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Pattern of DNA methylation in retroviral regulatory sequences (GA204/01/0632)
CpG methylation of proviral DNA is the key mechanism of transcriptional regulation of retroviruses by the host cell. We and others have obtained preliminary data that the sequence-specific pattern of methylation, i.e. the methyl...
EB - Genetika a molekulární biologie
- 2001 - 2003 •
- 4 657 tis. Kč •
- 2 210 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2001 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (47%)
Poskytovatel: Grantová agentura České republiky
Promoter methylation analysis of the genes downstream of BRCA1 and BRCA1 - comparison of methylation profiles in mutation carriers and non-carriers (GP301/08/P103)
. These are not extrinsic factors, but genetic and epigenetic changes of DNA. Promoter methylation. Experiments considering methylation are extremely exciting but just sketchy at present hypothesis: There is a specific methylati...
EB - Genetika a molekulární biologie
- 2008 - 2010 •
- 1 563 tis. Kč •
- 1 563 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2008 - 31. 12. 2010
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Application of DNA methylation arrays for assessment of aberrantly methylated genes in MDS and AML patients (OC10042)
, apoptosis, metastasis etc. The alterations of gene promoter methylation lead methylation changes can be used to detect leukemic cells in peripheral blood. We will examine the DNA methylation status of a wide spectrum of g...
FD - Onkologie a hematologie
- 2010 - 2012 •
- 2 400 tis. Kč •
- 2 100 tis. Kč •
- MŠMT
Řešení projektu: 1. 5. 2010 - 30. 11. 2012
Uznané náklady
Podpora ze státního rozpočtu (88%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Mechanisms of DNA methylation and demethylation in higher plants (GA204/99/D001)
Bisulfite genomic sequencing will be applied to study 5S rDNA methylation to reveal principles of DNA methylation in different sequence motives in higher plant genomes. Inheritance of methylation patterns will be studied us...
EB - Genetika a molekulární biologie
- 1999 - 2002 •
- 747 tis. Kč •
- 671 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1999 - 1. 1. 2002
Uznané náklady
Podpora ze státního rozpočtu (90%)
Poskytovatel: Grantová agentura České republiky
Alterations of Methylation Patterns in Tumors of Pediatric Patients. (IZ4348)
DNA methylation influences antioncogene axpression being responsible for malignant tranformation.The correlation between methylation status,antiocogene expression and clinical outcome will be searched for in pediatric oncologic pati...
FD - Onkologie a hematologie
- 1997 - 1999 •
- 2 172 tis. Kč •
- 2 172 tis. Kč •
- MZ
Řešení projektu: 1. 1. 1997 - 1. 1. 1999
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Determination of SNP and DNA methylation profiles in patients with myelodysplatic syndrome by microarrays. (NS9634)
Annotation 1: The aim of the project is determination of SNP and DNA methylation profiles in MDS patients. Annotation 2: We will use Illumina microarrays, "Cancer SNP Panel" for detection of 1421 SNPs located in 408 genes and "Methylatio...
EB - Genetika a molekulární biologie
- 2008 - 2011 •
- 5 986 tis. Kč •
- 5 986 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
New possibilities for application of molecular-diagnostic methods for early detection and proper therapy selection of progressing Non-Small Cell Lung Cancer based on detection and monitoring of hypermethylation of specific genes (NS9718)
progression based on methylation analysis. Testing is directed at methylation of specific bronchoscopy examination. The study will include 150 patients, the methylation changes the therapy. The methylation will be...
FD - Onkologie a hematologie
- 2008 - 2011 •
- 4 744 tis. Kč •
- 4 744 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission (1QS500040508)
We found that heterochromatin antigenic markers as HP1 proteins and methylated observed methylation of H3K9 even in patients without typical BCR/ABL translocation. The exposure of methylated H3K9 in CML granulocytes suggest...
FD - Onkologie a hematologie
- 2005 - 2009 •
- 6 365 tis. Kč •
- 6 365 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2005 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Akademie věd České republiky
Effects of the ectopic DNA methyltransferase expression on the transcription of integrated proviruses (IAA5052804)
into the genomes of rodent embryo fibroblasts and their DNA is densily methylated. In this line, in vitro methylated DNA of RSV LTR-driven reporter constructs upon transfection. The mechanism of methylation suppression is ...
EE - Mikrobiologie, virologie
- 1998 - 2000 •
- 1 725 tis. Kč •
- 1 202 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 1998 - 1. 1. 2000
Uznané náklady
Podpora ze státního rozpočtu (70%)
Poskytovatel: Akademie věd České republiky
DNA methylation in heterogeneous populations of fish spermatozoa after their aging in vitro (GA23-06426S)
understanding of sperm aging in higher vertebrates as well. Sperm DNA methylation patterns methylation as well as the phenotypic and functional changes in populations of fresh/young of the DNA methylation pattern during sp...
Animal and dairy science; (Animal biotechnology to be 4.4)
- 2023 - 2025 •
- 8 312 tis. Kč •
- 8 070 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (97%)
Poskytovatel: Grantová agentura České republiky
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