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22 (0,127s) •

Project

Uncovering the mechanism underlying the tumor-suppressive effects of miR-215 and its substitution as new therapeutic strategy in colorectal cancer (GA16-18257S)

) is miR-215. Our team has previously shown that its expression in tumour tissue is significantly decreased in comparison to adjacent colon tissue and low levels of miR-215 to our preliminary data, substitution of ...

FR - Farmakologie a lékárnická chemie

  • 2016 - 2020
    • •
  • 7 158 tis. Kč
    • •
  • 6 756 tis. Kč
    • •
  • GA ČR
Project

Diagnostic and prognostic relevance of selected microRNAs in myelodysplastic syndromes (NT13847)

Recently, analyses of gene expression identified several miRNAs (miR-34a, miR-224, miR-10a, miR-10b, miR-126, miR-181 family, miRNAs from commonly deleted region, miRNA cluster at 14q32, miR

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 7 438 tis. Kč
    • •
  • 7 438 tis. Kč
    • •
  • MZ
Project

Diagnostic and prognostic role of micro RNA (miR) expression profile in rheumatoid arthritis (NT14498)

Monitoring of circulating miR represents a potential diagnostic and prognostic marker of several cancers. Circulating miR in peripheral blood and synovial fluid is to analyze global expression profile of circulating miR in ...

FP - Ostatní lékařské obory

  • 2013 - 2015
    • •
  • 5 778 tis. Kč
    • •
  • 5 778 tis. Kč
    • •
  • MZ
Project

THE REGULATION OF B CELL RECEPTOR (BCR) SIGNALLING PATHWAY BY MICRORNAS (GJ16-13334Y)

cells. We plan to uncover how specific miRNAs that are induced after DNA damage (miR-34a, miR-1246) act to regulate BCR signalling and identify their target genes and regulatory loops. Our preliminary data suggest that miR...

FD - Onkologie a hematologie

  • 2016 - 2018
    • •
  • 3 293 tis. Kč
    • •
  • 3 293 tis. Kč
    • •
  • GA ČR
Project

Investigation of pathophysiology of human leukemias/lymphomas during manipulation of oncogenic microRNAs. (NS10310)

loop between myelo-lymphoid transcription factor PU.1 and oncogenic microRNA miR-155. Restoration of PU.1 expression corrects the PU.1:miR-155 equilibrium and results in leukemia differentiation. We aim to use miR-155 bloc...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 6 232 tis. Kč
    • •
  • 6 232 tis. Kč
    • •
  • MZ
Project

Two-for-one twisting machine to twist staple yarns. (FA-E3/040)

The research and the development of new double-twisters enabling to twist textile staple yarn of wool, cotton, flax, chemical yarn and their mixtures from the startbobbin with the diameter of 215 mm with the possibility of tangential belt sp...

JQ - Strojní zařízení a nástroje

  • 2000 - 2002
    • •
  • 22 596 tis. Kč
    • •
  • 5 461 tis. Kč
    • •
  • MPO
Project

Research, development and verification of production technology of selected welded joints for pressure vessels of primary circuits of nuclear power plants of type MIR 1200. (TA04021746)

The aim is: 1) research and development of certified welding technology of components for pressure vessels primary circuits of nuclear power plants type MIR 1200, including mapping and subsequent garanty of long-term characteristics of resis...

JF - Jaderná energetika

  • 2014 - 2017
    • •
  • 21 639 tis. Kč
    • •
  • 13 500 tis. Kč
    • •
  • TA ČR
Project

The role of microRNA in cell cycle regulation and differentiation of human embryonic stem cell-derived neural stem cells. (GJ15-18316Y)

differentiation of hESCs into NSCs. Interestingly, deregulation of several of these (eg. miR-21, miR-221, miR-125, etc.) has been associated with cancer. Thus studying......

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 3 986 tis. Kč
    • •
  • 3 986 tis. Kč
    • •
  • GA ČR
Project

Exploiting the Advanced TITUS Facility Passive dumping systém for mechanical vibrations (ME 308)

for numerous material-science experiments on board the space station MIR....

JV - Kosmické technologie

  • 1999 - 2002
    • •
  • 6 600 tis. Kč
    • •
  • 3 400 tis. Kč
    • •
  • MŠMT
Project

Concept of liquid biopsy in mapping of microRNA and oncogenic KRAS mutations for early diagnosis and risk assessment of pancreatic cancer. (NU21-07-00247)

is desired. Deregulated microRNA (miR) expressions hallmark solid tumors, they are stable of miRs may provide important information on the pancreatic disease dynamic. Once droplet PCR, that is very sensitive Relevant (candidate)

Oncology

  • 2021 - 2024
    • •
  • 13 038 tis. Kč
    • •
  • 13 038 tis. Kč
    • •
  • MZ
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