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Projects

93 projects (0,201s) •

Project

Seed-agnostic miRNA binding site classification (GJ19-10976Y)

Argonaute (Ago) proteins use miRNAs as driver sequences to bind specific RNAs-Seq) allow for the transcriptome-wide identification of miRNA binding sites, but cannot identify the responsible miRNAs. Heuristics based on cano...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 750 tis. Kč
    • •
  • 8 750 tis. Kč
    • •
  • GA ČR
Project

miRNA and biochemical pathways in epilpesy (GA16-04726S)

that affect severely patients and their relatives. microRNAs (miRNAs) are short non-coding. Altered miRNA expression profile has been observed in the numerous cases of various of the project miRNA and biochemical pathways ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2020
    • •
  • 9 540 tis. Kč
    • •
  • 8 658 tis. Kč
    • •
  • GA ČR
Project

Tick microRNAs as modulators of vertebrate host physiology (LUABA22020)

Aim 1: Localization and quantification of miRNAs in Ixodes ricinus ticks Aim 2: Cloning of tick miRNA targets and study of the effect of miRNA on mammalian cells Aim 3: Transcriptomic analysis of host gene modulation up...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 1 199 tis. Kč
    • •
  • 1 199 tis. Kč
    • •
  • MŠMT
Project

Endogeneous post-transcriptional regulation of gene function by miRNA (NR9236)

to siRNAs, this project is focused on miRNA analyses that also allow to observe de-repression of gene function using miRNA inhibitors. The project includes: 1) miRNA microarrays; 2) analyses of gene activity changes after ...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 5 693 tis. Kč
    • •
  • 5 626 tis. Kč
    • •
  • MZ
Project

Importance of miRNA deregulation in myelodysplastic syndromes and in other hematological clonal diseases (GP301/09/P579)

. microRNAs (miRNAs), components of the RNA interference mechanism, play key roles in many cell processes incl. hematopoiesis. miRNA deregulation is responsible for cell transformation in a variety of tumors and leukemia; however, <...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 1 546 tis. Kč
    • •
  • 1 546 tis. Kč
    • •
  • GA ČR
Project

The role of microRNA expression in HPV-associated and HPV-independent head and neck tumors (GAP304/12/2244)

MicroRNAs (miRNAs) participate in the regulation of gene expression. miRNA their role in the development of malignant tumors. Levels of expression of some miRNAs are different in tumors and in normal tissues and miRNA

FF - ORL, oftalmologie, stomatologie

  • 2012 - 2017
    • •
  • 7 056 tis. Kč
    • •
  • 7 056 tis. Kč
    • •
  • GA ČR
Project

Integrated microRNA, mRNA expression profiling, linkage and correlation analyses for identification of genes underlying complex traits (GAP301/10/0290)

MicroRNAs (miRNAs) comprise a novel class of endogenous, small, non-coding RNAs as in disease development. In the current project, we will determine miRNA expression in the expression of miRNAs is genetically determined and...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 6 393 tis. Kč
    • •
  • 6 393 tis. Kč
    • •
  • GA ČR
Project

Development of chemical regulators of miRNA and RNAi pathways (GA13-29531S)

Here, we propose to use chemical biology to study miRNA and RNAi pathways. These pathways use small RNAs as sequence-specic guides for silencing gene expression. miRNAs of small molecules inhibiting or stimulating miRNA and...

EB - Genetika a molekulární biologie

  • 2013 - 2018
    • •
  • 8 056 tis. Kč
    • •
  • 8 056 tis. Kč
    • •
  • GA ČR
Project

Diagnostic and prognostic relevance of selected microRNAs in myelodysplastic syndromes (NT13847)

Recently, analyses of gene expression identified several miRNAs (miR-34a, miR-224, miR-10a, miR-10b, miR-126, miR-181 family, miRNAs from commonly deleted region, miRNA cluster at 14q32, miR-29b) whose expression changes in...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 7 438 tis. Kč
    • •
  • 7 438 tis. Kč
    • •
  • MZ
Project

Clinical implication of circulating miRNA in monoclonal gammopathies (NT14575)

Based on analysis of global profiles of expression of serum miRNA, we want to create a new prognostic panel allowing for stratification of patients with monoclonal. The created prognostic panel of miRNA will be identifiable in easil...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 141 tis. Kč
    • •
  • 7 141 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 93