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5 874 (0,141s) •

Project

Biosynthesis of asukamycin polyketide chains Prospects for hybrid antibotics (KJB5020306)

Manumycin-type antibiotics, produced by some streptomycete strains, are mainly studied for their putative anticancer and antiinflammatory effects. The metabolites typically consist of two cyclic carbon unitslinked by two po...

EE - Mikrobiologie, virologie

  • 2003 - 2005
    • •
  • 1 267 tis. Kč
    • •
  • 1 109 tis. Kč
    • •
  • AV ČR
Project

Analysis of gene clusters involved in biosynthesis of manumycin-type metabolites (GA310/03/0285)

The aim of the proposal is to isolate and to characterise gene clusters responsible for biosynthesis of manumycin-type secondary metabolites. One member. Weassume that the entire gene cluster implicated in the antibiotic bi...

EE - Mikrobiologie, virologie

  • 2003 - 2005
    • •
  • 4 617 tis. Kč
    • •
  • 4 617 tis. Kč
    • •
  • GA ČR
Project

Identification and isolation of new secondary metabolites with anti-inflammatory and anti-apoptotic features from actinomycetes. (2B06154)

The aim of the project is to isolate and to characterise new compounds related to manumycin-type metabolites. Significant enzyme-inhibitory activities of these compounds of new actinomycete production strains that produce new ty...

EE - Mikrobiologie, virologie

  • 2006 - 2011
    • •
  • 16 799 tis. Kč
    • •
  • 15 119 tis. Kč
    • •
  • MŠMT
Project

New manumycins by means of the specific genetic screening of natural streptomycete isolates and of the combinatorial biosynthesis (LH12191)

The aim of the project is to create a collection of producer strains synthesizing new manumycin-type compounds. About 1/3 - 1/2 of producers will be acquired by means of a genetic screening of streptomycete isolates from various bio...

EE - Mikrobiologie, virologie

  • 2012 - 2015
    • •
  • 2 375 tis. Kč
    • •
  • 2 375 tis. Kč
    • •
  • MŠMT
Project

Gene screening of actinomycetes producing new substances with potential therapeutic applications to modulate immune mechanisms. (IAA600660607)

The project aims to acquire new secondary metabolites of the manumycin type from soil-isolated actinomycetes. These non-steroidal compounds show interesting immunomodulatory features (IL-1ß convertase inhibition) that could potentia...

EE - Mikrobiologie, virologie

  • 2006 - 2008
    • •
  • 4 337 tis. Kč
    • •
  • 4 337 tis. Kč
    • •
  • AV ČR
Project

Seeking and analysis of gen crowds,which cooperating on biosyntesis of manumycin type antibiotic. (ME 707)

Project wants to:perform search(screening)of new potential producers of secondary metabolit,analyse of tribe with positive reaction,isolation and characteristic of gens which are responsible for metabolic processes of trunks.......

EE - Mikrobiologie, virologie

  • 2003 - 2004
    • •
  • 1 299 tis. Kč
    • •
  • 993 tis. Kč
    • •
  • MŠMT
Project

The effect of manumycin-related compounds on innate immunity cells and their interactions (NT13012)

Biological effects of manumycin-related compounds will be tested using a tissue culture models with human monocyte/macrophages (THP-1) and epithelial cell lines screening will be used for identification of streptomycete strains producing

EC - Imunologie

  • 2012 - 2015
    • •
  • 7 827 tis. Kč
    • •
  • 7 827 tis. Kč
    • •
  • MZ
Project

Molecular typing of bacteriocins produced by strains of Escherichia coli isolated from clinical material identification of colicin and microcin types among commensal and pathogenic strains (NS9665)

will be tested on production of bacteriocin types and on spectra of resistance to antibiotics. 31 bacteriocin types and more than 10 antibiotics are to be tested in each strain. The goal of this proposal is to ide...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 5 023 tis. Kč
    • •
  • 5 023 tis. Kč
    • •
  • MZ
Project

Proteomic analysis of adaptive mutations in antibiotic resistant bacteria during long time cultivations (GA310/03/0292)

of antibiotic-resistant bacteria as a result of an increased use of antibiotics both in humans and animals. It was observed quite often that when the antibiotic is removed of the organismsand sometimes also restores lost v...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
    • •
  • 2 296 tis. Kč
    • •
  • 2 296 tis. Kč
    • •
  • GA ČR
Project

Cattle excrements and manure as a reservoir of acinetobacters representing risk to human health (GA22-05373S)

Acinetobacter is a diverse bacterial genus adapting to various types pathogens, of which A. baumannii can be resistant to all medically relevant antibiotics. Manure from antibiotic-treated livestock is an important source o...

Microbiology

  • 2022 - 2024
    • •
  • 12 121 tis. Kč
    • •
  • 12 121 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 5 874