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435 (0,131s) •

Project

Experimental therapy and receptor mechanism of benzodiazepine dependence studied by PCR in situ. (IZ3612)

FL - Psychiatrie, sexuologie

  • 1996 - 1998
    • •
  • 1 457 tis. Kč
    • •
  • 1 457 tis. Kč
    • •
  • MZ
Project

Integration of novel RNA-nanotherapeutics in patient-derived breast cancer organoids (NU23J-08-00035)

RNA-based therapy is revolutionizing the healthcare strategy worldwide. The flexible design of RNA molecules combined with the scalability and tunability of lipid nanoparticles, make RNA-nanotherapeutics a promising candidate for the establishment of...

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 6 894 tis. Kč
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  • 6 894 tis. Kč
    • •
  • MZ
Project

Transplantation therapy of diabetes with insulin-producing cells derived by reprogramming of non-endocrine pancreatic cells (NV15-25924A)

reprogramming that is based on the application of synthetic modified mRNA could solve all these issues. Therefore we propose to use synthetic modified mRNAs encoding key......

FJ - Chirurgie včetně transplantologie

  • 2015 - 2018
    • •
  • 6 146 tis. Kč
    • •
  • 6 146 tis. Kč
    • •
  • MZ
Project

Regulation of gene expression by a new mRNA-binding factor (GA16-10930S)

Recent studies have shown that more mRNA-binding proteins (mRBP) exist than that one of the tCDK binds mRNA directly in living cells via its conserved region, making it the first mRNA-binding CDK. We hypothesize that the

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 9 396 tis. Kč
    • •
  • 9 396 tis. Kč
    • •
  • GA ČR
Project

Mapping mRNP-NUP interactions during nuclear export with a unique mRNA-trap (GC21-19503J)

Eukaryotic mRNAs need to pass through the nuclear pores to reach the cytoplasm. Study of nuclear mRNA export is challenging, because it is fast, and interactions immature mRNAs from starting nuclear export. As a consequence...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 6 437 tis. Kč
    • •
  • 6 437 tis. Kč
    • •
  • GA ČR
Project

Quantification and localization of maternal mRNAs in early development of Xenopus (KJB500520601)

on protein and mRNA cell content and distribution. mRNA profiling is limited by small and eggs contain enough mRNA for extensive screening. I therefore, propose, by real-time PCR, to quantify mRNA levels of 40 hig...

EB - Genetika a molekulární biologie

  • 2006 - 2007
    • •
  • 720 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • AV ČR
Project

MicroRNA expression during early development of Xenopus laevis and mRNA degradation (IAA500970904)

Cells fate and differentiation depend on precise controlled mRNA and protein expression and degradation. Expression of mRNA has been extensively studied cleavage. In most cases mRNA decay is thought to be stimulated by miRN...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 820 tis. Kč
    • •
  • 2 820 tis. Kč
    • •
  • AV ČR
Project

Betulinic acid derivatives, identification of mechanism of anticancer action based on expression profiling. (GP301/09/P433)

(profiling of mRNA/proteins)of a treated CEM cancer cell line. The expression profiles...

FR - Farmakologie a lékárnická chemie

  • 2009 - 2011
    • •
  • 1 167 tis. Kč
    • •
  • 1 167 tis. Kč
    • •
  • GA ČR
Project

Toll-like receptors in prostate carcinogenesis and therapy resistance (NV17-28518A)

-3, -4, and -9. Their expression at mRNA and protein level will be investigated...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 14 546 tis. Kč
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  • 14 531 tis. Kč
    • •
  • MZ
Project

Alternative drugs for mastitis therapy (RE0930950038)

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 1993 - 1995
    • •
  • 980 tis. Kč
    • •
  • 1 960 tis. Kč
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  • MZe
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