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713 (0,098s) •

Project

Immunological characteristics of lymphomas in childhood (NS10480)

Flow cytometry is an important and fast method in diagnostic process of hematological malignancies. We will analyze by flow cytometry tumor cells and composition of non malignant background in children with lymphomas. The findings w...

FG - Pediatrie

  • 2009 - 2011
    • •
  • 6 340 tis. Kč
    • •
  • 6 340 tis. Kč
    • •
  • MZ
Project

Good clinical practice in treatment of acute lymphoblastic leukemia and other malignancies in childhood by methotrexate hepatotoxic effects of methotrexate. (IZ1199)

9G - 9

  • 1992 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MZ
Project

Signs of accelerated aging as late effect of therapy for childhood cancer and as risk factor of subsequent malignant neoplasms. (NV19-03-00245)

Survivors of childhood cancer have laboratory signs of accelerated aging, especially telomere shortening which is caused by chemotherapy and /or by radiotherapy. It was described increased risk of cancer in persons with shorter telomeres in ...

Oncology

  • 2019 - 2022
    • •
  • 6 289 tis. Kč
    • •
  • 6 289 tis. Kč
    • •
  • MZ
Project

Late sequelae of treatment of Hodgkin's disease in children and adolescents in long-term remission (NC6756)

Late sequelae of patients treated in childhood and adolescence for Hodgkin´s disease, combined retrospective and cross-over study. It is focused not only on the "major" complicationds (second malignancies) but also on the "minor" on...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 2 062 tis. Kč
    • •
  • 2 055 tis. Kč
    • •
  • MZ
Project

Automonous circulations functions,myocard and cardiorespiratory functions in children and adolescents after malignancy treatment. (NR8006)

Patients treated during childhood for malignancy with cardiotoxical anthracycline treatment are risk group for development of cardiovascular diseases in adulthood. Frequence of anthracycline cardiotoxicity is connected with total do...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 1 378 tis. Kč
    • •
  • 1 365 tis. Kč
    • •
  • MZ
Project

Clinical application of molecular diagnostic approaches of gene rearrangements in malignant tumors in childhood (NM6)

Morphological diagnostics of sarkomas and lymphomas is laborious.Detection of gene rearrangements improves the tumor diagnosis,determines bone marrow dissemination and minimal residual disease. The purpose is to improve prognosis of patients with hig...

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 2 542 tis. Kč
    • •
  • 2 542 tis. Kč
    • •
  • MZ
Project

Expression pattern of WT1 gene isoforms and mutational status as a new pathogenetic and diagnostic marker in paediatric haematological malignancies (NS10488)

WT1 gene is potentially an important marker with hematological malignancies. Its role in malignant and normal cells is presumably influenced by the expression original methodology we will identify expression patterns of WT1 isoforms...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 5 270 tis. Kč
    • •
  • 5 270 tis. Kč
    • •
  • MZ
Project

AML1 gene and HOX genes in pathogenesis of childhood acute leukaemias (NR9526)

The main goal of this project is to show the direct relationship between the HOX genes and AML1 transcription factor in normal and malignant haematopoiesis, elucidating the process of malignant transformation of blood cells leading ...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 7 534 tis. Kč
    • •
  • 7 531 tis. Kč
    • •
  • MZ
Project

Ovarian germ cell tumours in childhood and adolescence. Retrospektive clinical-pathologic study. (NC6511)

Retrospective study is found on group of 180 patients, in whose ovarian germ cell tumours were treated in childhood and adolescence (from 0 to 08 years) in hospital of Motol in 1980-2000. One hundred and patients have benign and 70 malig...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 830 tis. Kč
    • •
  • 824 tis. Kč
    • •
  • MZ
Project

Non-random abberant changes in childhood acute leukemias. Cytometric and molecular-genetic studies. (NE7430)

Immunophenotypingof acute leukemias (AL) is an important part of their diagnostics. This projekct will be a continuation of a complex research of childhood AL, which combines the analysis of immunophenotype with molecular-genetic and other t...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 3 155 tis. Kč
    • •
  • 3 124 tis. Kč
    • •
  • MZ
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