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7 852 (0,103s) •

Project

Molecular mechanisms of membrane interaction and translocation of adenylate cyclase toxin from Bordetella pertussis (GA15-09157S)

. The molecular mechanism of CyaA-membrane interaction and AC translocation remains poorly to a pore-forming cytolysin, which inserts into cellular membranes and mediates translocation of the AC domain dir...

CE - Biochemie

  • 2015 - 2017
    • •
  • 5 994 tis. Kč
    • •
  • 5 994 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase (IAA5020406)

mechanisms underlying membrane insertion and translocation of ACT. Structures involved status, membrane topology, mechanism of formation and signaling role of ACT channels example of direct translocat...

CE - Biochemie

  • 2004 - 2008
    • •
  • 6 250 tis. Kč
    • •
  • 5 910 tis. Kč
    • •
  • AV ČR
Project

Investigation of mechanism of membrane translocation of the adenylate cyclase toxin (IAA5020611)

is a rare example of translocation of a protein from extracellular space into cells directly across their cytoplasmic membrane. It appears to occur without the need fora dedicated translocation machinery other than the tox...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 1 826 tis. Kč
    • •
  • 1 571 tis. Kč
    • •
  • AV ČR
Project

Investigation of the mechanism of membrane translocation of the adenylate cyclase toxin (IAA5020907)

of spontaneous protein translocation directly across the cellular membrane. Elucidation of its molecular mechanism is of general importance for understanding the protein-membrane interactions and is the principal ...

CE - Biochemie

  • 1999 - 2003
    • •
  • 7 321 tis. Kč
    • •
  • 4 975 tis. Kč
    • •
  • AV ČR
Project

Structural and functional analysis of Bordetella pertussis adenylate cyclase toxin action (GA16-05919S)

with the membrane and controls translocation of the AC domain across the membrane, as well of this domain of CyaA and to define its mechanism of interaction with cell membrane. We will in particular addre...

CE - Biochemie

  • 2016 - 2018
    • •
  • 8 250 tis. Kč
    • •
  • 8 229 tis. Kč
    • •
  • GA ČR
Project

Exploring the structure function relationship of membrane-pore-forming FGF2 oligomers - a single molecule approach (GC20-01401J)

into the molecular mechanism of FGF2 membrane translocation at an unprecedented level of detail, FGF2 is secreted from cells by direct protein translocation across the plasma membrane. Several lines of ev...

Biophysics

  • 2020 - 2022
    • •
  • 4 953 tis. Kč
    • •
  • 4 616 tis. Kč
    • •
  • GA ČR
Project

Amphiphilic Peptides at Phospholipid Membranes (GA17-11571S)

of the membrane on the different permeabilization mechanisms. The obtained understandingPhospholipid membranes are a vital component of all cells, with a semipermeable into their behavior, we still lack a full understandin...

CF - Fyzikální chemie a teoretická chemie

  • 2017 - 2021
    • •
  • 4 803 tis. Kč
    • •
  • 4 803 tis. Kč
    • •
  • GA ČR
Project

Apoptosis-inducing factor (AIF) its translocation from mitochondria and its action on nuclear chromatin (GP204/03/D031)

nucleus. We will also study the mechanism of translocation of AIF and cytochrome c of the cell death. During the permeabilization of mitochondrial membrane in apoptosis, the outer mitochondrial membrane becomes so...

EB - Genetika a molekulární biologie

  • 2003 - 2006
    • •
  • 738 tis. Kč
    • •
  • 738 tis. Kč
    • •
  • GA ČR
Project

Deciphering the role of acylated domain in the membrane penetration of Bordetella pertussis adenylate cyclase toxin (GA19-04607S)

translocation of the AC domain across the membrane, as well as the formation of CyaA pores and to define the mechanism of its interaction with cell membrane. A comprehensive array of the whooping cough agent Borde...

Microbiology

  • 2019 - 2021
    • •
  • 9 821 tis. Kč
    • •
  • 9 821 tis. Kč
    • •
  • GA ČR
Project

Controlled Transport of Cell-penetrating Peptides across Biological Membranes – Synergy of Simulations and Single Molecule Fluorescence Experiments (GA25-16117S)

the mechanism of passive translocation of CPPs at the molecular level through advanced in the transport of cargo across membranes, there is another promising method known as direct passive energy-independent translocat...

Biophysics

  • 2025 - 2027
    • •
  • 9 327 tis. Kč
    • •
  • 9 117 tis. Kč
    • •
  • GA ČR
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