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610 (0,076s) •

Project

The therapeutic potential of novel mTOR inhibitors within the process of ageing (GA20-22037S)

. The mechanism of its action is through inhibition of mTOR activity. However, this drug has non-selectivity towards mTOR complexes) and inability to penetrate the blood-brain and in vivo evaluation of novel mTOR i...

Pharmacology and pharmacy

  • 2020 - 2022
    • •
  • 11 525 tis. Kč
    • •
  • 11 525 tis. Kč
    • •
  • GA ČR
Project

Establishing the signaling pathway associated with secondary injury, reactive oxygen species and inflammation in spinal cord injury and during its repair. (LTAUSA17120)

To study signalling pathways activated during spinal cord injury, particularly mTOR pathway in cells and in spinal cord tissue. To study inhibition of mTOR pathway using blocators of mTORC1 or mTORC2 complex. To study the e...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2020
    • •
  • 7 673 tis. Kč
    • •
  • 7 673 tis. Kč
    • •
  • MŠMT
Project

The role of mTOR (mammalian target of rapamycin) pathway in the antidepressive effect of ketamine and antidepressive drugs in patient with depressive disorder translation study (NT13403)

The aim of animal part of this project is to determine whether activation (ketamine) or inhibition (rapamycin) of mTOR signaling pathway have antidepressant responders differs from ketamine non-responders a) in the activation of

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
    • •
  • 9 790 tis. Kč
    • •
  • 9 790 tis. Kč
    • •
  • MZ
Project

Alzheimer´s disease and aging can mTOR inhibitors kill two birds with one drug? (GA23-05857S)

of AD brains demonstrated upregulation of mTOR signaling during the neurodegenerative development. Moreover, recent studies pointed out that mTOR inhibition, synthesize and biological evaluation of novel centrally active <...

Pharmacology and pharmacy

  • 2023 - 2025
    • •
  • 10 014 tis. Kč
    • •
  • 10 014 tis. Kč
    • •
  • GA ČR
Project

Control of mTOR and MAPK pathways by Src tyrosine kinase activity - implication for cancer therapy by protein kinase inhibitors (NT11231)

results in the inhibition of the serine/threonine-specific phosphorylation of effector proteins in the mTOR signalling pathway. It indicates that, besides rapamycin and its in the deregulated signalling of two important pathways, t...

FD - Onkologie a hematologie

  • 2010 - 2013
    • •
  • 3 723 tis. Kč
    • •
  • 3 723 tis. Kč
    • •
  • MZ
Project

Morphological changes of liver tissue after the transplantation of pancreatic islets (NT14240)

was reported after Tx of islets. In this project, the LC protection by mTOR inhibitor. The expression analysis of mTOR and insulin signaling cascades will be performed to identify......

FJ - Chirurgie včetně transplantologie

  • 2013 - 2015
    • •
  • 5 458 tis. Kč
    • •
  • 5 458 tis. Kč
    • •
  • MZ
Project

The effect of normalization of blood glucose levels in pancreas graft recipients on advanced diabetic retinopathy (NV15-26746A)

suggests that inhibition of the mammalian target of rapamycin (mTOR) might beneficially of the project is to test hypothesis that systemic treatment with everolimus, an mTOR......

FJ - Chirurgie včetně transplantologie

  • 2015 - 2019
    • •
  • 8 904 tis. Kč
    • •
  • 8 904 tis. Kč
    • •
  • MZ
Project

Development of novel activators of mTOR signaling pathway as adjunct therapy in treatment-resistant depression (NW24-04-00422)

(TRD). Mechanistic target of rapamycin (mTOR) signaling pathway is implicated relationship between the circadian clock and mTOR was discovered. Accordingly, dysregulation of the mTOR signaling pathway has been found in a v...

Pharmacology and pharmacy

  • 2024 - 2027
    • •
  • 13 292 tis. Kč
    • •
  • 13 292 tis. Kč
    • •
  • MZ
Project

PRIORITIZING DRUG COMBINATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA BASED ON ANALYSIS OF CELL ADAPTATION TO IBRUTINIB AND IDELALISIB IN VIVO (NU20-03-00292)

that malignant B cells utilize in vivo to adapt and survive BTK inhibition (and potentially PI3K inhibition). We will further study these molecular pathways and pre-clinically......

Cell biology

  • 2020 - 2023
    • •
  • 11 446 tis. Kč
    • •
  • 11 446 tis. Kč
    • •
  • MZ
Project

Epigenetic intervention as a tool improving the outcomes of pancreatic islet transplantation (GA14-03305S)

. We will inhibit some members of apoptosis cascade, some regulators of mTOR molecule. The inhibition of tissue tromboplastin will reduce the activity of post the inhibition of one selected gene at the level of mRN...

FJ - Chirurgie včetně transplantologie

  • 2014 - 2018
    • •
  • 5 475 tis. Kč
    • •
  • 5 475 tis. Kč
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  • GA ČR
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