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3 252 (0,187s) •

Project

Callose synthases - dynamics and mechanisms of secretion. (GA18-12579S)

of the evidence is genetic and subcellular localization studies are almost absent, despite the fact that specific localization and rapid secretion are essential for their function. In our previous project, we showed that c...

Plant sciences, botany

  • 2018 - 2023
    • •
  • 4 949 tis. Kč
    • •
  • 4 949 tis. Kč
    • •
  • GA ČR
Project

Uncovering the role of diacylglycerols in regulation of insulin secretion from β-cells (GA19-21318S)

β-Cell failure leading to insufficient secretion of insulin is central secretion regulation by these lipids are still poorly understood. In this project we aim to elucidate the role of DAGs in regulation of insulin secretion

Endocrinology and metabolism (including diabetes, hormones)

  • 2019 - 2020
    • •
  • 2 671 tis. Kč
    • •
  • 2 497 tis. Kč
    • •
  • GA ČR
Project

Interplay of MLO and exocyst complex proteins in localized secretion in plant cells (GC19-02242J)

Mechanisms of the targeted secretion as a part of cell polarity processes in plants are only poorly understood. In our joint project, we aim to elucidate the molecular mechanism of MLO protein activity in the context of exocyst function in p...

Cell biology

  • 2019 - 2023
    • •
  • 5 579 tis. Kč
    • •
  • 5 579 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of action of Bordetella type III secretion effector BteA (GJ18-16772Y)

Whooping cough (pertussis) occurrence in the most developed countries is steadily increasing despite massive vaccination programs. This calls for better understanding of Bordetella pertussis pathogenesis. The functional type III secretion sy...

Microbiology

  • 2018 - 2021
    • •
  • 8 081 tis. Kč
    • •
  • 8 081 tis. Kč
    • •
  • GA ČR
Project

Exploring the structure function relationship of membrane-pore-forming FGF2 oligomers - a single molecule approach (GC20-01401J)

Fibroblast Growth Factor 2 (FGF2) is a cell survival factor mediating tumor-induced angiogenesis. As opposed to the majority of extracellularly localized proteins, FGF2 is secreted from cells by direct protein translocation across t...

Biophysics

  • 2020 - 2022
    • •
  • 4 953 tis. Kč
    • •
  • 4 616 tis. Kč
    • •
  • GA ČR
Project

The relationship between nutrition and secretion of adipocytokines and other proteins in adipose tissue (NR9161)

In group of 20 obese women it will be observed secretion of adipocytokines and secretion of proposed proteins contributed to the pathogenesis of metabolicsyndrome. 2. to what degree is it possible to effect alternative secretion...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 3 958 tis. Kč
    • •
  • 3 629 tis. Kč
    • •
  • MZ
Project

Passive intelligent sensors service for obtaining and transfer of on-line data about appearance and kind of power electromagnetic wave threatening environs (OSVTUPV200802)

localization and to provide radio secret transmission of obtained data in terms of alliance...

KA - Vojenství

  • 2008 - 2010
    • •
  • 10 509 tis. Kč
    • •
  • 10 509 tis. Kč
    • •
  • MO
Project

Pathogenic Candida strains typing and characterization of secreted proteinases (NI6485)

Candida isolates from routine clinical screening will be identified, typed by RAPD and screened for secreted proteinase production. Odds method will be modified for rapid monitoring of proteinase secretion by Candida cultures. Inhib...

EE - Mikrobiologie, virologie

  • 2001 - 2003
    • •
  • 1 765 tis. Kč
    • •
  • 1 297 tis. Kč
    • •
  • MZ
Project

Induction and inhibition of isoenzymes of the aspartic proteinases secreted by the yeast belonging to the genus Candida (GA303/98/P252)

proteinases secreted by the Candida yeast are believed to act as one of the virulence proteins and immunoglobulins. Therefore, the secreted aspartic proteinases to design and synthesis of efficient and selective inhibitors of Candi...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1998 - 2001
    • •
  • 762 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • GA ČR
Project

The role of Arabidopsis Lorelei-like GPI anchored proteins (LLGs) in pollen tube reception by the female gametophyte (LTAUSA18115)

and chemotropic components. Small GPI-anchored protein LORELEI (LRE) secreted by synergid is a member of a Lorelei-like family of small secreted GPI-anchored proteins, which to the investigation of the coordinated role of small

Plant sciences, botany

  • 2019 - 2022
    • •
  • 6 801 tis. Kč
    • •
  • 6 801 tis. Kč
    • •
  • MŠMT
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