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8 (0,125s)

Project

Improving the quality of life in patients with stable maculopathy by implanting intraocular macula lenses and modulating visual plasticity by transcranial electrical stimulation (NV18-06-00484)

A sight loss is the most severe manifestation of the visual organ failure and it causes severity-dependent decrement in quality of life comparable to heart diseases or cancer. Macular degenerations are leading cause of legal blindness in the develope...

Otorhinolaryngology

  • 2018 - 2022
  • 7 863 tis. Kč
  • 7 863 tis. Kč
  • MZ
Project

Telerehabilitation of visually impaired seniors with macular degeneration - a comparative study of quality of life and visual functions after macular lens implantation or monocular dioptric hypercorrection (NU22-06-00039)

Loss of central vision (macular degeneration) at a later age reduces the quality of life, increases the risk of depression, shortens life expectancy, and is the most common cause of the most serious visual organ failure (legal blindness) in developed...

Ophthalmology

  • 2022 - 2026
  • 8 871 tis. Kč
  • 8 871 tis. Kč
  • MZ
Project

Proprotein convertase subtilisin/kexin 9 (PCSK9) in the pathophysiology a treatment of dry age-related macular degeneration (NV17-29241A)

Proprotein convertase subtilisin/kexin 9 (PCSK9) is a secreted regulator of cell surface low density lipoprotein (LDL) cholesterol receptor levels. Decrease of PCSK9 is a promising area of therapeutic development for hypercholesterolemia and associat...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2020
  • 9 814 tis. Kč
  • 9 814 tis. Kč
  • MZ
Project

Age related macular degeneration. Frequency, pathofysiology, therapy. (IZ2342)

9F - 9

  • 1994 - 1996
  • 248 tis. Kč
  • 372 tis. Kč
  • MZ
Project

Diagnostic markers and pathophysiological mechanisms of atypical parkinsonian syndromes (NT12288)

The project is designed to study clinical and paraclinical markers with a high positive predictive diagnostic value for atypical parkinsonian syndromes and to investigate the contribution of the inhibitory GABA-ergic system in the disorders of gait, ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2015
  • 8 122 tis. Kč
  • 8 122 tis. Kč
  • MZ
Project

Development towards therapy of macular degeneration of retina by derivatives of human pluripotent stem cells (NU22-08-00629)

Age-related macular degeneration (AMD) is polyfactorial age-onset degenerative disease of the retina, which is the most prevalent eye disease affecting Western population. Incidence of AMD is expected to dramatically increase in the future as life ex...

Developmental biology

  • 2022 - 2025
  • 11 253 tis. Kč
  • 11 253 tis. Kč
  • MZ
Project

Correlation of modelling hemodynamic parameters with histological changes in the wall of cerebral aneurysms (NV17-32872A)

The number of patients incidentally diagnosed for a brain aneurysm, the rupture of which may lead to the most severe type of stroke, is increasing. Modelling hemodynamics in brain aneurysms tries to describe pathophysiology and the risk of rupture of...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2020
  • 8 614 tis. Kč
  • 8 104 tis. Kč
  • MZ
Project

Application of retinal cells and organoids in functional diagnostics and treatment of vision loss in Bardet-Biedl syndrome (NU22-07-00380)

Inherited retinal diseases are a genetically heterogeneous group of rare eye disorders with a progressive manifestation causing vision loss, affecting approximately one in 2,000 individuals worldwide. An increasing number of genes have been associate...

Ophthalmology

  • 2022 - 2025
  • 10 915 tis. Kč
  • 10 915 tis. Kč
  • MZ
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