicin of doxorubicin and epirubicin will observe their influence on dose-related induction......
FR - Farmakologie a lékárnická chemie
- 2003 - 2005 •
- 5 395 tis. Kč •
- 2 443 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2003 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (45%)
Poskytovatel: Ministerstvo zdravotnictví
Behavior and shape of nanoparticles – anticancer drug carriers in real blood environment. (LH15213)
The main aim of the proposal is to investigate the inner structure of nanoparticles composed of tumor-targeted polymer-doxorubicin conjugates in real blood environment. Precise distribution of all entities (cholesterol and drug) will be esta...
CD - Makromolekulární chemie
- 2015 - 2017 •
- 2 454 tis. Kč •
- 1 835 tis. Kč •
- MŠMT
Řešení projektu: 13. 10. 2015 - 31. 12. 2017
Uznané náklady
Podpora ze státního rozpočtu (75%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
- 1 - 10 out of 40