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107 (0,199s)

Project

Focused on the liver portal triad understanding the Jagged1 signaling within the periportal mesenchyme (GA25-15821S)

The mesenchymal tissue is a critical compartment of the liver, playing of Notch ligand Jagged1, expressed by the periportal mesenchyme, in hepatoblasts fate effects of disrupted Jagged1 signaling on the mesenchymal tissue a...

Developmental biology

  • 2025 - 2027
  • 9 513 tis. Kč
  • 9 513 tis. Kč
  • GA ČR
Project

Use of mesenchymal stem cells in reconstruction orthopaedics surgery (ND7448)

Mesenchymal stem cells from patients undergoing routine bone marrow examination will be cultived in vitro in media with fetal calf serum and human adult and cord blood serum and differentiated toward osteoblastic lineage. Gene experssion of ...

FJ - Chirurgie včetně transplantologie

  • 2003 - 2005
  • 5 261 tis. Kč
  • 4 899 tis. Kč
  • MZ
Project

Dynamics of cancer cell surface fingerprint plasticity in epithelial-to-mesenchymal transition (GA21-11585S)

The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the homeostasis, evolution of early neoplastic lesions, and cancer dissemination. The ability of tumor cells to adapt to dynamic changes capability, an...

Oncology

  • 2021 - 2023
  • 7 785 tis. Kč
  • 7 785 tis. Kč
  • GA ČR
Project

Autologous mesenchymal stem cells in rotator cuff repair enhancement – preclinical and prospective randomized clinical study (GAP304/10/0326)

and clinical therapeutic application of the autologous mesenchymal stem cells (MSC) alone to the method used to facilitate healing (surgery alone, mesenchymal stem cells, platelet-rich plasma and mesenchymal stem cells com...

FI - Traumatologie a ortopedie

  • 2010 - 2015
  • 4 603 tis. Kč
  • 4 603 tis. Kč
  • GA ČR
Project

The role of MDM2 in epithelial-to-mesenchymal transition implication for cancer progression (GPP301/12/P407)

Most cancer related deaths are associated with advanced disease and metastasis. Epithelial-mesenchymal transition (EMT), in which epithelial cells lose their polarity and become motile mesenchymal cells, is viewed as an essential ea...

FD - Onkologie a hematologie

  • 2012 - 2016
  • 1 963 tis. Kč
  • 1 963 tis. Kč
  • GA ČR
Project

The role of Meis transcription factors in mesenchymal condensations during formation of the cranium (GA22-10660S)

cells or connective tissues. Cranial neural crest-derived mesenchyme condensates mesenchymal condensations. We will use spatial transcriptomics, RNA-seq, in situ......

Developmental biology

  • 2022 - 2024
  • 9 825 tis. Kč
  • 9 825 tis. Kč
  • GA ČR
Project

Spinal cord injury reconstruction using surface-modified biodegradable hydrogels with oriented pores seeded with mesenchymal stem cells (GA14-14961S)

Reconstructing damaged CNS tissue is one of the major issues in neuroscience. Chronic SCI is characterized by a posttraumatic cavity surrounded by a mesenchymal and glial scar, which inhibits CNS regeneration. In this project, fibronectin-su...

FH - Neurologie, neurochirurgie, neurovědy

  • 2014 - 2016
  • 6 300 tis. Kč
  • 6 300 tis. Kč
  • GA ČR
Project

Autologous cell based therapy for ischemic diabetic wounds preclinical and clinical trial (GA14-03540S)

mesenchymal stem cells (BM-MSC) and adipose tissue derived mesenchymal stem cells (AT-MSC...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2014 - 2018
  • 5 444 tis. Kč
  • 5 444 tis. Kč
  • GA ČR
Project

Development of regenerative and advanced therapy medicinal products based on cultured mesenchymal stem cells from umbilical cord (TF03000037)

The goal is to develop an advanced therapy medicinal product based on cultured mesenchymal stem cells (MSCs) derived from umbilical cord tissue and intended for treatment of severe immune-mediated diseases and for regenerative medicine. By t...

EI - Biotechnologie a bionika

  • 2016 - 2019
  • 20 696 tis. Kč
  • 15 244 tis. Kč
  • TA ČR
Project

Human mesenchymal stromal cells for therapeutic purposes. Preclinical and pharmacological testing and approval of the cellular product for clinical use. (NT13531)

Human mesenchymal stromal cells (hMSC) will be prepared form bone blood of patients undergoing bone marrow examination for diagnostic purposes and will be expanded by patented method developed by submitters of the grant project proposal. Pre...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2015
  • 9 234 tis. Kč
  • 9 234 tis. Kč
  • MZ
  • 1 - 10 out of 107