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18 (0,054s) •

Project

Mitochondrial targeting as efficient treatment of pancreatic cancer and type 2 diabetes mellitus (NV16-31604A)

frequent drug against T2DM is the bisguanide compound metformin. This agent is now also anti-cancer and anti-diabetic effects of metformin are dependent on the mitochondrial respiratory complex I. Therefore, we modified metform...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 11 804 tis. Kč
    • •
  • 11 804 tis. Kč
    • •
  • MZ
Project

The role of inflammation in the pathogenesis of diabetes and organ damage possibilities of pharmaceutical interventions (NT14325)

The project is focused on the analysis of the role of inflammatory processes in the pathogenesis of diabetic complications in patients with type 2 diabetes and heart failure. We will specifically study the anti-inflammatory effects of metformin

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2013 - 2015
    • •
  • 5 897 tis. Kč
    • •
  • 5 897 tis. Kč
    • •
  • MZ
Project

Effects of metabolic protection on heart failure in type 2 diabetes (NT14250)

Aim of the project is to test the effect of metformin on myocardial function and load tolerance in a group of patients with T2D and heart failure (HF+DM). In the randomized, placebo controlled, cross-over study, 40 patients with HF+DM will b...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2013 - 2015
    • •
  • 8 948 tis. Kč
    • •
  • 8 948 tis. Kč
    • •
  • MZ
Project

Pharmacological therapy of endocrine and metabolic abnormalities of the polycystic ovary syndrome (PCOS). (NH6558)

The project addresses the possibilities of long-term modulation of endocrine and metabolic abnormalities of the polycystic ovary syndrome (PCOS). The aim of the project is to establish the effect of a hormonal contraceptive containing a low-androgeni...

FK - Gynekologie a porodnictví

  • 2001 - 2003
    • •
  • 1 760 tis. Kč
    • •
  • 1 760 tis. Kč
    • •
  • MZ
Project

Effectiveness of Long-acting or Short-acting Insulin or MEtformin in Dawn Phenomenon in Type 2 diabetic patients (ELSIMED). (NR8093)

Randomized over-cross study on influence of the treatment with short-acting or long-acting insulin or metformin on rise of blood glucose at night (dawn phenomenon-DP), on long-term metabolism and on risk factors in type 2 diabetic patients, ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 1 308 tis. Kč
    • •
  • 1 229 tis. Kč
    • •
  • MZ
Project

Disturbances of glucose tolerance in young girls under long-term glucocorticoid treatment (NE4849)

In the prospective intervention study,the role of specific diabetogennic factors related to insulin resistance condition in a long-term glococorticoid treatment wil be studied at postadolescent female patiens. As wel as possible ways how to influence...

FG - Pediatrie

  • 1998 - 2000
    • •
  • 3 311 tis. Kč
    • •
  • 2 103 tis. Kč
    • •
  • MZ
Project

Premature androgenetic alopecia as a marker of health risks (NR8525)

Androgenetic alopecia could be regarded as a marker of hormonal status and risks resembling those of women with polycystic ovary syndrome. Hormonal levels, insulin resistance and cardiovascular risk factors will be examined and before and after thera...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2005 - 2009
    • •
  • 4 685 tis. Kč
    • •
  • 4 579 tis. Kč
    • •
  • MZ
Project

Effects of omega-3 polyunsaturated fatty acids in type 2 diabetic patients – new mechanisms for targeted therapy (NT13763)

Project will help to understand the mechanisms, by which omega 3 polyunsaturated fatty acids (n3PUFA) normalize lipid metabolism and mitigate low-grade inflammation in patients with type 2 diabetes mellitus (DM), specifically in those treated with

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
    • •
  • 9 983 tis. Kč
    • •
  • 9 923 tis. Kč
    • •
  • MZ
Project

Role of diabetic milieu in selected steps of colon cancer development, its clinical outcomes and response to therapy (GA16-14829S)

and response to metformin not only in diabetes but in general....

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2016 - 2020
    • •
  • 7 133 tis. Kč
    • •
  • 6 584 tis. Kč
    • •
  • GA ČR
Project

Placental NLRP3 inflammasome signaling in gestational diabetes and the therapeutic potential of metformin (NU22J-01-00066)

cytokines IL-1ß and IL-18. Interestingly, metformin, an alternative first-line agent antihyperglycemic effect, metformin has additional therapeutic actions by inhibiting NLRP3......

Reproductive biology (medical aspects to be 3)

  • 2022 - 2025
    • •
  • 6 632 tis. Kč
    • •
  • 6 632 tis. Kč
    • •
  • MZ
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